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| 1 | Changes in China’s lakes: climate and human impacts显示文摘Lakes have played a critical role in providing water and ecosystem services for people and other organisms in China for millennia.However,accelerating climate change and economic boom have resulted in unprecedented changes in these valuable lakes.Using Landsat images covering the entity of the country,we explored the changes in China’s lakes and the associated driving forces over the last 30 years(i.e.mid-1980 s to 2015).We discovered that China’s lakes have changed with divergent regional trends:in the sparsely populated Tibetan Plateau,lakes are abundant and the lake area has increased dramatically from 38596 to46831 km^2(i.e.increased by 8235 km^2,or 21.3%),whereas,in the densely populated northern and eastern regions,lakes are relatively scarce and the lake area has decreased from 36659 to 33657 km^2(i.e.decreased by 3002 km^2,or 8.2%).In particular,severe lake decreases occurred in the Mongolia-Xinjiang Plateau and the Eastern Plain(-2151 km^2).Statistical analyses indicated that climate was the most important factor controlling lake changes in the Tibetan Plateau,the Yun-Gui Plateau and the Northeast Plain.However,the strength of climatic control on lake changes was low in the Eastern Plain and the Mongolia-Xinjiang Plateau,where human activities,e.g.impoldering,irrigation and mining,have caused serious impacts on lakes.Further lake changes will exacerbate regional imbalances between lake resources and population distribution,and thus may increase the risk of water-resource crises in China. | Shengli Tao Jingyun Fang Suhui Ma Qiong Cai Xinyu Xiong Di Tian Xia Zhao Leqi Fang Heng Zhang Jiangling Zhu Shuqing Zhao | 2020 | National Science Review2020，7，1： | 14 |
| 2 | Identification and Typing of Respiratory Adenoviruses in Guangzhou, Southern China Using a Rapid and Simple Method显示文摘Human adenoviruses (HAdVs), especially HAdV-B3, -E4 and -B7, are associated with Acute Respiratory Disease in Chinese children, and occasionally in adults. In order to establish and document the profiles of the respiratory adenovirus pathogen among children in Guangzhou, Southern China, a rapid, simple and practical method for identification and typing of respiratory adenoviruses was developed and evaluated. One pair of universal PCR primers was designed according to the conserved region of the hexon gene, which can detect not only HAdV-B3, -E4 and -B7, but also HAdV-B14, -F40 and -F41, with a specific 300bp PCR product. Three pairs of type-specific PCR primers were also designed according to the hypervariable regions of the hexon gene to type HAdV-B3, -E4 and -B7 by three independent PCR reactions, making it easy to optimize the PCR conditions. By using this method, one hundred throat swab specimens collected during Oct 2010 to Dec 2011 and suspected of being positive for adenoviral infection were identified and typed for adenoviruses. Of these samples, fifty-five were adenovirus-positive. The most common HAdV type was HAdV-B3, identified in 92.7% of samples, which is not only consistent with the data reported in 2004-2006, but also consistent with the recent report in Hangzhou, eastern China, indicating that HAdV-B3 has been circulating in Guangzhou, and maybe in eastern China, for many years. The method for the respiratory adenovirus identification and typing we developed is rapid, simple and practical, which has a potential in the real-time surveillance of circulating adenovirus strains and also to provide etiological evidence for the adenovirus-relative disease control and prevention in China. | Guiyuan Han Hongling Niu Suhui Zhao Bing Zhu Changbing Wang Yungang Liu Mingjie Zhang Shu Yang Feitong Liu Chengsong Wan Qiwei Zhang | 2013 | Virologica Sinica2013，28，2： | 10 |
| 3 | Family-level leaf nitrogen and phosphorus stoichiometry of global terrestrial plants显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations are critical for photosynthesis, growth, reproduction and other ecological processes of plants. Previous studies on large-scale biogeographic patterns of leaf N and P stoichiometric relationships were mostly conducted using data pooled across taxa, while family/genus-level analyses are rarely reported. Here, we examined global patterns of family-specific leaf N and P stoichiometry using a global data set of 12,716 paired leaf N and P records which includes 204 families, 1,305 genera, and 3,420 species. After determining the minimum size of samples(i.e., 35 records), we analyzed leaf N and P concentrations, N:P ratios and N^P scaling relationships of plants for 62 families with 11,440 records. The numeric values of leaf N and P stoichiometry varied significantly across families and showed diverse trends along gradients of mean annual temperature(MAT) and mean annual precipitation(MAP). The leaf N and P concentrations and N:P ratios of 62 families ranged from 6.11 to 30.30 mg g–1, 0.27 to 2.17 mg g–1, and 10.20 to 35.40, respectively. Approximately 1/3–1/2 of the families(22–35 of 62) showed a decrease in leaf N and P concentrations and N:P ratios with increasing MAT or MAP, while the remainder either did not show a significant trend or presented the opposite pattern. Family-specific leaf N^P scaling exponents did not converge to a certain empirical value, with a range of 0.307–0.991 for 54 out of 62 families which