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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Hyperprolactinaemia: a- nalysis of presentation, diagnosis and treatment in the endocrine service of a general hospital显示文摘 | Suliman AM Al-saber F Hayes F | 2000 | Ix Med J2000，93，： | 1 |
| 3 | Hyperprolactinaemia:analysis ofpresentation,diagnosis and treatment in the endocrine service of a general hospital显示文摘 | Suliman AM Al-saber F | 2000 | I r M ed J2000，93，： | 1 |
| 4 | Gross variability in the detection of prolactin in sera containing big big prolactin (macroprolactin) by commercial immunoassays显示文摘 | Smith TP Suliman AM Fahie-Wilson MN | 2002 | J Clin Endocrinol Metab2002，87，12： | 1 |
| 5 | Inoculum production and long-term conservation methods for cucurbits and tomato powdery mildews显示文摘 | Bardin M Suliman ME Sage-palloix AM | 2007 | Mycological Research2007，111，6： | 1 |
| 6 | Frequent misdiagnosis and mismanagement of hyperprolactinemia patients be fore introduction of macroprolactin:Application of a new strict laboratory definition of macroprolactinemia显示文摘 | Suliman AM Smith TP Gibney J Mc Kenna TJ | 2003 | Clin Chem2003，49，9： | 1 |
| 7 | The low-dose ACTH test does not provide a useful assessment of the hypothalamic-pituitary- adrenal axis in secondary adrenal insufficiency 显示文摘 | Suliman AM Smith TP Labib M | 2002 | Clin Endocrinol (Oxf)2002，56，4： | 1 |
| 8 | Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia显示文摘 | Folz RJ Abushamaa AM Suliman HB | 1999 | J Clin Invest1999，103，7： | 1 |
| 9 | Frequent misdiagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening:application of a new strict laboratory defini- tion of macroprolactinemia 显示文摘 | Suliman AM Smith TP Gibney J | 2003 | Clin Chem2003，49，9： | 1 |
| 10 | The low-dose ACTH test does not provide a useful assessment of the hypothalamic-pituitary-adrenal axis in secondary adrenal insufficiency 显示文摘 | Suliman AM Smith TP Labib M | 2002 | Clin Endocrinol (Oxf)2002，56，4： | 1 |
| 11 | Extracellular superoxide dismutase in the airways of transgenic mice reduces inflamma- tion and attenuates lung toxicity following hyperoxia 显示文摘 | Folz R J Abushamaa AM Suliman HB | 1999 | J Clin Invest1999，103，7： | 1 |
| 12 | Hyperprolactinaemia: analysis of presentation, diagnosis and treatment in the endocrine service of a general hospital显示文摘 | Suliman AM Al-saber F Hayes F | 2000 | Ir Med J2000，93，： | 1 |
| 13 | Gross variability in the detection of prolactin in sera containing big big prolactin (macroprolactin) by commercial immunoassays 显示文摘 | Smith TP Suliman AM Fahie-Wilson MN | 2002 | J Clin Endocrinol Metab2002，87，12： | 1 |
| 14 | Frequent misdiagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinemia 显示文摘 | Suliman AM Smith TP Gibney J | 2003 | Clin Chem2003，49，9： | 1 |
| 15 | Effects of short-and long-term rat hind limb immobilization on spinal cord insulin-like growth factor-I and its receptor显示文摘 | Suliman IA Lindgren JU Elhassan AM | | 0，，01： | 1 |
| 16 | Extracellular superoxide dismutase in the airway of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia显示文摘 | Folz R J Abshamaa AM Suliman HG | 1999 | Clin Invest1999，103，： | 1 |
| 17 | Extracellular superoxide dismutasc in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia显示文摘 | Folz R J Abushamaa AM Suliman HB | 1999 | J Clin Invest1999，103，7： | 1 |
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