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| 1 | Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence显示文摘AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer. METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were analyzed.RESULTS: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as 'front-positive' and in 41% as 'front-negative'. The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the 'front-positive' tumors. CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease. | Suvi Tuulia Avoranta Eija Annika Korkeila Kari Juhani Syrjnen Seppo Olavi Pyrhnen Jari Toivo Tapio Sundstrm | 2012 | World Journal of Gastroenterology2012，18，33： | 9 |
| 2 | Prevalence of anal fistula in the United Kingdom显示文摘BACKGROUND Anal fistula is a pathological connection between the anal canal and perianal skin, which most commonly develops from an infected anal crypt. While the majority of anal fistulas are idiopathic, they are also associated with Crohn’s disease (CD) and other inflammatory conditions. The prevalence of anal fistula is estimated to be 1-2 per 10000 patients, but population-based studies on anal fistula epidemiology are limited and outdated. AIM To assess the prevalence of anal fistula and relevant comorbidities, with and without CD in the United Kingdom and Europe. METHODS A retrospective population-representative observational cohort study was performed in The Health Improvement Network (THIN), a United Kingdom primary care database. Mid-year point prevalence of anal fistula was calculated on the first of July for each year between 2014 and 2017. Estimates were calculated for anal fistula overall and by CD status and standardized to the United Kingdom and European population. Prevalence of relevant comorbidities including lymphogranuloma venereum, hidradenitis suppurativa, anal presentation of sexually transmitted diseases, diabetes mellitus, and radiation in the pelvic area was reported. RESULTS The United Kingdom-standardized overall point prevalence of anal fistula was 1.80 (95%CI: 1.65-1.94) per 10000 patients in 2017, while the Europe standardized estimate was 1.83 (95%CI: 1.68-1.98) per 10000 patients. Both these standardized point prevalence estimates ranged from 1.89 to 2.36 between 2014-2016. The United Kingdom-standardized point prevalence of anal fistula without CD was 1.35 (95%CI: 1.23-1.48) per 10000 patients, while the Europe-standardized estimate was 1.39 (95%CI: 1.26-1.52) per 10000 patients. In contrast, the standardized point prevalence estimate of anal fistula with CD was lower for both United Kingdom and Europe (0.44;95%CI United Kingdom: 0.37-0.52, 95%CI Europe: 0.37-0.51) per 10000 patients in 2017. In 2017, 19% of anal fistula patients without CD and 13% of anal fistula patients with CD had at least one relevant comorbidity. These results show that anal fistulas are infrequent in the general population. 24.5% of prevalent anal fistulas are associated with CD, but other potentially etiological comorbidities are rare. CONCLUSION This real-world evidence study estimated the United Kingdom-standardized prevalence of anal fistula was 1.80 per 10000 patients in 2017. Approximately 25% of cases may be associated with CD, while other comorbidities are rare. | Suvi RK Hokkanen Naomi Boxall Javaria Mona Khalid Dimitri Bennett Haridarshan Patel | 2019 | World Journal of Clinical Cases2019，7，14： | 7 |
| 3 | Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure显示文摘AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to 2005.Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver diseases.The 3-year outcomes and number of liver transplantations were recorded.All direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control patients.The health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) questionnaire.The HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was calculated.RESULTS:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish population.Compared to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 years.The incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was 0.66.CONCLUSION:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone. | Taru Kantola Suvi Mklin Anna-Maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi | 2010 | World Journal of Gastroenterology2010，16，18： | 3 |
| 4 | Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia显示文摘AIM:To estimate the prevalence of the lactase non-persistent genotype(C/C-13910)in a northern Russian population in accordance with ethnicity,and to evaluate self-reported milk consumption depending on lactase activity. METHODS:Blood samples for genotyping lactase activity,defining the C/T-13910 variant by polymerase chain reaction,and direct sequencing were taken from 231 medical students of Russian origin aged 17-26 years. We analyzed milk product consumption by questionnaire which was specially designed for the estimation of milk consumption and abdominal complaints. RESULTS:We found that the prevalence of the C/C-13190 genotype in the northern Russian population was 35.6%.The other genotypes nearby C/T-13910 and associated with lactase activity were not present in the study population.The consumption of milk among people with the non-persistent genotype tended to be lower than among the lactose tolerant subjects,but was not statistically significant.CONCLUSION:An investigation of the lactase persistent genotype in a northern Russian population has not been performed before.The genotype did not affect the consumption of milk products in this population which could be explained by low consumption of milk products among the entire study population. | Yulia Khabarova Suvi Torniainen Hanna Nurmi Irma Jrvel Mauri Isokoski Kari Mattila | 2009 | World Journal of Gastroenterology2009，15，15： | 2 |
