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| 1 | Evaluation of antigenotoxic effects of carotenoids from green algae Chlorococcum humicola using human lymphocytes显示文摘Objective:To identify the available phytochemicals and carotenoids in the selected green algae and evaluate the potential genotoxic/antigenotoxic effect using lymphocytes.Methods:Organic,solvent extracts of Chlorococcum humicola(C.humicola)were used for the phytochemical analysis.The available carotenoids were assessed by HPLC,and LC-MS analysis.The genotoxicity was induced by the benzo(a)pyrene in the lymphocyte culture,the genotoxic and antigenotoxic effects of algal carotenoids with and without genotoxic inducer were evaluated by chromosomal aberration(CA),sister chromatid exchange(SCE)and micronucleus assay(MN).Results:The results of the analysis showed that the algae were rich in carotenoids and fatty acids.In the total carotenoids lutein,β-carotene andα-carotene were found to be present in higher concentration.The frequency of CA and SCE increased by benzo(a)pyrene were significantly decreased by the carotenoids(P<0.05 for CA,P<0.001 for SCE).The MN frequencies of the cells were significantly decreased by the treatment with carotenoids when compared with the positive controls(P<0.05).Conclusions:The findings of the present study demonstrate that,the green algae C.humicola is a rich source of bioactive compounds especially carotenoids which effectively fight against environmental genotoxic agents,the carotenoids itself is not a genotoxic substance and should be further considered for its beneficial effects. | Bhagavathy S Sumathi P | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 3 |
| 2 | The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension:Findings from the Prospective Urban Rural Epidemiology China Study显示文摘Background:Both hypertension and grip strength(GS)are predictors of mortality and cardiovascular disease(CVD),but whether these risk factors interact to affect CVD and all-cause mortality is unknown.This study sought to investigate the associations of GS with the risk of major CVD incidence,CVD mortality,and all-cause mortality in patients with hypertension.Methods:GS was measured using a Jamar dynamometer(Sammons Preston,Bolingbrook,IL,USA)in participants aged 3570 years from 12 provinces included in the Prospective Urban Rural Epidemiology China Study.Cox frailty proportional hazards models were used to examine the associations of GS and hypertension and the outcomes of all-cause mortality and CVD incidence/mortality.Results:Among 39,862 participants included in this study,15,964 reported having hypertension,and 9095 had high GS at baseline.After a median follow-up of 8.9 years(interquartile range,6.79.9 years),1822 participants developed major CVD,and 1250 deaths occurred(388 as a result of CVD).Compared with normotensive participants with high GS,hypertensive patients with high GS had a higher risk of major CVD incidence(hazard ratio(HR)=2.39;95%confidence interval(95%CI):1.863.06;p<0.001)or CVD mortality(HR=3.11;95%CI:1.596.06;p<0.001)but did not have a significantly increased risk of all-cause mortality(HR=1.24;95%CI:0.921.68;p=0.159).These risks were further increased if hypertensive participants whose GS level was low(major CVD incidence,HR=3.31,95%CI:2.604.22,p<0.001;CVD mortality,HR=4.99,95%CI:2.649.43,p<0.001;and all-cause mortality,HR=1.93,95%CI:1.472.53,p<0.001).Conclusion:The present study demonstrates that low GS is associated with the highest risk of major CVD incidence,CVD mortality,and all-cause mortality among hypertensive patients.High levels of GS appear to mitigate long-term mortality risk among hypertensive patients. | Weida Liu Darryl P Leong Bo Hu Lap AhTse Sumathy Rangarajan Yang Wang Chuangshi Wang Fanghong Lu Yindong Li Salim Yusuf Lisheng Liu Wei Li | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 3 | Automatic recommendation of web pages in web usage mining显示文摘 | SUMATHI C P VALLI R P SANTHANAM T | 2010 | International Journal of Computer Science and Engineering2010，2，9： | 1 |
