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| 1 | Nitrogen(N) metabolism related enzyme activities,cell uitrastructure and nutrient contents as affected by N level and barley genotype显示文摘Development of the new crop cultivars with high yield under low nitrogen(N) input is a fundamental approach to enhance agricultural sustainability,which is dependent on the exploitation of the elite germplasm.In the present study,four barley genotypes(two Tibetan wild and two cultivated),differing in N use efficiency(NUE),were characterized for their physiological and biochemical responses to different N levels.Higher N levels significantly increased the contents of other essential nutrients(P,K,Ca,Fe,Cu and Mn),and the increase was more obvious for the N-efficient genotypes(ZD9 and XZ149).The observation of ultrastructure showed that chloroplast structure was severely damaged under low nitrogen,and the two high N efficient genotypes were relatively less affected.The activities of the five N metabolism related enzymes,i.e.,nitrate reductase(NR),glutamine synthetase(GS),nitrite reductase(NiR),glutamate synthase(GOGAT) and glutamate dehydrogenase(GDH) all showed the substantial increase with the increased N level in the culture medium.However the increased extent differed among the four genotypes,with the two N efficient genotypes showing more increase in comparison with the other two genotypes with relative N inefficiency(HXRL and XZ56).The current findings showed that a huge difference exists in low N tolerance among barley genotypes,and improvement of some physiological traits(such as enzymes) could be helpful for increasing N utilization efficiency. | Jawad Munawar Shah Syed Asad Hussain Bukhari ZENG Jian-bin QUAN Xiao-yan Essa Ali Noor Muhammad ZHANG Guo-ping | 2017 | Journal of Integrative Agriculture2017，16，1： | 4 |
| 2 | Synergistic effects of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation显示文摘Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also evaluated.Results: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined therapy.The time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined therapy.Conclusion: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis. | Syed Nasir Abbas Bukhari Fahad Hussain Hnin Ei Thu Zahid Hussain | 2019 | Journal of Integrative Medicine2019，17，1： | 4 |
| 3 | Bioassay-guided isolation of novel and selective urease inhibitors from Diospyros lotus显示文摘Two new dimeric naphthoquinones, 5′,8′-dihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(1; Di-naphthodiospyrol D) and 5′,8′-dihydroxy-5,8-dimethoxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(2; Di-naphthodiospyrol E), along with known naphthoquinones diospyrin(3) and 8-hydroxy diospyrin(4) were isolated from the chloroform fraction of extract of Diospyros lotus roots. Their structures were elucidated by advanced spectroscopic analyses, including HSQC, HMBC, NOESY, and J-resolved NMR experiments. The fractions and compounds 1-4 were evaluated for urease activity and phosphodiesterase-Ⅰ, carbonic anhydrase-Ⅱ and α-chymotrypsin enzyme inhibitory activities. Compounds 1 and 2 and their corresponding fractions showed significant and selective inhibitory effects on urease activities. The IC_(50) values of 1 and 2 were 260.4 ± 6.37 and 381.4 ± 4.80 μmol·L-1, respectively, using thiourea(IC_(50) = 21 ± 0.11 μmol·L^(-1)) as the standard inhibitor. This was the first report demonstrating that the naphthoquinones class showed urease inhibition. | Abdur Rauf Ghias Uddin Bina S. Siddiqui Ajmal Khan Umar Farooq Farhan A. Khan Syed Majid Bukhari Sher Bahadar Khan | 2017 | Chinese Journal of Natural Medicines2017，15，11： | 2 |
| 4 | Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis显示文摘Two new sesquiterpenes, trivially named ricinusoids A(1) and ricinusoids B(2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1 D-and 2 D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds(1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg^(–1) i.p. Pretreatment of both test compounds caused significant(P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds(1-2) possessed marked sedative and antinociceptive effects in animal models. | Umar Farooq Ajmal Khan Sadia Naz Abdur Rauf Haroon Khan Afsar Khan Irfan Ullah Syed Majid Bukhari | 2018 | Chinese Journal of Natural Medicines2018，16，3： | 2 |
