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| 1 | Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease显示文摘Background:Alzheimer’s disease(AD)is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens.Intensive efforts have been made to find effective and safe treatment against AD.Salidroside(Sal)is the main effective component of Rhodiola rosea L.,which has several pharmacological activities.The objective of this study was to investigate the efficacy of Sal in the treatment of AD transgenic Drosophila and the associated mechanisms.Methods:We used tau transgenic Drosophila line(TAU)in which tau protein is expressed in the central nervous system and eyes by the Gal4/UAS system.After feeding flies with Sal,the lifespan and locomotor activity were recorded.We further examined the appearance of vacuoles in the mushroom body using immunohistochemistry,and detected the levels of total glycogen synthase kinase 3β(t-GSK-3β),phosphorylated GSK-3β(p-GSK-3β),t-tau and p-tau in the brain by western blot analysis.Results:Our results showed that the longevity was improved in salidroside-fed Drosophila groups as well as the locomotor activity.We also observed less vacuoles in the mushroom body,upregulated level of p-GSK-3βand downregulated p-tau following Sal treatment.Conclusion:Our data presented the evidence that Sal was capable of reducing the neurodegeneration in tau transgenic Drosophila and inhibiting neuronal loss.The neuroprotective effects of Sal were associated with its up-regulation of the p-GSK-3βand down-regulation of the p-tau. | Bei Zhang Qiongqiong Li Xingkun Chu Suya Sun Shengdi Chen | 2016 | Translational Neurodegeneration2016，5，1： | 14 |
| 2 | A metabolomic approach to lung cancer显示文摘 | Suya Hori Shin Nishiumi Kazuyuki Kobayashi Masakazu Shinohara Yukihisa Hatakeyama Yoshikazu Kotani Naoya Hatano Yoshimasa Maniwa Wataru Nishio Takeshi Bamba Eiichiro Fukusaki Takeshi Azuma Tadaomi Takenawa Yoshihiro Nishimura Masaru Yoshida | 2011 | Lung Cancer2011，，2： | 2 |
| 3 | Experimental determination of bubble size distributions in laboratory scale sieve tray with mesh显示文摘 | WANG Weiwen LI Suya LI Jianlong | 2012 | Industrial&Engineering Chemistry Research2012，51，20： | 1 |
| 4 | A robust hybrid tracking system for outdoor augmented reality显示文摘 | JIANG B NEUMAN U SUYA Y | 2004 | Virtual Reality2004，27，3： | 1 |
| 5 | Emissions properties of Ho3+:5I7→5I8 transition sensitized by Er^3+ and Yb^3+ in fluorophosphate glasses 显示文摘 | YI Lixia WANG Meng FENG Suya | 2009 | Opt Mater2009，31，11： | 1 |
| 6 | Struc- ture, hardness and thermal stability of TiA1N and nano- layered TiA1N/CrN muhilayer films 显示文摘 | Barshilia H C Suya Prakash M Jain A | 2005 | Vacuum2005，77，2： | 1 |
| 7 | Effect of B_2O_3 Additives on the Sintering and Dielectric Behaviors of CaMgSi_2O_6 Ceramics显示文摘The effects of B2O3 addition, as a sintering agent, on the sintering behavior, microstructure and dielectric properties of CaMgSi2O6 ceramic have been investigated. The CaO-MgO-B2O3-SiO2 glassy phase came forth by adding B2O3 into CaO-MgO-SiO2 ceramic powders, and it was advantageous to lower the synthesis temperature of CaMgSi2O6 crystalline phase. Moreover, the emergence of CaO-MgO-B2O3-SiO2 glass phase could effectively lower the sintering temperature of CaMgSi2O6 ceramic and promote the CaMgSi2O6 grains growing. With 6 wt pct B2O3 addition, the densification temperature of CaMgSi2O6 ceramic could be effectively reduced from 1300 to 1100℃, and the dielectric constant (εr) and dielectric loss (tanδ) were: εr=7.61 and tanδ=7.4×10-4 (1 MHz). | Huanping Wang Shiqing Xu Suya Zhai Degang Deng Haidong Ju | 2010 | Journal of Materials Science & Technology2010，26，4： | 1 |
| 8 | Self-repair of or- dered pattern of nanometer dimensions based on self-com- pensation properties of anodic porous alumina显示文摘 | Masuda H Yot Suya M Asano M | 2001 | Appl Phys Lett2001，78，6： | 1 |
| 9 | Different noted, immunohisto- chemical staining on experimental early diagnosis of acute myocar- dial ischemia 显示文摘 | Shao - tongxian Zhang - suya | 2005 | Shanxi medical journal2005，34，4： | 1 |
| 10 | Augmented Virtual Environments (AVE):Dynamic Fusion of Imagery and 3D Models显示文摘 | Ulrich N Suya Y and Jinhui H | 2003 | Proceeding of the IEEE Virtual Reality2003，，： | 1 |
| 11 | High performance liquid chromatographytandem mass spectrometry for the analysis of bile acid profiles in serum of women with intrahepatic cholestasis of pregnancy显示文摘 | LianY Suya L Meng W | 2007 | Journal of Chromatography B2007，860，： | 1 |