| 5 | Screening pretreatmentmethods to enhance the rmophilic anaerobic digestion of pulp and pa-per mill wastewater treatment secondary sludge显示文摘 | Suvi Bayr Prasad Kaparaju Jukka Rintala | 2013 | Chemical Engi-neering Journal2013，，223： | 1 |
| 6 | Revisiting ectomycorrhizal fungi of the genus alnus:differential host specificity,diversity and deter-minants of the fungal community显示文摘 | Tedersoo L Suvi T Jairus T | 2009 | New Phytologist2009，182，3： | 1 |
| 7 | Transforming growth factor - β - induced alpha - smooth muscle cell actin ex- pression in renal proximal tubular ceils is regulated by p38 βmitogen - activated protein kinase, extracellular, signal - regula- ted protein kinasel, 2 and the Smad signalling duringepithelial myofibroblast transdifferentiation 显示文摘 | Attila Sebe Suvi - Katri Leivonen Attila Fintha | 2008 | Nephrol Dial Transplant2008，23，5： | 1 |
| 8 | Wood Resin in Acacia mangium and Acacia crassicarpa wood and knots显示文摘 | SUVI p | | 0，，02： | 1 |
| 9 | Diversity and community structures of ectomycorrhizal fungi in a wooded meadow显示文摘 | Tedersoo L Suvi T Larsson E | 2006 | Mycological Research2006，110，： | 1 |
| 10 | The effect of midlife physical activity on structural brain changes in the elderly显示文摘 | Suvi Rovio Gabriela Spulber Lasse J. Nieminen Eini Niskanen Bengt Winblad Jaakko Tuomilehto Aulikki Nissinen Hilkka Soininen Miia Kivipelto | 2008 | Neurobiology of Aging2008，，11： | 1 |
| 11 | Problems in managing internal development projects in multi-project environments 显示文摘 | Suvi Elonen Karlos A Artto | 2003 | Intemational Journal of Project Management2003，21，6： | 1 |
| 12 | Phenolic compounds and expression of 4CL genes in Silver Birch clones and Pt4CLI a Lines 显示文摘 | Suvi S Terhi H Heidi T | 2014 | PLOS ONE2014，9，12： | 1 |
| 13 | An Efficient Procedure for Identifying the Prediction Model Between Residual Stress and Barkhausen Noise显示文摘 | Aki Sorsa Kauko Leiviska Suvi Santa-aho | 2013 | J Nondestruct Eval2013，32，： | 1 |
| 14 | Wood Resin in Acacia Mangium and Acacia Crassicarpa Wood and Knots显示文摘 | Suvi pietartnen | 2004 | Appita2004，57，2： | 1 |
| 15 | The reaction of hexamethyldisilazane and subsequent oxidation of trimethylsilyl groups on silica studied by snlid-state NMR and FTIR显示文摘 | HAUKKA Suvi ROOT Andrew | 1994 | J Phys Chem1994，98，： | 1 |
| 16 | Sustainability and industrialsymbiosis-The evolution of a Finnish forest industry complex显示文摘 | Suvi Pakarinen Tuomas Mattila Matti Melanen Ari Nissinen Laura Sokka | 2010 | Journal of Resources Conservationand Recycling2010，54，12： | 1 |
| 17 | Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD)显示文摘 | Suvi Torniainen Roberta Freddara Taina Routi | 2009 | BMC Gastroenterology2009，9，： | 1 |
| 18 | Lactase non-persistence and milk consumption in Estonia显示文摘AIM: To defi ne the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non- persistent subjects in Estonia. METHODS: We genotyped 355 Estonians by polymerase chain reaction and direct sequencing. Milk consumption was analyzed by a questionnaire, specially developed to analyze milk consumption and abdominal complaints. RESULTS: The frequency of the genotype of the C/ C-13910 (lactase non-persistence) was found to be 24.8% in native Estonians. No other single nucleotide polymorphisms covering the region of 400 bp adjacent to the C/T-13910 variant were found. Lactase non- persistence subjects were found to consume less milk than lactase persistence subjects. CONCLUSION: The frequency of lactase non- persistence defi ned by the C/C-13910 genotype confi rms the results of the previous studies based on indirect methods of determining hypolactasia. Milk consumption of lactase non-persistence subjects is consistent with previously reported figures of adult-type hypolactasia in Estonia. However, lactase non-persistence does not prevent the intake of milk in many adults. | Margus Lember Suvi Torniainen Mart Kull Riina Kallikorm Peeter Saadla Tarvo Rajasalu Hanna Komu Irma Jrvel | 2006 | World Journal of Gastroenterology2006，12，45： | 1 |
| 19 | Communication strategies to overcome functional and psychological resistance to Intemet banking显示文摘 | Tommi Laukkanen Suvi Sinkkonen Pekka Laukkanen | 2009 | International Journal of Information Management2009，13，： | 1 |
| 20 | Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpresslng human alpha- synuclein 显示文摘 | Lakso Merja Vartiainen Suvi Moilanen Anu-Maarit | 2003 | Journal of neurochemistry2003，86，1： | 1 |
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