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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Generalized set-valued variational inclusions in Banach spaces 显示文摘 | Chang S S Cho Y J Lee B S | 2000 | J Math Anal Appl2000，246，： | 2 |
| 3 | Sensitivity Analysis for Strongly Nonlinear Quasi-Variational Inclusions 显示文摘 | Agarwal B P CHo Y J Huang N J | 2000 | Appl Math Lett2000，13，： | 2 |
| 4 | 腺癌发生过程中的基因改变显示文摘目前已公认,肿瘤的发生是一个多步骤的过程,在这一过程中基因异常改变的积累,最终导致肿瘤表型的出现.基因改变导致肿瘤发生已经不是一个新假说了,很早就已发现了癌症的遗传易感性,癌细胞中染色体发生的改变,以及化学致癌剂引起的DNA的变化.肿瘤发生时的基因水平的改变是多种多样的.包括基因扩增、点突变、基因重排以及特殊基因的缺失.最近,作者提出了一个结直肠癌发生的基因改变模型,包括下列几个方面:首先。 | Cho KR Vogelstein B 郑文岭 | 1993 | 国外医学(肿瘤学分册)1993，23，3： | 2 |
| 5 | A study of magnetic and optical properties of Cu-doped ZnO 显示文摘 | LEE H J KIM B S CHO C R | 2004 | Phys Status Solidi B2004，241，7： | 1 |
| 6 | Dispersion polymerization of acrylamide with quaternary ammonium cationic comonomer in aqueous solution显示文摘 | Song B K Cho M S Yoon K J | 2003 | J Appl Polym Sci2003，87，： | 1 |
| 7 | Periodic mesoporous organosilicas with multiple bridging groups and spherical morphology显示文摘 | CHO E B KIM D JARONIEC M | 2007 | Langmuir2007，23，11： | 1 |
| 8 | Application of interactive genetic algorithm to fashion design显示文摘 | Kim H S Cho S B | 2000 | Engineering Applications of Artificial Intelligence2000，13，6： | 1 |
| 9 | An anti-apoptotic protein human survivin is a direct inhibitor of Caspase-3 and-7显示文摘 | Sung B J Cho YS Kim H J Ha NC Hwang JI | 2001 | Biochenistry2001，40，4： | 1 |
| 10 | Chemical profiling and expression profiling during the manufacturing process of Talwan oolong tea 'Oriental Beauty'显示文摘 | CHO J Y MIZUTANI M SHIMIZU B I | 2007 | Bioscience Biotechnology and Biochemistry2007，71，6： | 1 |
| 11 | Initial experience with a gasless unilateral axillo-breast or axillary approach endo- scopic thyroidectomy for papillary thyroid microcarci- noma: comparison with conventional open thyroidectomy显示文摘 | Tae K Ji Y B Cho S H | 2011 | Surg Laparosc Endosc Percutan Tech2011，21，2： | 1 |
| 12 | A grazing incidence X ray streak camera for ultrafast, single-shot measurements显示文摘 | Feng J Engelhorn K Cho B I | 2010 | Appl Phys Lett2010，96，13： | 1 |
| 13 | Colorectal canc-er cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endo-thelial cells显示文摘 | HONG B S CHO J H KIM H | 2009 | BMC Genomics2009，10，： | 1 |
| 14 | A novel gene,Pi40 (t) ,linked to the DNA markers derived from NBS-LRR motifs confers broad spectrum of blast resistance in rice 显示文摘 | Jeung J U Kim B R Cho Y C | 2007 | Theor Appl Genet2007，，115： | 1 |
| 15 | Pediatric pineal tumors: need for a drect surgical approach and compilcations of the occiptal transtentorial approch显示文摘 | SHIN H J CHO B K JUNG H W | 1998 | Childs Nerv Syst1998，14，： | 1 |
| 16 | Recombinant polioviruses expres-sing hepatitis B virus-specific cytotoxic T-lymphocyte epito-pes显示文摘 | Cho SP Lee B Min MK | 2000 | Vaccine2000，18，25： | 1 |
| 17 | Overexpress cyclooxygenase2 is associated with a poor prognosis in patients with squamous cell carcinoma of the treated with radiation and concurrent chemotherapy显示文摘 | Kim Y B Kim G E Cho N H | 2002 | Cancer2002，95，： | 1 |
| 18 | Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a mumber of steel alleses显示文摘 | Copeland N C Gilbert D J Cho B C | 1990 | Cell1990，63，： | 1 |
| 19 | A novel electrochemical detection method for aptamer biosensors显示文摘 | Bang G S Cho S Kim B G | 2005 | Biosensors and Bioelectronics2005，21，： | 1 |
| 20 | Analysis of difference fairing based on DFT-filter 显示文摘 | Cho S K Choi B K | 2001 | Computer-Aided Design2001，33，1： | 1 |
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