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| 1 | PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway显示文摘Our previous studies have showed that C-C motif chemokine ligand 20(CCL20)advanced tumor progression and enhanced the chemoresistance of cancer cells by positively regulating breast cancer stem cell(BCSC)self-renewal.However,it is unclear whether CCL20 affects breast cancer progression by remodeling the tumor microenvironment(TME).Here,we observed that polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)were remarkably enriched in TME of CCL20-overexpressing cancer cell orthotopic allograft tumors.Mechanistically,CCL20 activated the differentiation of granulocyte-monocyte progenitors(GMPs)via its receptor C-C motif chemokine receptor 6(CCR6)leading to the PMN-MDSC expansion.PMN-MDSCs from CCL20-overexpressing cell orthotopic allograft tumors(CCL20-modulated PMN-MDSCs)secreted amounts of C-X-C motif chemokine ligand 2(CXCL2)and increased ALDH+BCSCs via activating CXCR2/NOTCH1/HEY1 signaling pathway.Furthermore,C-X-C motif chemokine receptor 2(CXCR2)antagonist SB225002 enhanced the docetaxel(DTX)effects on tumor growth by decreasing BCSCs in CCL20high-expressing tumors.These findings elucidated how CCL20 modulated the TME to promote cancer development,indicating a new therapeutic strategy by interfering with the interaction between PMN-MDSCs and BCSCs in breast cancer,especially in CCL20high-expressing breast cancer. | Rui Zhang Mengxue Dong Juchuanli Tu Fengkai Li Qiaodan Deng Jiahui Xu Xueyan He Jiajun Ding Jie Xia Dandan Sheng Zhaoxia Chang Wei Ma Haonan Dong Yi Zhang Lixing Zhang Lu Zhang Suling Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 2 | Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis显示文摘Neutrophils are mobilized and recruited to the injured heart after myocardial infarction,and neutrophil count has been clinically implicated to be associated with coronary disease severity.Histidine decarboxylase(HDC)has been implicated in regulating reactive oxidative species(ROS)and the differentiation of myeloid cells.However,the effect of HDC on neutrophils after myocardial infarction remains unclear.Here,we found that neutrophils were disorderly recruited into the ischemic injured area of the myocardium of Hdc deficiency(Hdc^(−/−))mice.Moreover,Hdc deficiency led to attenuated adhesion but enhanced migration and augmented ROS/neutrophil extracellular traps(NETs)production in neutrophils.Hdc^(−/−)mouse-derived NETs promoted cardiomyocyte death and cardiac fibroblast proliferation/migration.Furthermore,protein arginine methyltransferase 1(PRMT1)was increased in Hdc^(−/−)mouse-derived neutrophils but decreased with exogenous histamine treatment.Its expression could be rescued by blocking histamine receptor 1(H1R),inhibiting ATP synthesis or reducing SWItch/sucrose non fermentable(SWI/SNF)chromatin remodeling complex.Accordingly,histamine or MS023 treatment could decrease ROS and NETs ex vivo,and ameliorated cardiac function and fibrosis,along with the reduced NETs in plasma in vivo.Together,our findings unveil the role of HDC in NETosis by histamine–H1R–ATP–SWI/SNF–PRMT1–ROS signaling and provide new biomarkers and targets for identifying and tuning the detrimental immune state in cardiovascular disease. | Zhiwei Zhang Suling Ding Zhe Wang Xiaowei Zhu Zheliang Zhou Weiwei Zhang Xiangdong Yang Junbo Ge | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 3 | Activation of histamine/H R signaling pathway promotes cardiac differentiation and maturation of human induced pluripotent stem cells显示文摘The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC CMs)is crucial for regenerative medicine,disease modeling,drug screening and the study of the development events during cardiac specification.However,their applications have been hampered by the differentiation efficiency,poor maturation and high interline variability.Recent studies have reported that histamine plays important roles in hema topoietic stem cell proliferation and neutrophil maturation.However,its roles in cardiovascular tissue regeneration have not been thoroughly investigated.In the current study,we identified a novel physiological function of the histamine/histamine 1 receptor(H,R)signal in regulating the differentiation of hiPSC-CMs and heart development. | Zhu Xiaowei Ding Suling Zhu Baoling Wang Xiangfei Zou Yunzeng Yang Xiangdong Ge Junbo | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 4 | Advances in TiS_(2) for energy storage,electronic devices,and catalysis:A review显示文摘As the lightest family member of the transition metal disulfides(TMDs),TiS_(2)has attracted more and more attention due to its large specific surface area,adjustable band gap,good visible light absorption,and good charge transport properties.In this review,the recent state-of-the-art advances in the syntheses and applications of TiS_(2) in energy storage,electronic devices,and catalysis have been summarized.Firstly,according to the physical presentation of the TiS_(2) synthesis reaction,it can be divided into a solid phase synthesis,a liquid phase synthesis and a gas phase synthesis.Secondly,we summarize the applications of TiS_(2) in energy storage,electronic devices and catalytic:(1)The applications of TiS_(2) nanostructure in energy storage direction from the aspects of Li-ion battery(LIB),Li–S battery(LSB),Na-ion battery(NIB),K-ion battery(KIB),Mg-ion battery(MIB),solar cells and hydrogen storage;(2)The applications of TiS_(2) nanostructures in various electronic devices from thermoelectric devices,high power lasers and flexible devices;(3)Applications based on energy catalysis and environmental catalysis.Based on the various synthetic technologies and wide applications of TiS_(2),we firmly believe that the challenges of TiS_(2) will be solved and become a hot star material in the future.Finally,we discuss the future scope and the current challenges arising from this fascinating material. | Yunhong Jiang Heping Xie Lu Han Yuan Zhang Yanhuai Ding Suling Shen Bin Chen Meng Ni | 2023 | Progress in Natural Science:Materials International2023，33，2： | 0 |
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