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| 1 | Biliary strictures complicating living donor liver transplantation:Problems,novel insights and solutions显示文摘Biliary stricture complicating living donor liver transplantation(LDLT) is a relatively common complication, occurring in most transplant centres across the world. Cases of biliary strictures are more common in LDLT than in deceased donor liver transplantation. Endoscopic management is the mainstay for biliary strictures complicating LDLT and includes endoscopic retrograde cholangiography, sphincterotomy and stent placement(with or without balloon dilatation). The efficacy and safety profiles as well as outcomes of endoscopic management of biliary strictures complicating LDLT is an area that needs to be viewed in isolation, owing to its unique set of problems and attending complications; as such, it merits a tailored approach, which is yet to be well established. The diagnostic criteria applied to these strictures are not uniform and are over-reliant on imaging studies showing an anastomotic narrowing. It has to be kept in mind that in the setting of LDLT, a subjective anastomotic narrowing is present in most cases due to a mismatch in ductal diameters. However, whether this narrowing results in a functionally significant narrowing is a question that needs further study. In addition, wide variation in the endotherapy protocols practised in most centres makes it difficult to interpret the results and hampers our understanding of this topic. The outcome definition for endotherapy is also heterogenous and needs to be standardised to allow for comparison of data in this regard and establish a clinical practice guideline. There have been multiple studies in this area in the last 2 years, with novel findings that have provided solutions to some of these issues. This review endeavours to incorporate these new findings into the wider understanding of endotherapy for biliary strictures complicating LDLT, with specific emphasis on diagnosis of strictures in the LDLT setting, endotherapy protocols and outcome definitions. An attempt is made to present the best management options currently available as well as directions for future research in the area. | Harshavardhan B Rao Arjun Prakash Surendran Sudhindran Rama P Venu | 2018 | World Journal of Gastroenterology2018，24，19： | 14 |
| 2 | Endoscopic therapy for biliary strictures complicating living donor liver transplantation: Factors predicting better outcome显示文摘AIM To identify factors predicting outcome of endoscopic therapy in bile duct strictures(BDS) post living donor liver transplantation(LDLT).METHODS Patients referred with BDS post LDLT, were retrospectively studied. Patient demographics, symptoms(Pruritus, Jaundice, cholangitis), intra-op variables(cold ischemia time, blood transfusions, number of ducts used, etc.), peri-op complications [hepatic artery thrombosis(HAT), bile leak, infections], stricture morphology(length, donor and recipient duct diameters) and relevant laboratory data both pre-and post-endotherapy were studied. Favourable response to endotherapy was defined as symptomatic relief with > 80% reduction in total bilirubin/serum gamma glutamyl transferase. Statistical analysis was performed using SPSS 20.0.RESULTS Forty-one patients were included(age: 8-63 years). All had right lobe LDLT with duct-to-duct anastomosis. Twenty patients(48.7%) had favourable response to endotherapy. Patients with single duct anastomosis, aggressive stent therapy(multiple endoscopic retrogradecholagiography, upsizing of stents, dilatation and longer duration of stents) and an initial favourable response to endotherapy were independent predictors of good outcome(P < 0.05). Older donor