| 5 | Intelligent Islanding Detection of Multi-distributed Generation Using Artificial Neural Network Based on Intrinsic Mode Function Feature显示文摘The integration of distributed energy resources(DERs) into distribution networks is becoming increasingly important, as it supports the continued adoption of renewable power generation, combined heat and power plants, and storage systems. Nevertheless, inadvertent islanding operation is one of the major protection issues in distribution networks connected to DERs. This study proposes an intelligent islanding detection method(IIDM) using an intrinsic mode function(IMF)feature-based grey wolf optimized artificial neural network(GWO-ANN). In the proposed IIDM, the modal voltage signal is pre-processed by variational mode decomposition followed by Hilbert transform on each IMF to derive highly involved features. Then, the energy and standard deviation of IMFs are employed to train/test the GWO-ANN model for identifying the islanding operations from other non-islanding events. To evaluate the performance of the proposed IIDM, various islanding and non-islanding conditions such as faults, voltage sag, linear and nonlinear load and switching, are considered as the training and testing datasets. Moreover, the proposed IIDM is evaluated under noise conditions for the measured voltage signal. The simulation results demonstrate that the proposed IIDM is capable of differentiating between islanding and non-islanding events without any sensitivity under noise conditions in the test signal. | Samuel Admasie Syed Basit Ali Bukhari Teke Gush Raza Haider Chul Hwan Kim | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 2 |
| 6 | Conversion of coal fly ash to zeolite utilizing microwave and ultrasound energies : A review显示文摘 | Syed Salman Bukhari Jamshid Behin | | Fuel t20\50，140，1： | 1 |
| 7 | Cardiogenic shock in the setting of acute myocardial infarction:Another area of sex disparity?显示文摘Cardiogenic shock in the setting of acute myocardial infarction(AMI)carries significant morbidity and mortality,despite advances in pharmacological,mechanical and reperfusion therapies.Studies suggest that there is evidence of sex disparities in the risk profile,management,and outcomes of cardiogenic shock complicating AMI.Compared with men,women tend to have more comorbidities,greater variability in symptom presentation and are less likely to receive timely revascularization and mechanical circulatory support.These factors might explain why women tend to have worse outcomes.In this review,we highlight sex-based differences in the prevalence,management,and outcomes of cardiogenic shock due to AMI,and discuss potential ways to mitigate them. | Syed Bukhari Shumail Fatima Islam Y Elgendy | 2021 | World Journal of Cardiology2021，13，6： | 1 |
| 8 | Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity显示文摘Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C(Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses(UV, IR, Mass, ~1 H-and ^(13)C-NMR, and two-dimensional(2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·m L^(-1) against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae. | Umar Farooq Sara Khan Sadia Naz Ajmal Khan Afsar Khan Ayaz Ahmed Abdur Rauf Syed Majid Bukhari Shujaat Ali Khan Arfa Kamil Nadia Riaz Abdur Rahman Khan | 2017 | Chinese Journal of Natural Medicines2017，15，12： | 0 |
| 9 | Assessment of Phosphorus Levels in Small Ruminants as Affected by Summer and Winter显示文摘An experiment was carried out to assess the phosphorus status of free grazing goats at Faisalabad,Pakistan.Samples were collected fortnightly during summer and winter seasons of 2010 from soil and plants.The highest(118±0.54 mg·kg-1)levels of feces phosphorus were recorded in lactating goats during winter and(9.87±0.99 mg·kg-1)in urine of male during winter.Similarly maximum(71.0±0.88 mg·kg-1)phosphorus concentration was observed in the plasma of lactating animals.Milk contained(31.0±0.36)mg·L-1 in winter while during the months of summer the highest values recorded in forages,soils,canal and tube well waters were(755±1.98)mg·kg-1,(785±4.98)mg·kg-1,(0.97±8.78)mg·L-1 and(4.12±0.55)mg·L-1,respectively.It was revealed from the current results that fecal matter,forage,milk,tube well and canal water contained lower amounts of P,while P levels in blood plasma was found within the critical limits.Therefore,phosphorus supplementations were required in the area under experimentation to meet the requirements of the animals for their normal growth. | Ansar Mahmood Dr.Asma Hassan Iram Maqsood Tang Li-jie Syed Mohsin Bukhari Khalil-Ur-Rehman and Shahla Andleeb | 2014 | Journal of Northeast Agricultural University(English Edition)2014，21，1： | 0 |
