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| 1 | Antioxidant and anti-glycation activities correlates with phenolic composition of tropical medicinal herbs显示文摘To determine the contribution of total phenolic content(TPC) in glycation inhibitory activity of common tropical medicinal food and spices with potential antioxidative properties. Methods:In vitro glucose-bovine serum albumin(BSA) assay was used.Ethanolic extracts of ten common household condiments/herbs(Allium sativum.Zingiber officinale.Thymus rulgaris, Petroselinum crispum,Murraya koenigii Spreng,Mentha piperita L.,Curcuma longa L.,Allium cepa L.,Allium fistulosum and Coriandrum sativum L.) were evaluated for antinxidative activity by 2,2-diphenyl-2-picrylhydrazyl(DPPH),and ferric reducing antioxidant power(FRAP) and the TPC.flavonoid and tannins content were determined.Results:Findings showed good correlation between TPC/DPPH(r= 0.8).TPC/FRAP(r= 0.8).TPC/Anti-glycation(r=0.9).DPPH/Anti-glycation (r= 0.6),FRAP/Anti-glycation(r = 0.9),Flavonoid/Anti-glycation(r=0.7) and Tannina/Antiglycation (r = 0.8) and relatively fair correlation for TPC/Flavonoids(r = 0.5) and TPC/Tannina(r = 0.5).Results imply that these plants are potential sources of natural antioxidants which have free radical scavenging activity and might be used for reducing oxidative stress.Conclusions:The positive glycation inhibitory and antioxidative activities of these tropical herbs suggest a possible role in targeting ageing,diabetic complications and oxidative stress related diseases. | JS Ramkissoon MF Mahomoodally N Ahmed AH Subratty | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，7： | 6 |
| 2 | Bitter melon: an exotic vegetable with medicinal values显示文摘 | A.H. Subratty A. Gurib-Fakim F. Mahomoodally | 2005 | Nutrition & Food Science2005，，3： | 3 |
| 3 | Bitter melon: an exotic vegetation with medicinal values显示文摘 | Subratty A H Gurib-Fakim A Mahomoodally F | 2005 | Nutrition and Food Science2005，，3： | 1 |
| 4 | Role of circulating inflammatory cytokines in patients during an acute attack of bronchial asthma显示文摘 | Subratty A H Hooloman N K | 2013 | Indian J Chest Dis Allied Sei2013，40，1： | 1 |
| 5 | Stimulatory effects of Antidesma madagascariense on D-glucose,L-tyrosine,fluid and electrolyte transport across rat everted intestine,comparable to insulin action in vitro显示文摘 | Mahomoodally MF Fakim AG Subratty AH | 2006 | Br J Biomed Sci2006，63，1： | 1 |
| 6 | Bitter melon:an exotic vegetable with medicinal values显示文摘 | SUBRATTY A H GURIB-FAKIM A MAHOMOODALLY F | 2005 | Nutrition and Food Sci- ence2005，35，3： | 1 |
| 7 | Bitter melon: anexotie vegetable with medicinal values 显示文摘 | Subratty A H Gurib - Fakim A Mahomoodally F | 2005 | Nutrition and FoodScience2005，35，34： | 1 |
| 8 | Phar- macological properties of seven medicinal plants of the Rubiaceae from Mauritius 显示文摘 | Pedersen O Gurib - Fakim A Subratty H | 1999 | Pharmaceutical Biology1999，37，3： | 1 |
| 9 | Bitter melon: an exotic vegetable with medicinal values显示文摘 | Subratty A H Gurib-Fakim A Mahomoodally F | 2005 | Nutrition and Food Science2005，3534，： | 1 |
| 10 | Bitter melon: an exotic vegetable with medicinal values显示文摘 | Subratty A H Gurib-Fakim A Mahomoodally F | 2005 | Nutrition and Food Science2005，35，3： | 1 |
| 11 | Does TAME induced contraction involve an endothelium dependent nitric oxide-cyclic GMP mediated pathway?显示文摘 | Subratty AH Hossany R | 1999 | Indian J Exp Biol1999，37，4： | 1 |
| 12 | Screening for anti-infective properties of several medicinal plants of the Mauritians flora显示文摘 | Rangasamy O Raoelison G Rakotoniriana F E Cheuk K Urverg.Ratsimamanga S Quetin-Leclercq J Gurib-Fakim A Subratty A H | | 0，，02： | 1 |
| 13 | Experimental evidence for in vitro fluid transport in the presence of a traditional medicinal fruit extract across rat everted intestinal sacs显示文摘 | Mahomoodally MF Gurib-Fakim A Subratty AH | 2005 | Fundam Clin Pharmacol2005，19，1： | 1 |
| 14 | Bitter melon: an exotic vegetable with medicinal values 显示文摘 | Subratty A H Gurib-Fakim A Mahomoodally F | 2005 | Nutrition and Food Science2005，35，3： | 1 |
| 15 | Momordica charantia extracts inhibit uptake of monosaccharide and amino acid across rat everted gut sacs in-vitro显示文摘 | Mahomoodally MF Fakim AG Subratty AH | 2004 | Biol Pharm Bull2004，27，2： | 1 |
