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| 1 | Nucieocytoplasmic Shuttling of Geminivirus C4 Protein Mediated by Phosphorylation and Myristoylation Is Critical for Viral Pathogenicity显示文摘Many geminivirus C4 proteins induce severe developmental abnormalities in plants.We previously demon- strated that Tomato leaf curl Yunnan virus (TLCYnV)C4 induces plant developmental abnormalities at least partically by decreasing the accumulation of NbSKη,an ortholog of Arabidopsis BIN2 kinase involved in the brassinosteroid signaling pathway,in the nucleus through directing it to the plasma membrane.However, the molecular mechanism by which the membrane-associated C4 modifies the localization of NbSKη in the host cell remains unclear.Here,we show that TLCYnV C4 is a nucleocytoplasmic shuttle protein,and that C4 shuttling is accompanied by nuclear export of NbSKTI.TLCYnV C4 is phosphorylated by NbSKη in the nucleus,which promotes myristoylation of the viral protein.Myristoylation of phosphorylated C4 favors its interaction with exportin-α(XPO I);which in turn facilitates nuclear export of the C4/NbSKTI complex. Supporting this model,chemical inhibition of N-myristoyltransferases or exportin-α enhanced nuclear retention of C4,and mutations of the putative phosphorylation or myristoylation sites in C4 resulted in increased nuclear retention ofrC4 and thus decreased severity of C4-induced developmental abnormalities. The impact of C4 on development is also lessened when a nuclear localization signal or a nuclear export signal is added to its C-terminus,restricting it to a specific cellular niche and therefore impairing nucleocytoplasmic shuttling.Taken together,our results suggest that nucleocytoplasmic shuttling of TLCYnV C4,enabled by phosphorylation by NbSKη,myristoylation,and interaction with exportin-α is critical for its function as a pathogenicity factor. | Yuzhen Mei Yaqin Wang Tao Hu Xiuling Yang Rosa Lozano-Duran Garry Sunter Xueping Zhou | 2018 | Molecular Plant2018，11，12： | 5 |
| 2 | A theory for record linkage显示文摘 | Fellegi IP Sunter AB | 1969 | J AmStat Assoc1969，64，328： | 1 |
| 3 | Diurnal variation in orexin A immunoreactivity and preproorexin mRNA in the rat central nervous system显示文摘 | TAHERI S SUNTER D DAKIN C | 2000 | Neuroscience Letters2000，279，2： | 1 |
| 4 | Mechano- transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) Ⅰ receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling 显示文摘 | SUNTERS A ARMSTRONG VJ ZAMAN G | 2010 | J Biol Chem2010，285，12： | 1 |
| 5 | Intracerebroventricular injection of apelin-13 reduces food intake in the rat显示文摘 | Sunter D Hewson A K Dickson S L | 2003 | Neurosci Lett2003，353，1： | 1 |
| 6 | Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt显示文摘 | Sunters A Madureir PA Pomeranz KM | | 0，，01： | 1 |
| 7 | A theory for record linkage显示文摘 | FELLEGI I P SUNTER A B | | 0，，328： | 1 |
| 8 | A Theory for Record Linkage 显示文摘 | Fellegi I Sunter A | 1969 | JASA1969，64，328： | 1 |
| 9 | Obesity and obstructivesleep apnea syndrome显示文摘 | Acloglu E Yigit O Volkan Sunter A | 2010 | J Otolaryngol Head Neck Surg2010，39，6： | 1 |
| 10 | Emergency service use by older people in Samsun,Turkey显示文摘 | Dundar C Sunter AT Canbaz S | 2006 | Adv Ther2006，，1： | 1 |
| 11 | Paclitaxel induced nuclear transl ocation of FOXO3a in breast cancer cells is mediated by Cjun NH2 -- terminal kinase and Akt显示文摘 | Sunters A Madureira PA Pomeranz KM | 2006 | Cancer Res2006，66，1： | 1 |
| 12 | Stereotaxic de- Iiery of corticosterone to the amydala modulates colonic sensitiity in rats 显示文摘 | Greenwood - Van Meereld B Gltlson M Sunter W | 2001 | Brain Res2001，893，12： | 1 |
| 13 | A theory for record linkage显示文摘 | Fellegi I P Sunter A B | 1969 | Journal of the American Statistical Association1969，64，328： | 1 |
| 14 | The prevalence of 'pigeon breeder's disease' in a Turkish city and review of the literature 显示文摘 | Uzun O Yilmaz DK Sunter AT | 2011 | Lung2011，189，7： | 1 |
| 15 | DNA sequence essential for the replication of the B genome component of tomato golden mosaic virus 显示文摘 | Revington G N Sunter G Bisaro D M | 1989 | Plant Cell1989，1，： | 1 |
| 16 | Paclitaxel-induced nuclear translocation of Foxo3a in breast cancer is mediated by c-Jun NH2-terminal kinase and Akt显示文摘 | Madureira P A Pomeranz K M | 2006 | Cancer Res2006，66，1： | 1 |
| 17 | Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer:regulation by methylation显示文摘 | ZHAO C LAM E W SUNTERS A | 2003 | Oncogene2003，22，48： | 1 |
| 18 | ICI182,780 induces p21^waf1 gene transcription through releasing histone deaeetylase 1 and estro-gen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF- 7 breast cancer cell line 显示文摘 | Varshochi R Halirn F Sunters A | 2005 | J Biol Chem2005，280，5： | 1 |
| 19 | Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation显示文摘 | Zhao C Lain EW Sunters A | 2003 | Oncogene2003，22，48： | 1 |
| 20 | Expression of estrogen re- ceptor beta isoforms in normal breast epithelial cells and breast canc- er: regulation by methylation 显示文摘 | ZHAO C LAME W SUNTERS A | 2003 | Oncogene2003，22，48： | 1 |
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