indicated a significant N^P scaling relationship. Our results for the first time revealed large variation in the family-level leaf N and P stoichiometry of global terrestrial plants and that the stoichiometric relationships for at least one-third of the families were not consistent with the global trends reported previously. The numeric values of the family-specific leaf N and P stoichiometry documented in the current study provide critical synthetic parameters for biogeographic modeling and for further studies on the physiological and ecological mechanisms underlying the nutrient use strategies of plants from different phylogenetic taxa. | Di Tian Zhengbing Yan Suhui Ma Yuehong Ding Yongkai Luo Yahan Chen Enzai Du Wenxuan Han Emoke Dalma Kovacs Haihua Shen Huifeng Hu Jens Kattge Bernhard Schmid Jingyun Fang | 2019 | Science China(Life Sciences)2019，62，8： | 7 |
| 4 | Nanoprobes for super-resolution fluorescence imaging at the nanoscale显示文摘Compared with other imaging techniques,fluorescence microscopy has become an essential tool to study cell biology due to its high compatibility with living cells.Owing to the resolution limit set by the diffraction of light,fluorescence microscopy could not resolve the nanostructures in the range of<200 nm.Recently,many techniques have been emerged to overcome the diffraction barrier,providing nanometer spatial resolution.In the course of development,the progress in fluorescent probes has helped to promote the development of the high-resolution fluorescence nanoscopy.Here,we describe the contributions of the fluorescent probes to far-field super resolution imaging,focusing on concepts of the existing super-resolution nanoscopy based on the photophysics of fluorescent nanoprobes,like photoswitching,bleaching and blinking.Fluorescent probe technology is crucial in the design and implementation of super-resolution imaging methods. | HOU ShangGuo LIANG Le DENG SuHui CHEN JianFang HUANG Qing CHENG Ya FAN ChunHai | 2014 | Science China Chemistry2014，57，1： | 4 |
| 5 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 6 | Superresolution imaging of telomeres with continuous wave stimulated emission depletion (STED) microscope显示文摘The significant role of telomeres in cells has attracted much attention since they were discovered.Fluorescence imaging is an effective method to study subcellular structures like telomeres.However,the diffraction limit of traditional optical microscope hampers further investigation on them.Recent progress on superresolution fluorescence microscopy has broken this limit.In this work,we used stimulated emission depletion(STED) microscope to observe fluorescence-labeled telomeres in interphase cell nuclei.The results showed that the size of fluorescent puncta representing telomeres under the STED microscope was much smaller than that under the confocal microscope.Two adjacent telomeres were clearly separated via STED imaging,which could hardly be discriminated by confocal microscopy due to the diffraction limit.We conclude that STED microscope is a more powerful tool that enable us to obtain detailed information about telomeres. | Shaopeng Wang Suhui Deng Xiaoqing Cai Shangguo Hou Jiajun Li Zhaoshuai Gao Jiang Li Lihua Wang Chunhai Fan | 2016 | Science China Chemistry2016，59，11： | 3 |
| 7 | Ultrasound-induced biophysical effects in controlled drug delivery显示文摘Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed. | Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang Lihong Sun Suhui Sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge | 2022 | Science China(Life Sciences)2022，65，5： | 2 |
| 8 | Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis显示文摘 | Suhui Wu Haixia Shang Lihuan Cui Zheng Zhang Yanli Zhang Ying Li Jun Wu Ren-Ke Li Jun Xie | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 9 | Sub-diffraction-limit cell imaging using a super-resolution microscope with simplified pulse synchronization显示文摘Stimulated emission depletion(STED) microscope is one of the most prominent super-resolution bio-imaging instruments, which holds great promise for ultrahigh-resolution imaging of cells. To construct a STED microscope, it is challenging to realize temporal synchronization between the excitation pulses and the depletion pulses. In this study, we present a simple and low-cost method to achieve pulse synchronization by using a condensed fluorescent dye as a depletion indicator. By using this method, almost all the confocal microscopes can be upgraded to a STED system without losing its original functions. After the pulse synchronization,our STED system achieved sub-100-nm resolution for fluorescent nanospheres and single-cell imaging. | Zhaoshuai Gao Suhui Deng Jiang Li Kun Wang Jiajun Li Lihua Wang Chunhai Fan | 2017 | Science China Chemistry2017，60，10： | 2 |
| 10 | Investigation of coal char-slag transition during oxidation: effect of temperature and re- sidual earbon显示文摘 | LI Suhui WHTITY K J | 2009 | Energy & Fuels2009，23，4： | 1 |
