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| 1 | 高产奶量的母猪有更高的采食量和体动员显示文摘选择能哺育更大窝产仔数的超高产母猪以提高产仔数,但是综合考虑这些现代母猪产奶量、采食量和体动员相互之间联系的研究还很有限。试验旨在研究什么样的母猪产奶量高、窝产仔数多,不同胎次有何影响,以及哺乳期生产性能对下一胎繁殖性能有何影响。选择565头1~4胎母猪,试验期从产前7 d至断奶。产后第2天每窝仔猪统一调整为14头。产前7 d、产后第2天和断奶时测定母猪体重和背膘厚度。产后第2天和断奶时称取仔猪窝重。计算变量之间的皮尔森相关系数,建立回归模型。母猪的平均日采食量(6.1±1.1)kg,仔猪每天窝增重(2.92±0.53)kg,每头母猪的平均断奶仔猪数(13.0±1.1)头。总的来讲,与2~4胎母猪相比,1胎母猪平均日采食量和产奶量更低,下一胎总产仔数也下降,这可能是因为初产母猪相比经产母猪会动用更多体储。仔猪每窝平均日增重与母猪的采食量、窝产仔数和体重损失呈正相关。1~4胎母猪整个哺乳期日采食量每提高1 kg,仔猪窝日增重提高220~440 g,母猪哺乳期体重下降6.6~13.9 kg。但是每天平均产奶量提高1 kg,第4胎母猪哺乳期体重损失减少4.3~21.0 kg。下一胎总产仔数与上一胎产仔数呈正相关。总之,高采食量和高体动员是高产奶量的先决条件。母猪可能已经非常接近他们身体饲料摄取的生理极限,因此,未来的研究应着眼于优化哺乳期超高产母猪的饲粮能量和营养浓度以及初产母猪和经产母猪之间的区别。 | Strathe A V Bruun T S Hansen C F 李元凤 | 2017 | 养猪2017，，4： | 8 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 4 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 5 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 6 | Immunoreactivity of CD45,a protein phosphotyrosine phosphatase,in Alzheimer' s disease 显示文摘 | Masliah E Mallory M Hansen L Alford M Albright T Terry R | 1991 | Acta Neuropathol( Berl )1991，83，1： | 2 |
| 7 | Thalassiolins A-C: new marine-derived inhibitors of HIV eDNA integrase显示文摘 | Rowley D C Hansen M S T Rhodes D | 2002 | Bioorg Med Chen2002，10，： | 1 |
| 8 | Do g-teen areas affect health? Results froma Danish survey on the use of green areas and health indicators显示文摘 | Nielsen T S Hansen K B | 2007 | Health Place2007，13，： | 1 |
| 9 | Cerebral autoregulation in patients with end-stage liver disease显示文摘 | Strauss GI Hansen BA Herzog T | 2000 | Eur J Gastroenterol Hepatol2000，12，7： | 1 |
| 10 | Bilirubin has wide spread inhib- itory effects on protein phosphorylation 显示文摘 | HANSEN T W MATHIESEN S B WALAAS S T | 1996 | Pediatr Res1996，39，6： | 1 |
| 11 | Cyclic AMP induced neuronal differentiation via activation of p38 mitogen-activated protein kinase显示文摘 | Hansen T O Rehfeld J F Nielsen F C | 2000 | J Neurochem2000，75，5： | 1 |
| 12 | Method for determination of methane potentials of solid organic waste显示文摘 | Hansen T L Schmidt J E Angelidaki l | 2004 | Waste Management2004，24，： | 1 |
| 13 | Different knowledge, different benefits: Toward a productivity perspective on knowle- dge sharing in organizations显示文摘 | Haas M R Hansen M T | 2007 | Strategic Management Journal2007，28，11： | 1 |
| 14 | Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development显示文摘 | Hansen L A Alexander N Hogan M E Sundberg J P Dlugosz A Threadgill D W Magnuson T Yuspa S H | | 0，，06： | 1 |
| 15 | Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethyl- hexyl) phthalate and ovalbumin in BALB/e mice 显示文摘 | Larsen S T Hansen J S Hansen E K | 2007 | Toxicology2007，235，： | 1 |
| 16 | The search - transfer problem : The role of weak ties in sharing knowledge across organization subunits 显示文摘 | HANSEN M T | 1999 | Administra- tive Science Quarterly1999，44，1： | 1 |
| 17 | The search - transfer problem: The role ofweak ties in sharing knowledge across organization subunits显示文摘 | Hansen Morten T | 1999 | Administrative Science Quarterly1999，44，1： | 1 |
| 18 | Prognostic value of short-term blood pressure variability over 24 h in 8938 subjects 'rom 11 pop- ulation显示文摘 | Hansen T Thijs L Yan L eta | 2009 | Int J Cardiol2009，113，7： | 1 |
| 19 | Homoeysteine and the produetien of collagens proliferation and apoptosis in human arterial smooth muscle cells显示文摘 | Rasmussen LM Hansen PR Ledet T | 2004 | APMIS2004，112，9： | 1 |
| 20 | Fractal pore space and rock permeability implications显示文摘 | Hansen J P Skjeltorp A T | 1988 | Physical Review B1988，38，4： | 1 |
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