| 10 | A Blockchain Based Framework for Stomach Abnormalities Recognition显示文摘Wireless Capsule Endoscopy(WCE)is an imaging technology,widely used in medical imaging for stomach infection recognition.However,a one patient procedure takes almost seven to eight minutes and approximately 57,000 frames are captured.The privacy of patients is very important and manual inspection is time consuming and costly.Therefore,an automated system for recognition of stomach infections from WCE frames is always needed.An existing block chain-based approach is employed in a convolutional neural network model to secure the network for accurate recognition of stomach infections such as ulcer and bleeding.Initially,images are normalized in fixed dimension and passed in pre-trained deep models.These architectures are modified at each layer,to make them safer and more secure.Each layer contains an extra block,which stores certain information to avoid possible tempering,modification attacks and layer deletions.Information is stored in multiple blocks,i.e.,block attached to each layer,a ledger block attached with the network,and a cloud ledger block stored in the cloud storage.After that,features are extracted and fused using a Mode value-based approach and optimized using a Genetic Algorithm along with an entropy function.The Softmax classifier is applied at the end for final classification.Experiments are performed on a private collected dataset and achieve an accuracy of 96.8%.The statistical analysis and individual model comparison show the proposed method’s authenticity. | Muhammad Attique Khan Inzamam Mashood Nasir Muhammad Sharif Majed Alhaisoni Seifedine Kadry Syed Ahmad Chan Bukhari Yunyoung Nam | 2021 | Computers, Materials & Continua2021，，4： | 0 |
| 11 | Morphological Variations,Distribution and Population Estimation of Indian Spiny Tailed Liza rd(Uromastyx hardwickii Gray,1827)from District Bahawalnagar,Punjab,Pakistan显示文摘This study was conducted in selected sites of District Bahawalnagar namely,Shaheed Chowk,Chak40/F,Chak 163/7 R and Fareedkot Tiba between March 2019 and August 2019.Sampling techniques included recording of burrows,flooding,burrow exaction,noose traps and pit fall traps were used to capture Uromast yx hardwickii.During this survey150 individuals were captured from study area for morphological measurement and population estimation.The average snout to vent length(SVL)of male,female and juveniles were(172.50±19.71)mm,(155.50±18.72)mm and(86.25±11.72)mm respectively.The average weight of male,female and juvenile was(93.06±8.56)g,(88.16±7.95)g and(40.16±4.30)g respectively.The relative abundance(Pi)of males,females and juveniles were 0.53,0.33 and 0.13.Indian spiny tailed lizard(U.hardwickii)has been listed in the IUCN Red list and CITES.Major threats to the species in the study area are increase in urbanization,habitat fragmentation,illegal hunting for meat and fat.In this regard strict implementation of the Wildlife act is needed to protect the wildlife of Punjab.Furthermore,comprehensive surveys are required in throughout Punjab to declare conservation status of U.hardwickii. | Waqas ALI Arshad JAVID Saddam HUSSAIN Ali HUSSAIN Syed Mohsin BUKHARI | 2020 | Asian Herpetological Research2020，11，3： | 0 |
| 12 | Cardiac amyloidosis: state-of-the-art review显示文摘Cardiac amyloidosis(CA)is caused by deposition of amyloid fibrils in the myocardium and has two main sub-types,transthyretin cardiac amyloidosis(ATTR)and immunoglobulin light chain cardiac amyloidosis(AL).ATTR is further dif-ferentiated into wild-type(wtATTR)and hereditary(hATTR),depending on the absence or presence of mutation in the trans-thyretin gene.The increased recognition of disease with the improvement in diagnostic armamentarium and serendipitous ad-vancements in the therapeutic landscape have changed the status of CA from being a rare and untreatable disease to being a not-so-rare and treatable disease.Both ATTR and AL have certain clinical aspects that can provide early clues for the disease.While electrocardiography followed by echocardiography and subsequently cardiac magnetic resonance can raise suspicion for CA,the definitive diagnosis of ATTR is non-invasively established by bone scintigraphy while that of AL always needs histological con-firmation.Severity of CA can be gauged by serum biomarker-based staging of both ATTR and AL.ATTR therapies work by silen-cing or stabilizing TTR or by degrading amyloid fibrils,while AL is managed with anti-plasma cell therapies and autologous stem cell transplant. | Syed Bukhari | 2023 | Journal of Geriatric Cardiology2023，20，5： | 0 |
