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| 1 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
| 2 | Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hormone plasma levels in female swimmers显示文摘 | Mestre-Alfaro A Ferrer MD Sureda A | 2011 | Eur J Appl Physiol2011，111，9： | 1 |
| 3 | Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8 显示文摘 | Gutlerrez C J Sureda FX Romeu M | 2007 | J Pineal Res2007，42，4： | 1 |
| 4 | Effects of long- term silymarin oral supplementation on the blood bioche- mical profile of rainbow trout (Oncorhynchus mykiss) 显示文摘 | Banaee M Sureda A Mirvaghefi A | 2011 | Fish Physiol Biochem2011，37，4： | 1 |
| 5 | Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine 显示文摘 | Tejada S Sureda A Roca C etal | 2007 | Brai~ Res Bull2007，9，4： | 1 |
| 6 | Evaluation of free radical production, mitochondrial membrane potential and cytoplasmic calcium in mammalian neurons by flow cytometry 显示文摘 | Sureda FX Gabriel C Comas J | 1999 | Brain Res Brain Res Protoc1999，4，3： | 1 |
| 7 | Contrast enhanced gray-scale sonography in assessment of joint vascularity in rheumatoid arthritis: results from the IACUS study group显示文摘 | Andrea Klauser Johannes Demharter Armanda Marchi Delia Sureda Antonio Barile Carlo Masciocchi Carlo Faletti Michael Schirmer Timm Kleffel Klaus Bohndorf | 2005 | European Radiology2005，，12： | 1 |
| 8 | High-dose therapy intensification compared with continued standard chemotherapy in multiple nayeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA 显示文摘 | BLADE J ROSINOL L SUREDA A | 2005 | Blood2005，106，12： | 1 |
| 9 | Acontinnousspertrum of hyprcoagui-lability exists in acute nonlymphoblast leukemia显示文摘 | Sureda A Garcia Frade LJ Torrado MC | 1992 | Acta Hacemotol1992，88，2： | 1 |
| 10 | Immune response to exer- cise in elite sportsmen during the competitive season显示文摘 | Cordova A Sureda A Tur J A | 2010 | J Physiol Biochem2010，66，1： | 1 |
| 11 | Allogeneic stem cell transplantation after reduced-intensity conditioning in lymphoid malignancies显示文摘 | A. Sureda N. Schmitz | 2003 | Annals of Hematology2003，，1： | 1 |
| 12 | Meropenem versus ceftazidime plus amikacin in the treatment of fe- brile episodes in neutropenic patients: A randomized study 显示文摘 | De la Camara R Figuera A Sureda A | 1997 | Haematologica1997，82，6： | 1 |
| 13 | Allogeneic stem cell transplantation after reduced-intensity conditioning in lymphoid malignancies 显示文摘 | Sureda A Schmitz N | 2003 | Ann- Hematol2003，82，1： | 1 |
| 14 | Determination of nitric ox- ide generation in mammalian neurons using dichlorofluoreacin dlace- rate and flow cytometry 显示文摘 | Gabriel C Camlns A Sureda FX | 1997 | Journal of Pharmacological and Toxico- logical Methods1997，38，2： | 1 |
| 15 | The evolving role of stem cell transplants in lymphomas显示文摘 | Jantunen E Sureda A | 2012 | Biol Blood Marrow Transplant2012，18，4： | 1 |
| 16 | Contrast enhanced gray-scale sonography in assessment of joint vascularity in rheumatoid arthritis: results from the IACUS study group显示文摘 | Andrea Klauser Johannes Demharter Armanda Marchi Delia Sureda Antonio Barile Carlo Masciocchi Carlo Faletti Michael Schirmer Timm Kleffel Klaus Bohndorf | 2005 | European Radiology2005，，12： | 1 |
| 17 | Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8显示文摘 | Gutierrez-Cuesta J Sureda F X Romeu M | 2007 | J Pineal Res2007，42，4： | 1 |
| 18 | Acontinnous spertrum of hyprcoagui-lability exists in acute nonlymphoblast leukemia显示文摘 | Sureda A Garcia Frade LJ Torrado MC | 1992 | Acta Hacemotol1992，88，2： | 1 |
| 19 | Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine显示文摘 | TEJADA S SUREDA A ROCA C | 2007 | Brain Res Bull2007，71，4： | 1 |
| 20 | Prognostic fac- tors affecting long - term outcome after stem cell transplantation in Hodgkin's lym- phoma autografted after a first relapse 显示文摘 | SUREDA A CONSTANS M IRIONDO A | 2005 | Ann Oncol2005，16，4： | 1 |
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