| 16 | Inhibition of glucose-and fructose-mediated protein glycation by infusions and ethanolic extracts of ten culinary herbs and spices显示文摘Objective: To investigate the inhibitory activity of ten culinary herbs and spices namely on glucose-mediated glycation(GMG) and fructose-mediated glycation(FMG) of bovine serum albumin.Methods: Fluorescence was used as an index of albumin glycation using glucose and fructose as substrates in the presence of infusions and ethanolic extracts of ten culinary herbs and spices. Antioxidant activity of the extracts was evaluated using reducing power,metal ion chelating and superoxide radical scavenging assays. Phytochemicals profile was analysed using 13 standard methods.Results: FMG was found to be significantly higher than GMG(95 and 84 AU,respectively; P < 0.05). Infusions and ethanolic extracts showed significant(P < 0.05)inhibitory activity on both GMG and FMG when compared to appropriate controls. No significant difference(P > 0.05) was found in the percentage glycation inhibitory activity of infusions compared to ethanolic extracts. The mean percentage inhibitory activity of the extracts for GMG(45.9%) and for FMG(45.1%) was not significantly different(P > 0.05). Qualitative phytochemical analysis showed the presence of alkaloids, flavonoids, tannins, terpenoids, anthraquinones, steroids, reducing sugars, proteins, phenols,saponins, phlobatannins, and cardiac glycosides.Conclusions: The higher rate of fluorescence generation by fructation suggests that glycation by fructose deserves much attention as a glycating agent. Data herein showed that the extracts inhibited GMG and FMG. Thus, these edible plants could be a natural source of antioxidants and anti-glycation agent for preventing advanced glycation endproducts-mediated complications. | Jugjeet Singh Ramkissoon Mohamad Fawzi Mahomoodally Anwar Hussein Subratty Nessar Ahmed | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 0 |
| 17 | In vitro modulation of oxidative burst via release of reactive oxygen species from immune cells by extracts of selected tropical medicinal herbs and food plants显示文摘Objective:To evaluate in vitro immunomodulating properties and potential cytotoxicity of six tropical medicinal herbs and food plants namely Antidesma madagascariense(Euphorbiaceae) (AM),Erylhroxylum macrocarpum(Erythroxylaceae)(EM),Faujasiopsis flexuosa(Asteraceae) (FF),Pittosporum senacia(Pittosporaceae)(PS),Momordica charantia(Cucurbitaceae)(MC) and Orimum tenuiflorum(Lamiaceae)(Of).Methods:Initially,the crude water and methanol extracts were probed for their capacity to trigger immune cells’ NADPH oxidase and MPO-dependent activities as measured by lucigenin- and luminol-amplified chemiluminescence,respectively; as compared to receptor-dependent(serum opsonised zymosan- OPZ) or receptor-independent phorbol myristerate acetate(PMA).Results:Preliminary screening on whole human blood oxidative buret activity showed significant and concentration-dependent immunomodulating properties of three plants AM,FF and OT.Further investigations of the fractions on isolated human polymorphonuclear cells(PMNs) and mice monocytes using two different pathways for activation of phagocytic oxidative burst showed that ethyl acetate fraction was the most potent extract. None of the active samples had cell-death effects on human PMNs,under the assay conditions as determined by the trypan-blue exclusion assay.Since PMA and OPZ NADPH oxidase complex is activated via different transduction pathways,these results suggest that AM,FF and OT does not affect a specific transductional pathway,but rather directly inhibit a final common biochemical target such as the NADPH oxidase enzyme and/or scavenges ROS.Conclusions:Our findings suggest that some of these plants extracts/fractions were able to modulate significantly immune response of phagocytes and monocytes at different steps,emphasizing their potential as a source of new natural alternative immunomodulatory agents. | Fawzi Mahomoodally Ahmed Mesaik M Iqbal Choudhary Anwar H Subratty Gurib-Fakim | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，6： | 0 |
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