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| 1 | Bremsstrahlung emission from high power laser interactions with constrained targets for industrial radiography显示文摘Laser-solid interactions are highly suited as a potential source of high energy X-rays for nondestructive imaging.A bright,energetic X-ray pulse can be driven from a small source,making it ideal for high resolution X-ray radiography.By limiting the lateral dimensions of the target we are able to confine the region over which X-rays are produced,enabling imaging with enhanced resolution and contrast.Using constrained targets we demonstrate experimentally a(20±3)μm X-ray source,improving the image quality compared to unconstrained foil targets.Modelling demonstrates that a larger sheath field envelope around the perimeter of the constrained targets increases the proportion of electron current that recirculates through the target,driving a brighter source of X-rays. | C.D.Armstrong C.M.Brenner C.Jones D.R.Rusby Z.E.Davidson Y.Zhang J.Wragg S.Richards C.Spindloe P.Oliveira M.Notley R.Clarke S.R.Mirfayzi S.Kar Y.Li T.Scott P.McKenna D.Neely | 2019 | High Power Laser Science and Engineering2019，7，2： | 0 |
| 2 | Skeletal muscle atrophy,regeneration,and dysfunction in heart failure:Impact of exercise training显示文摘This review highlights some established and some more contemporary mechanisms responsible for heart failure(HF)-induced skeletal muscle wasting and weakness.We first describe the effects of HF on the relationship between protein synthesis and degradation rates,which determine muscle mass,the involvement of the satellite cells for continual muscle regeneration,and changes in myofiber calcium homeostasis linked to contractile dysfunction.We then highlight key mechanistic effects of both aerobic and resistance exercise training on skeletal muscle in HF and outline its application as a beneficial treatment.Overall,HF causes multiple impairments related to autophagy,anabolic-catabolic signaling,satellite cell proliferation,and calcium homeostasis,which together promote fiber atrophy,contractile dysfunction,and impaired regeneration.Although both wasting and weakness are partly rescued by aerobic and resistance exercise training in HF,the effects of satellite cell dynamics remain poorly explored. | Harrison Gallagher Paul W.Hendrickse Marcelo G.Pereira T.Scott Bowen | 2023 | Journal of Sport and Health Science2023，12，5： | 0 |
| 3 | Gabapentin prevalence:clinical and forensic experience in St.Louis,Missouri,USA显示文摘Gabapentin(Neurontin)is an anti-epileptic drug that has had wide off-label prescription use since market release due to presumed negligible abuse potential.However,trends in drug misuse have demonstrated that gabapentin misuse is occurring,particularly in those with a history of opioid misuse.This is concerning,because although gabapentin has no direct ligand activity at opioid receptors,it does potentiate the analgesic effect of opioids,and concurrent use of gabapentin and opioids may increase the risk of respiratory depressive effects of opioids.This study investigates the incidence of gabapentin detected in urine samples collected for clinical drug screening purposes in a local hospital emergency department and in postmortem samples submitted by medical examiners in the St.Louis metropolitan area.The prevalence of gabapentin and co-detected drugs in both populations is contrasted,compared,and discussed.This study found that 30%of urine samples collected from patients with suspected drug intoxication presenting to SSM Health Saint Louis University Hospital,a quaternary care medical center,were positive for gabapentin,and nearly two thirds of those were also positive for oxycodone.Over a 6-month period,the incidence of gabapentin positive postmortem cases increased from 18%to 20%.Nearly all gabapentin positive postmortem cases were also positive for an opioid,the most significant being fentanyl,suggesting that gabapentin misuse may be due to its potentiating effect of opioid drug action.This study also highlights the limited utility of immunoassay-based urine drug screens. | Sarah B.Riley Kelsie Garbutt Chelsea Crow T.Scott Isbell Anthony J.Scalzo | 2021 | Forensic Sciences Research2021，6，4： | 0 |
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