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| 1 | 阿司匹林用于结直肠癌预防(英文)显示文摘一直以来,实验室研究、流行病学调查和最近的随机对照临床试验都表明阿司匹林可以降低结直肠癌的风险。出于对潜在的副作用如胃肠道出血的考虑,此前美国预防医学工作组的专家曾经建议对于处于平均风险的普通人群不要常规使用阿司匹林来预防结直肠癌。然而,最近的高质量证据表明,阿司匹林不仅可以预防结直肠癌,对其它癌症也有预防作用。因此,值得重新考虑阿司匹林是否可常规用于癌症预防这个问题。本文总结了这些支持阿司匹林化学预防功效的有力证据,认为阿司匹林广泛的抗癌效应加上它在预防心血管疾病中的作用可能推动阿司匹林在众多患者中的长期应用。 | Andrew T.Chan | 2013 | 化学进展2013，25，9： | 3 |
| 2 | Systemic treatment for inoperable pancreatic adenocarcinoma: review and update显示文摘There have been many clinical trials conducted to evaluate novel systemic regimens for unresectable pancreatic cancer. However, most of the trial results were negative, and gemcitabine monotherapy has remained the standard systemic treatment for years. A number of molecular targeted agents, including those against epidermal growth factor receptor and vascular endothelial growth factor receptors, have also been tested. In recent years, there have been some breakthroughs in the deadlock: three regimens, namely gemcitabine-erlotinib, FOLFIRINOX, and gemcitabine-nab-paclitaxel, have been shown to prolong the overall survival of patients when compared with gemcitabine monotherapy. In addition, emerging data suggested that the membrane protein human equilibrative nucleotide transporter 1 is a potential biomarker with which to predict the efficacy of gemcitabine. Here we review the literature on the development of systemic agents for pancreatic cancer, discuss the current choices of treatment, and provide future directions on the development of novel agents. | Stephen L.Chan Sin T.Chan Eric H.Chan Zhe-Xi He | 2014 | Chinese Journal of Cancer2014，33，6： | 2 |
| 3 | Reported behavior of eating anything at anytime and risk of colorectal cancer in women显示文摘 | YingBao KatharinaNimptsch Andrew T.Chan KimmieNg Jeffrey A.Meyerhardt Walter C.Willett EdwardGiovannucci Charles S.Fuchs | 2012 | Int J Cancer2012，，6： | 1 |
| 4 | A multiphase level set framework for image seg-mentation using the Mumford and Shah model显示文摘 | L.Vese T.Chan | | 0，，： | 1 |
| 5 | Solution of the 2D shallow water equations using the finite volume method on unstructured triangular meshes显示文摘 | K.Anastasiou C. T.Chan | 1999 | Int J Numer Meth Fluids1999，，11： | 1 |
| 6 | Identification of acoustic emission wave modes for accurate source location in plate‐like structures显示文摘 | ManindraKaphle Andy C. C.Tan David P.Thambiratnam Tommy H. T.Chan | 2012 | Struct Control Health Monit2012，，2： | 1 |
| 7 | Ribosomal proteins and human diseases:molecular mechanisms and targeted therapy显示文摘Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation.The ribosomal proteins(RPs),comprising the structural parts of the ribosome,are essential for ribosome assembly and function.In addition to their canonical ribosomal functions,multiple RPs have extra-ribosomal functions including activation of p53-dependent or p53-independent pathways in response to stress,resulting in cell cycle arrest and apoptosis.Defects in ribosome biogenesis,translation,and the functions of individual RPs,including mutations in RPs have been linked to a diverse range of human congenital disorders termed ribosomopathies.Ribosomopathies are characterized by tissue-specific phenotypic abnormalities and higher cancer risk later in life.Recent discoveries of somatic mutations in RPs in multiple tumor types reinforce the connections between ribosomal defects and cancer.In this article,we review the most recent advances in understanding the molecular consequences of RP mutations and ribosomal defects in ribosomopathies and cancer.We particularly discuss the molecular basis of the transition from hypo-to hyper-proliferation in ribosomopathies with elevated cancer risk,a paradox termed'Dameshek's riddle.'Furthermore,we review the current treatments for ribosomopathies and prospective therapies targeting ribosomal defects.We also highlight recent advances in ribosome stress-based cancer therapeutics.Importantly,insights into the mechanisms of resistance to therapies targeting ribosome biogenesis bring new perspectives into the molecular basis of cancer susceptibility in ribosomopathies and new clinical implications for cancer therapy. | Jian Kang Natalie Brajanovski Keefe T.Chan Jiachen Xuan Richard B.Pearson Elaine Sanij | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 8 | Assessment of COVID-19 aerosol transmission in a university campus food environment using a numerical method显示文摘With the prevalence of COVID-19,the phenomenon of viruses spreading through aerosols has become a focus of attention.Diners in university dining halls have a high risk of exposure to respiratory droplets from others without the protection of face masks,which greatly increases the risk of COVID-19 transmission.Therefore,the transmission mechanism of respiratory droplets in extremely crowded dining environments should be investigated.In this study,a numerical simulation of coughing at dining tables under two conditions was performed,namely the presence and absence of protective partitions,and the evaporation and condensation of aerosol droplets in the air were examined.By using the numerical method,we analyzed and verified the isolation effect of dining table partitions in the propagation of aerosol droplets.The effect of changes in room temperature on the diffusion of coughed aerosols when partitions were present was analyzed.We demonstrated how respiratory droplets spread through coughing and how these droplets affect others.Finally,we proposed a design for a dining table partition that minimizes the transmission of COVID-19. | M.Zhao C.Zhou T.Chan C.Tu Y.Liu M.Yu | 2022 | Geoscience Frontiers2022，13，6： | 1 |
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