| 12 | Distinct tissue expression profiles of chicken Lpin1 - α / β isoforms and the effect of the variation on muscle fiber traits显示文摘 | Suya Li Wen Chen Xiangtao Kang Ruili Han Guirong Sun Yanqun Huang | 2012 | Gene2012，，： | 1 |
| 13 | Real-Tirae Object Tracking for Augmented Reality Combining Graph Cuts and Optical Flow显示文摘 | Jonathan Mooser’Suya You Ulrich Neumann | 2007 | 6th IEEE and ACM International Symposium on Mixed and Augmented Reality2007，，： | 1 |
| 14 | Effects of Mycophenolate Mofetil Combined with Corticosteroids for Induction Therapy of Microscopic Polyangiitis显示文摘 | Han Fei Liu Guangyi Zhang Xiaohui Li Xiayu He Qiang He Xuelin Li Qun Wang Suya Wang Huiping Chen Jianghua | 2011 | EN2011，，2： | 1 |
| 15 | Preparation of Hydrophobic Drugs Cyclodextrin Complex by Lyophilization Monophase Solution显示文摘 | Zhixuan Wang Yingjie Deng Suya Sun Xiaopeng Zhang | 2006 | Drug Development and Industrial Pharmacy2006，，1： | 1 |
| 16 | Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice显示文摘Background Neuropsychiatric symptoms(NPS)such as depression,anxiety,apathy,and irritability occur in prodromal phases of clinical Alzheimer’s disease(AD),which might be an increased risk for later developing AD.Here we treated young APP/PS1 AD model mice prophylactically with serotonin-selective re-uptake inhibitor(SSRI)paroxetine and investigated the protective role of anti-depressant agent in emotional abnormalities and cognitive defects during disease progress.Methods To investigate the protective role of paroxetine in emotional abnormalities and cognitive defects during disease progress,we performed emotional behaviors of 3 months old APP/PS1 mouse following oral administration of paroxetine prophylactically starting at 1 month of age.Next,we tested the cognitive,biochemical and pathological,effects of long term administration of paroxetine at 6 months old.Results Our results showed that AD mice displayed emotional dysfunction in the early stage.Prophylactic administration of paroxetine ameliorated the initial emotional abnormalities and preserved the eventual memory function in AD mice.Conclusion Our data indicate that prophylactic administration of paroxetine ameliorates the emotional dysfunction and memory deficit in AD mice.These neuroprotective effects are attributable to functional restoration of glutamate receptor(GluN2A)in AD mice. | Peng-Hui Ai Si Chen Xian-Dong Liu Xiao-Na Zhu Yuan-Bo Pan Dong-Fu Feng Shengdi Chen Nan-Jie Xu Suya Sun | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 17 | Quantification of components in overlapping peaks from capillary electrophoresis by using continues wavelet transform method 显示文摘 | Long Jiaoa Suya Gaoa Fang Zhangb | 2008 | Talanta2008，75，4： | 1 |
| 18 | Aripiprazoletreatmentofrisperidone-inducedhyperprolactinemia显示文摘 | ChenJX SuYA WangSL etal | 2009 | JClinPsychiatry2009，70，7： | 1 |
| 19 | Augmented virtual environments(AVE): Dynamic Fusion of Imagery and 3D Models显示文摘 | Ulrich N Suya Y and Jinhui H | 2003 | Proceeding of the IEEE Virtual Reality2003，，： | 1 |
| 20 | Intelligent diagnosis of the solder bumps defects using fuzzy C-means algorithm with the weighted coefficients显示文摘Solder bump technology has been widely used in electronic packaging. With the development of solder bumps towards higher density and finer pitch, it is more difficult to inspect the defects of solder bumps as they are hidden in the package. A nondestructive method using the transient active thermography has been proposed to inspect the defects of a solder bump, and we aim at developing an intelligent diagnosis system to eliminate the influence of emissivity unevenness and non-uniform heating on defects recognition in active infrared testing. An improved fuzzy c-means(FCM) algorithm based on the entropy weights is investigated in this paper. The captured thermograms are preprocessed to enhance the thermal contrast between the defective and good bumps. Hot spots corresponding to 16 solder bumps are segmented from the thermal images. The statistical features are calculated and selected appropriately to characterize the status of solder bumps in FCM clustering. The missing bump is identified in the FCM result, which is also validated by the principle component analysis. The intelligent diagnosis system using FCM algorithm with the entropy weights is effective for defects recognition in electronic packages. | LU XiangNing SHI TieLin WANG SuYa LI Li Yi SU Lei LIAO GuangLan | 2015 | Science China(Technological Sciences)2015，58，10： | 1 |
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