| 11 | Study on the DME-cytochrome b_5 and its mutants at site of F58显示文摘Phenylalanine-58 is one of the conservative residues in the hydrophobic pocket of Cyt b5, which forms aromatic stacking with the heme b. Previous study showed that both the stacking and the property of the aromatic resi-due affect hydrophobicity of the heme pocket, leading to change of protein抯 property. In order to further reveal the essence we esterify the heme propionate of Cyt b5, F58Y and F58W, and eliminate the hydrogen bond between heme propionate and Ser64 in examining the effect of hydrogen net on the p-p interaction. In this paper thermal denaturation of DME-Cyt b5 and its F58Y and F58W mutants has been stud-ied by UV-visible and CD spectra. The heme transfer reac-tions between these proteins and apo-myoglobin have been studied as well. The results demonstrate that esterification did not destroy the aromatic stacking; however, it affects the stability of the proteins due to different volumes, hydropho-bicities and hydrogen bonds forming ability of these sub-stituents. | SUHui LUJunxia WANGYunhua RENYi XIEYi HUANGZhongxian | 2004 | Chinese Science Bulletin2004，49，18： | 1 |
| 12 | Physical phenomena of char- slag transition in pulverized coal gasifieationmain 显示文摘 | LI Suhui WHITFY K J | 2012 | Fuel Processing Technology2012，95，： | 1 |
| 13 | Single frequency Nd : YAG ring laser with corner cube prism显示文摘 | Wu Keying Yang Suhui Zhao Changming | 2000 | Chinese Physics Letter2000，17，10： | 1 |
| 14 | A secure control protocol for USB mass storage devices显示文摘 | Fuw Yiyang Tzung Dawu Chiu Suhui | 2010 | IEEE Transac- tions on Consumer Electronics2010，56，4： | 1 |
| 15 | A convenient synthesis of (32OXO21, 32diaryl) propylpropanedinitrile catalyzed by KF/Al2O3显示文摘 | Daqing S Zaisheng L Suhui W | 1998 | SynthComm1998，28，40： | 1 |
| 16 | Mobile Banking Payment System显示文摘 | Fuwyi Yang Zhenwei Liu Suhui Chiu | 2011 | Journal of Wireless Mobile Networks2011，3，2： | 1 |
| 17 | The N-terminal domain of EspF induces host cell apoptosis after infection with enterohaemorrhagic Escherichia coli O157:H7显示文摘 | ZHAO Suhui ZHOU Ying WANG Chunhui | 2013 | PLoS One2013，8，55： | 1 |
| 18 | SEM study of a polystyrene/clay nanocomposite 显示文摘 | Fan Jiaqi Liu Suhui Chen Guangming | 2002 | J Appl Polym Sci2002，83，1： | 1 |
| 19 | 早期宫颈癌(Ⅰb-Ⅱa期)预后相关因素的回顾性分析(英文)显示文摘Objective: To estimate the impact of parametrial infiltration and lymph node metastasis on clinical outcome in women with early-stage cervical cancer following radical hysterectomy and pelvic lymphadenectomy. Methods: Clinical records and pathologic slides of 532 patients with early-stage cervical cancer (330 Ib and 202 IIa) treated with radical hyster- ectomy and pelvic lymphadenectomy were reviewed. The study group comprised 520 patients with squamous cell carcinoma and 12 patients with adenocarcinoma of the cervix. Median follow-up time was 67 months. The association among the various histopathologic predictors of outcome was determined with analysis. The influence of the predictors on outcome was examined with log rank survival methods and the Cox regression model. Results: FIGO stage, histologic type, tumor size, depth of invasion, parametrial infiltration, lymph node metastasis, and remote metastasis were identified as significantly biologically relevant and therefore were included as candidate predictors in multivariate analysis. In particular, parametrial infiltration and lymph node metastasis were found to be simultaneous predictors of death on multivariate analysis (P < 0.05). After controlling for these two factors, the other variables considered were not statistically significant up to a two-way interaction. Conclusion: Presence of parametrial infiltration and/or lymph node metastasis in women with early-stage cervical cancer is an independent poor prognostic factor. In addition, the relatively poor survival of women with more than one lymph nodes identified with cancer cells. | Hongbo Wang Suhui Wu Zehua Wang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，12： | 1 |
| 20 | Demonstration of thermal modulation using nanoscale and microscale structures for ultralarge pixel array photothermal transducers显示文摘Large-pixel-array infrared emitters are attractive in the applications of infrared imaging and detection.However,the array scale has been restricted in traditional technologies.Here,we demonstrated a light-driven photothermal transduction approach for an ultralarge pixel array infrared emitter.A metal-black coating with nanoporous structures and a silicon(Si)layer with microgap structures were proposed to manage the thermal input and output issues.The effects of the nanoscale structures in the black coating and microscale structures in the Si layer were investigated.Remarkable thermal modulation could be obtained by adjusting the nanoscale and microscale structures.The measured stationary and transient results of the fabricated photothermal transducers agreed well with the simulated results.From the input view,due to its wide spectrum and high absorption,the black coating with nanoscale structures contributed to a 5.6-fold increase in the temperature difference compared to that without the black coating.From the output view,the microgap structures in the Si layer eliminated the in-plane thermal crosstalk.The temperature difference was increased by 340%by modulating the out-of-plane microstructures.The proposed photothermal transducer had a rising time of 0.95 ms and a falling time of 0.53 ms,ensuring a fast time response.This method is compatible with low-cost and mass manufacturing and has promising potential to achieve ultralarge-array pixels beyond ten million. | Jinying Zhang Defang Li Zhuo Li Xin Wang Suhui Yang | 2021 | Microsystems & Nanoengineering2021，7，6： | 1 |
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