| 4 | Detection of ASPL/TFE3fusion transcripts and the TFE3 antigen in formalin-fixed,paraffin-embedded tissue in a series of 18cases of alveolar soft part sarcoma:useful diagnostic tools in cases with unusual histological features显示文摘 | WILLIAMS A BARTLE G SUMATHI V P | 2011 | Virchows Arch2011，458，： | 1 |
| 5 | Kinetic and equilibrium studies on the biosorption of reactive black 5 dye by Aspergillus foetidus显示文摘 | Rachna P Sumathi S | | 0，，： | 1 |
| 6 | A panel of immnnohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between pri- mary endometrial and endocervical adenocarcinomas显示文摘 | McCluggage W G Sumathi V P McBride H A | 2002 | Int J Gy- necol Pathol2002，21，1： | 1 |
| 7 | Endometrial stromal neoplasmas are immunoreactive with WT- 1 antibody 显示文摘 | Sumathi V P Hussainim A L Connolly L E | 2004 | Int J Gynecol Pathol2004，23，3： | 1 |
| 8 | CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms显示文摘 | Sumathi VP Maxwell P | 2002 | Histopathology2002，41，1： | 1 |
| 9 | Solution to the job shop scheduling prob- lem using Hybrid genetic swarm optimization based on (2:, 1)-in- terval fuzzy processing time显示文摘 | Surekha P Sumathi S | 2011 | European Journal of Scientific Research2011，64，2： | 1 |
| 10 | Utilization of oil palm as a source of renewable energy in Malaysia 显示文摘 | Sumathi S Chai S P Mohamed A R | 2008 | Renewable and Sustainable Energy Reviews2008，12，9： | 1 |
| 11 | Expression of human growth hormone in silkworm larvae through recombinant Bombyx mori nuclear polyhedrosis virus 显示文摘 | SUMATHY S PALHAN V B GOPINATHAN K P | 1996 | Protein Expr Pufif1996，7，3： | 1 |
| 12 | Uterine serous carcinoma and endomeaial intraepithelial carcinoma arising in endometrial polyps: report of 5 cases, including 2 associated with tamoxifen therapy显示文摘 | MCCLUGGAGE W G SUMATHI V P MCMANUS D T | 2003 | Human Pathology2003，34，9： | 1 |
| 13 | Controlled comparison between betamethasone gel and lidocaine jelly applied over tracheal tube to reduce postoperative sore throat,cough,and hoarseness of voice显示文摘 | Sumathi P A Shenoy T Ambareesha M | | 0，，02： | 1 |
| 14 | Solid - state fermentation for the production of Monascus pigments from jaekfruit seed显示文摘 | Sumathy B Carlos R S Ashok P | 2007 | Bioresource Technology2007，98，8： | 1 |
| 15 | Endometrial stromal neoplasms are immunoreactive with WT-1 antibody 显示文摘 | Sumathi V P A1-Hussaini M Connolly L E | 2004 | Int J Gynecol Pathol2004，23，3： | 1 |
| 16 | CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms 显示文摘 | McCluggage WG Sumathi VP Maxwell P | 2001 | Histopathol2001，39，3： | 1 |
| 17 | Solution to multi-depot vehicle rou- ting problem using genetic algorithms 显示文摘 | SUREKHA P Dr SUMATHI S | 2011 | World Applied Program- ruing2011，1，3： | 1 |
| 18 | CD10 is a sensitive and diagnostically useful marker of normal endometrial stroma and of endometrial stromal neoplasms显示文摘 | McCluggage WG Sumathi VP Maxwell P | 2001 | Histopathology2001，39，3： | 1 |
| 19 | Green algae Chlorococcum humicola: a new source of bioactive compounds with antimicrobial activity显示文摘 | Bhagavathy S Sumathi P Bell Jancy Sherene I | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 1 |
| 20 | Automatic facial expression analysis a survey 显示文摘 | Sumathi C P Santhanam T Mahadevi M | 2013 | International Journal ofComputer Science & Engineering Survey2013，3，6： | 1 |
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