age, HAT, multiple ductal anastomosis and persistent bile leak(> 4 wk post LT) were found to be significant predictors of poor response on multivariate analysis(P < 0.05). CONCLUSION Endoscopic therapy with aggressive stent therapy especially in patients with single duct-to-duct anastomosis was associated with a better outcome. Multiple ductal anastomosis, older donor age, shorter duration of stent therapy, early bile leak and HAT were predictors of poor outcome with endotherapy in these patients. | Harshavardhan B Rao Hasim Ahamed Suprabha Panicker Surendran Sudhindran Rama P Venu | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 3 |
| 3 | A role for Wnt-4 in renal fibrosis显示文摘 | Surendran K McCaul S P Simon T C | 2002 | Am J Physiol Renal Physiol2002，282，3： | 1 |
| 4 | Isolation and characterization of Vibrio parahaemolyticus from seafoods along the southwest coast of India显示文摘 | Chakraborty R Surendran P Joseph T | 2008 | World J Microb Blot2008，24，10： | 1 |
| 5 | Microbiological changes in farm reared freshwater prawn (Macrobrachium rosenbergii de Man) in ice显示文摘 | LALITHA K V SURENDRAN P K | 2006 | Food Control2006，17，： | 1 |
| 6 | Microbiological changes in farm reared freshwater prawn (Macrobrachium rosenbergii de Man) in ice显示文摘 | Lalitha K V Surendran P K | 2006 | Food Control2006，17，10： | 1 |
| 7 | Microbiological changes in farm reared freshwater prawn (Macrobrachium rosenbergii de Man) in ice显示文摘 | LALITHA K V SURENDRAN P K | 2006 | Food Control2006，17，10： | 1 |
| 8 | Studies on spoilage of commercially important tropical fishes under iced storage显示文摘 | Surendran P K Jose J Shenoy A V | 1989 | Fish Resources1989，7，： | 1 |
| 9 | Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia 显示文摘 | SURENDRAN R P VISSER M E HEEMELAAR S | 2012 | J Intern Med2012，272，2： | 1 |
| 10 | Studies on spoilage of commercially important tropical fishes under iced storage 显示文摘 | Surendran P K Jose J Shenoy A V | 1989 | Fish Res1989，7，： | 1 |
| 11 | Studies on spoilage of commercially important tropical fishes under iced storage显示文摘 | Surendran P K Joseph J Shenoy A V | 1989 | Fish Res1989，7，： | 1 |
| 12 | (1–x)MgA12O4-xTiO2 dielectircs for microwave and millimeter waveapplications显示文摘 | SURENDRAN K P BIJUMON P V MOHANAN P | 2005 | Appl Phys Mater Sci Process2005，81，82： | 1 |
| 13 | Ab-initio Calculations on the Modulation of Electronic Band gap of Photocatalytic Semiconductors显示文摘 | Surendran M S P C | 2012 | Nova Gorica University of Nova Gorica Graduate School2012，，： | 1 |
| 14 | Studies on spoilage of commercially important tropical fishes under iced storage 显示文摘 | Surendran P K Jose J Shenoy A V | 1989 | Fish Res1989，7，： | 1 |
| 15 | Drip fertigation effects on yield,nutrient uptake and sei| fextility of Bt Cotton in semi arid tropics 显示文摘 | Jayakumar M Surendran U Manickasundaram P | 2014 | International Journal of Plant Production2014，8，3： | 1 |
| 16 | Temperature stable low loss ceramic dielectrics in(l-x)ZnA12O4-xTiO2 system for microwave substrate applications 显示文摘 | SURENDRAN K P SANTHA N MOHANAN P | 2004 | Eur Phys J B2004，41，3： | 1 |
| 17 | Low loss dielectrics in Ba[(Mg1/3Ta2/3)1-xTix]O3 and Ba[(Mg1-xZnx)1/3Ta2/3]O3 systems显示文摘 | SURENDRAN K P SEBASTIAN M T | | 0，，11： | 1 |
| 18 | (1-x)MgAl2O4-xTiO2 dielectrics for microwave and millimeter wave applications 显示文摘 | SURENDRAN K P BIJUMON P V MOHANAN P | 2005 | Appl Phys A2005，81，4： | 1 |
| 19 | SrTiO3-filled PTFE composite laminates for microwave substrate applications显示文摘 | Surendran R Kodakkattu P M Kunnathodi V R | | 0，，05： | 1 |
| 20 | (1-x)MgAl2O4-xTiO2 dielectrics for microwave and millimeter wave applications 显示文摘 | BIJUMON P V SURENDRAN K P MOHANAN P | 2005 | J Appl Phys2005，81，： | 1 |
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