| 13 | Magnetoelectric effect in multiferroic NdMn2O5显示文摘We have measured the dielectric constant for NdMn_2O_5 in an external magnetic field to map out the magnetoelectric phase diagram. The phase diagram corresponds well with the previously reported data of neutron diffraction and magnetic susceptibility. Our main finding is the observation of a dielectric anomaly in the low temperature phase with a strong magnetoelectric effect, which is attributed to the independent Nd^(3+) ordering. Moreover, the absence of the dielectric anomaly in the paramagnetic phase is discussed, keeping in view the exchange interaction and its dependence on the rareearth R^(3+) ionic radius. | Syed Hamad Bukhari Javed Ahmad | 2017 | Chinese Physics B2017，26，1： | 0 |
| 14 | Classification of Positive COVID-19 CT Scans Using Deep Learning显示文摘In medical imaging,computer vision researchers are faced with a variety of features for verifying the authenticity of classifiers for an accurate diagnosis.In response to the coronavirus 2019(COVID-19)pandemic,new testing procedures,medical treatments,and vaccines are being developed rapidly.One potential diagnostic tool is a reverse-transcription polymerase chain reaction(RT-PCR).RT-PCR,typically a time-consuming process,was less sensitive to COVID-19 recognition in the disease’s early stages.Here we introduce an optimized deep learning(DL)scheme to distinguish COVID-19-infected patients from normal patients according to computed tomography(CT)scans.In the proposed method,contrast enhancement is used to improve the quality of the original images.A pretrained DenseNet-201 DL model is then trained using transfer learning.Two fully connected layers and an average pool are used for feature extraction.The extracted deep features are then optimized with a Firefly algorithm to select the most optimal learning features.Fusing the selected features is important to improving the accuracy of the approach;however,it directly affects the computational cost of the technique.In the proposed method,a new parallel high index technique is used to fuse two optimal vectors;the outcome is then passed on to an extreme learning machine for final classification.Experiments were conducted on a collected database of patients using a 70:30 training:Testing ratio.Our results indicated an average classification accuracy of 94.76%with the proposed approach.A comparison of the outcomes to several other DL models demonstrated the effectiveness of our DL method for classifying COVID-19 based on CT scans. | Muhammad Attique Khan Nazar Hussain Abdul Majid Majed Alhaisoni Syed Ahmad Chan Bukhari Seifedine Kadry Yunyoung Nam Yu-Dong Zhang | 2021 | Computers, Materials & Continua2021，，3： | 0 |
| 15 | The microRNA pathway controls germ cell proliferation and differentiation in C. elegans显示文摘miRNA 小径的发现揭示了生物过程的分子的控制的新层。揭开这基因的新功能规章的小径,我们在 Caenorhabditis elegans, ALG-1 和 ALG-2 拿了二 miRNA 特定的 Argonaute 蛋白质的描述。我们首先观察到 alg-1 和 alg-2 基因的 loss-of-function 导致了减少的子孙数字。这些异种的 germline 的广泛的分析揭示了一个减少的有丝分裂的区域,显示更少增殖的细菌房间。我们也在 alg-1 和 alg-2 异种动物观察了一个早条目进成熟分裂。我们在远侧的尖端房间(DTC ) 检测了 ALG-1 和 ALG-2 蛋白质表情,在两 C 的尖端定位的一个专业化房间。调整有丝分裂成熟分裂转变的 elegans gonadal 手臂。在变异的动物的 DTC 明确地重建 alg-1 的表示部分救了观察 germline 缺点。进一步的分析也在 gametogenesis 支持 miRNA 小径的含意。有趣地,我们观察到在 DTC 表示的五 miRNAs 的那混乱导致了类似的显型。最后, alg-1 异种性腺的基因表示分析建议 miRNA 小径涉及为 germline 增长和区别重要的不同小径的规定。一起,我们的数据显示 miRNA 小径在 C 在细菌房间生物的续生说的控制起一个关键作用。elegans。 | Syed Irfan Ahmad Bukhari Alejandro Vasquez-Rifo Dominic Gagne' Eric R Paquet Monique Zetka Claude Robert Jean-Yves Masson Martin J Simard | 2012 | Cell Research2012，22，6： | 0 |
| 16 | 基于深度卷积神经网络的两阶段肺结节检测显示文摘针对传统肺结节检测中存在灵敏度低、假阳性高、小结节难检测的问题,提出一种基于深度卷积神经网络的两阶段肺结节检测框架。第一阶段使用特征金字塔子网提取肺部影像的多层次特征,引入多尺度区域建议子网用于在高灵敏度下检测出所有的候选结节;第二阶段设计级联卷积神经网络模型减少假阳性,通过保留分类错误样本用于重新训练模型,将多个模型结果进行投票选出最终分类结果。LUNA16数据集上的实验结果表明,所提框架灵敏度达到95.9%,检测效果优于其它算法,能够有效实现肺结节的准确检测。 | 韩鹏 强彦 刘继华 贾婧 Syed Basit Ali Shah Bukhari | 2021 | 计算机工程与设计2021，42，3： | 0 |
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