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| 1 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 2 | Narrow pelvic inlet plane area and obesity as risk factors for anastomotic leakage after intersphincteric resection显示文摘BACKGROUND Intersphincteric resection(ISR)has been increasingly used as the ultimate sphincter-preserving procedure in extremely low rectal cancer.The most critical complication of this technique is anastomotic leakage.The incidence rate of anastomotic leakage after ISR has been reported to range from 5.1%to 20%.AIM To investigate risk factors for anastomotic leakage after ISR based on clinicopathological variables and pelvimetry.METHODS This study was conducted at Department of Colorectal Surgery,Japanese Red Cross Medical Center,Tokyo,Japan,with a total of 117 patients.We enrolled 117 patients with extremely low rectal cancer who underwent laparotomic and laparoscopic ISRs at our hospital.We conducted retrospective univariate and multivariate regression analyses on 33 items to elucidate the risk factors for anastomotic leakage after ISR.Pelvic dimensions were measured using threedimensional reconstruction of computed tomography images.The optimal cutoff value of the pelvic inlet plane area that predicts anastomotic leakage was determined using a receiver operating characteristic(ROC)curve.RESULTS We observed anastomotic leakage in 10(8.5%)of the 117 patients.In the multivariate analysis,we identified high body mass index(odds ratio 1.674;95%confidence interval:1.087-2.58;P=0.019)and smaller pelvic inlet plane area(odds ratio 0.998;95%confidence interval:0.997-0.999;P=0.012)as statistically significant risk factors for anastomotic leakage.According to the receiver operating characteristic curves,the optimal cutoff value of the pelvic inlet plane area was 10074 mm2.Narrow pelvic inlet plane area(≤10074 mm2)predicted anastomotic leakage with a sensitivity of 90%,a specificity of 85.9%,and an accuracy of 86.3%.CONCLUSION Narrow pelvic inlet and obesity were independent risk factors for anastomotic leakage after ISR.Anastomotic leakage after ISR may be predicted from a narrow pelvic inlet plane area(≤10074 mm2). | Akira Toyoshima Toshihiro Nishizawa Eiji Sunami Ryuji Akai Takahiro Amano Akiyoshi Yamashita Shin Sasaki Takeshi Endo Yoshihiro Moriya Osamu Toyoshima | 2020 | World Journal of Gastrointestinal Surgery2020，12，10： | 4 |
| 3 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 4 | Influence of Microstructures on Aerodynamic Characteristics for Dragonfly Wing in Gliding Flight显示文摘In this paper, the functionalities of microstructures for dragonfly wing during gliding flight are investigated. Three dragonfly-mimic airfoil-shaped wings with hybrid structures were designed and fabricated as: flat wing, zigzag-edged wing and zigzag-edged wing with pillar structure. Based on the wind tunnel experiments, the zigzag-edged wing structure significantly reduces the drag force in the gliding flight. Moreover, the drag reduction is more effective on the combination of the surface pillar and zigzag-edged structure. In addition, the zigzag-edged wing structure has less influence of Karman vortex street, and the surface pillars reduce the frictional drag and stabilized the streamline in the lower vortex region. Overall, the microstructure of the dragonfly wing is an important element in the aerodynamic study. These findings can enhance the knowledge of insect-mimic wing structure and facilitate the application of Micro Air Vehicle (MAV) in the gliding flight. | Sheng Zhang Masayuki Ochiai Yuta Sunami Hiromu Hashimoto | 2019 | Journal of Bionic Engineering2019，16，3： | 2 |
| 5 | Slitventricle syndrome aftercyst-peritonealshunt ing fortempo- ralarachnoid cystin children-a clinicalentity difficultto detecton neuroimaging study 显示文摘 | Sunami K Saeki N Sunada S | 2002 | Brain Dev2002，，24： | 1 |
| 6 | Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery显示文摘 | Sunami K Takeda Y Hashimoto M | 2000 | Crit Care Med2000，28，8： | 1 |
| 7 | Multi marker circulat- ing DNA assay for assessing blood of prostate cancer patients 显示文摘 | Sunami E $hinozaki M Higano CS | 2009 | ClinChem2009，55，3： | 1 |
| 8 | Racemic structure and optical resolution by preferential crystallization of DLcysteine salts of substituted benzenesulfonic acids显示文摘 | Shiraiwa T Tazoh H Sunami M | 1987 | Bull Chem Soc Jpn1987，60，： | 1 |
| 9 | MRI findingsand clinical manifestations in Rathke's cleft cyst显示文摘 | Saeki N Sunami K SugayaY | 1999 | Acta Neurochir1999，141，10： | 1 |
| 10 | ICAM-1 (intercellular adhesion molecule-1) gene transfection inhibits lymphnode metastasis by human gastric cancer cells显示文摘 | Yashiro M Chung KH | 2000 | Jpn J Cancer Res2000，91，9： | 1 |
| 11 | Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to theischemic periphery显示文摘 | Sunami K Takeda Y Hashimoto M | 2000 | Crit Care Med2000，28，8： | 1 |
| 12 | Effect of nonsteroidal anti-inflammatory drug plasters for knee osteoarthritis in Japanese: a randomized controlled trial显示文摘 | Tokuhide Doi Masami Akai Keiji Fujino Yuichi Hoshino Tsutomu Iwaya Yoshifumi Sunami | 2010 | Modern Rheumatology2010，，1： | 1 |
| 13 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation 显示文摘 | SUNAMI T BYRNE N DIEHL R E | 2010 | J Biol Chem2010，285，7： | 1 |
| 14 | One-stage segmental colectomy and primary anastomosis after intraoperative colonic irrigation and total colonoscopy for patients with obstruction due to left-sided colorectal cancer显示文摘 | Sasaki K Kazama S Sunami E | 2012 | Dis Colon Rectum2012，55，1： | 1 |
| 15 | Cyelooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of co]orectal cancer 显示文摘 | Tomozawa S Tsuno N Sunami E | 2000 | Br J Cancer2000，83，3： | 1 |
| 16 | Detection of non- palpable breast cancer in asymptomatic women by using un- enhanced diffusion-weighted and T2-weighted MR imagi -ng:comparison with mammography and dynamic contrast- enhanced MR imaging显示文摘 | Yabuuchi H Matsuo Y Sunami S | 2011 | Eur Radiol2011，21，1： | 1 |
| 17 | Quantification of LINE1 in circulating DNA as a molecular biomarker of breast cancer显示文摘 | Sunami E Vu A T Nguyen S L | 2008 | Ann N YAcad Sci2008，1137，： | 1 |
| 18 | Koch ' s phenomenon after BCG vaccination and the two-step tuberculin test in elementary school children显示文摘 | Igari H Onozaki I Sunami Y | 1998 | Kekkaku1998，73，6： | 1 |
| 19 | Solid-phase synthesis of aryl, heteroaryl, and sterically hindered ,alkyl amines using the Ct rtius rearrangement显示文摘 | Sunami S Ohkubo M | 2009 | Tetrahedron2009，65，： | 1 |
| 20 | MRI findings and clinical manifestations in Rathke's cleft cyst 显示文摘 | Saeki N Sunami K Sugaya Y | 1999 | Acta Neurochir1999，141，10： | 1 |
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