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| 1 | Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves(field grown & in vitro raised) extracts on alloxan induced diabetic rats显示文摘Objective:To investigate antidiabetic efficacy of the extract of field grown and in vitro raised leaves of Solanum xanthocarpum(S.xanthocarpum) against alloxan induced diabetic rats. Methods:The antidiabetic activity of the crude methanol extracts of the field grown and in vitro raised leaves of S.xanthocarpum at different concentrations(100-200 mg/kg bw) was tested against alloxan induced diabetic rats.The antidiabetic efficacy was validated through various biochemical parameters and the antioxidant effect was also determined.The phytochemical analyses of field grown S.xanthocarpum and in vitro rasied 5.xanthocarpum leaves were done by estimating their chlorophyll,carotenoids,total sugar,protein,amino acid and minerals contents. Results:The results revealed that the methanol extracts of both the leaves(field grown and in vitro raised) of S.xanthocarpum was efficient anti hyperglycemic agents at a concentration of 200 mg/kg bw and posses potent antioxidant activity.However,the extracts of in vitro rasied S.xanthocarpum raised leaves exhibit higher efficacy than the field grown leaves in all tested concentrations.Proximal composition and mineral analysis of S.xanthocarpum revealed higher concentration of contents in in vitro rasied S.xanthocarpum than field grown S.xanthocarpum. Conclusions:From the results it can be concluded that the leaves extracts of S.xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress. | K Poongothai P Ponmurugan K Syed Zameer Ahmed B Senthil Kumar SA Sheriff | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 9 |
| 2 | Microstructure and Mechanical Property of in-situ Al-Cu/TiC Composites显示文摘An approach named direct reaction synthesis (DRS) has been developed to fabricate particulate composites with an extremely fine reinforcement size. ID situ Al matrix composites were fabri-cated by DRS. Extensive analysis of the composites microstructure using SEM and TEM identify that the reinforcement formed during the DRS process is Ti carbide (TiC) particle, generally less than 1.0 μm. The reacted, semisolid extruded samples exhibit a homogeneous distribution of fine TiC particles in Al-Cu matrix, Mechanical property evaluation of the composites has revealed a very high tensile strength relative to the matrix alloy. Fractographic analysis indicates ductile failure although the ductility and strength are limited by the presence of coarse titanium aluminides (Al3Ti). | Zhang, EL Zeng, SY Yang, B Li, QC Ma, MZ | 1998 | Journal of Materials Science & Technology1998，14，3： | 6 |
| 3 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 4 | 男性C反应蛋白、纤维蛋白原和心肺适应性与高血压发生风险的相关性显示文摘在正常血压和高血压高危人群中,较高的心肺适应性(cardiorespiratory fitness)可预防高血压[1-2]。但高心肺适应性能否降低炎症水平升高的受试者发生高血压的风险,尚不清楚。本研究旨在探讨男性中,独立于肥胖,炎症与高血压发生的相关性;心肺适应性、炎症与高血压发生的联合相关性。研究者假设炎症与高血压发生相关,但高心肺适应性可降低这种相关性。 | Jae SY Kurl S Laukkanen JA Lee CD Choi YH Fernhall B Franklin BA | 2015 | 中华高血压杂志2015，23，9： | 2 |
| 5 | A regulatory role for TRAF1 in antigen-induced apoptosis of T cells 显示文摘 | Speiser DE Lee SY Wong B | 1997 | J Exp Med1997，185，10： | 2 |
| 6 | Cold induces reactive oxygen species production and activation of the NF - kappa B re- sponse in endothelial cells and inflammation in vivo显示文摘 | Awad EM Khan SY Sokolikova B | 2013 | J Thromb Haemost2013，11，9： | 1 |
| 7 | Apoptosis and caspase-2 in long-term renal ischemia/reperfusion injury in rats and divergent effects of immunosuppressants显示文摘 | Yang B Jain S Ashra SY | 2006 | Transplantation2006，81，10： | 1 |
| 8 | Design and analysis of a propagation delay tolerant aloha protocol for underwater networks 显示文摘 | AHN J SYED A KRISHNAMACHARI B et aI | 2010 | AD HQC Networks2010，7，9： | 1 |
| 9 | Corneal thickness and intraocular pressure in the Barbados eye studies显示文摘 | Nemesure B Wu SY Hennis A | 2003 | Arch Ophthalmol2003，121，： | 1 |
| 10 | Evaluation of 4-ami-nobiphenyl DNA adducts in human breast cancer : the influenceof tobacco smoke显示文摘 | Faraglia B Chen SY Gammon MD | 2003 | Carcinogenesis2003，24，4： | 1 |
| 11 | Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat显示文摘 | Cho B Choi SY Park OH | 2012 | Mol Cells2012，33，6： | 1 |
| 12 | Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab\')2:a possible implication for mucosal defense显示文摘 | Crottet P Corthésy B | 1998 | The Journal of Immunology1998，161，10： | 1 |
| 13 | Propranolol for complicated infantile haemangiornas:a case series of 30 infants显示文摘 | Manunza F Syed S Laguda B | | 0，，02： | 1 |
| 14 | Influence of equilibrium shear flow along the magnetic flows on the resistive tearing instability显示文摘 | PARIS R B SY W N-C | 1983 | Physics of Fluids1983，26，： | 1 |
| 15 | Development and application of a mechanistic model to estimate emission of nitrous oxide from UK agriculture显示文摘 | Brown L Syed B Jarvis S C | 2002 | Atmospheric Environment2002，36，6： | 1 |
| 16 | Experimental Study on Oxygen-enriched Combustion of Biomass Microfuel显示文摘 | Luo SY Xiao B Hu ZQ Liu SM Guan YW | 2009 | Energy2009，34，11： | 1 |
| 17 | Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder显示文摘 | You JS Hu SY Chen B | 2005 | Psychiatr Genet2005，15，1： | 1 |
| 18 | Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, dc-biased, ac electric fields显示文摘 | HAWK/NS B ~ SMITH A E SYED Y A | 2007 | Analytical Chemistry2007，79，19： | 1 |
| 19 | Role of QuantiFERON-TB gold,interferon gamma inducible protein-10and tuberculin skin test in active tuberculosis diagnosis显示文摘 | Syed Ahamed Kabeer B Raman B Thomas A | 2010 | PLoS One2010，5，2： | 1 |
| 20 | Flow and heat transfer correlations for porous fin in a plate-fin heat exchanger显示文摘 | Kim SY PAEK J W KANG B H | 2000 | J of Heat Transfer2000，122，： | 1 |
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