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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 3 | Phycobilin : cystein-84 biliprotein lyase,a near universal lyase for cysteine-84-binding sites in cyanobacterial phycobiliproteins 显示文摘 | Zhao K H Su P Tu J M | 2007 | Proc Natl Acad Sci USA2007，104，14： | 1 |
| 4 | Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis 显示文摘 | Sauane M Su Z Z Gupta P | 2008 | Proc Natl Acad Sci U S A2008，105，： | 1 |
| 5 | A Resonant Accel- erometer with Two-Stage Micro-Leverage Mechanisms Fabricated by SOI-MEMS Technology 显示文摘 | Susan X P Su Henry S Yang Alice M Agogino | 2005 | IEEE Sensors Journal2005，5，6： | 1 |
| 6 | Research on aging precipitation in a Cu-Cr-Zr-Mg alloy显示文摘 | Su J H Dong Q M Liu P | 2005 | Mater Sci Eng2005，392，： | 1 |
| 7 | Flow of ductile iron through ceramic filters and the effects on the dross and fatigue properties显示文摘 | Khan P R Su W M | 1987 | AFS Transactions1987，，95： | 1 |
| 8 | New briaranes fromthe octocorals Briareum excavatum (Briareidae) andJunceella fragilis ( Ellisellidae) 显示文摘 | Sung P J Lin M R Su Y D | 2008 | Tetrahedron2008，64，11： | 1 |
| 9 | Sliding mode control with varying boundary layers for an electro-hydraulic position servo system显示文摘 | Chen H M Ren J C Su J P | | 0，，1： | 1 |
| 10 | An observation study of the HONO-NO2coupling at an urban site in Guangzhou City,South China显示文摘 | Qin M Xie P H Su H | 2009 | 43(36):5731-57422009，43，36： | 1 |
| 11 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | Excitons and nonlinear optical spectra in conjugated polymers显示文摘 | Abe S Schreiber M Su W P | 1992 | Phys Rev B1992，45，16： | 1 |
| 13 | The GDPAL region of the pre-S1 envelope protein is important for morphogenesis of woodchuck hepatitis virus显示文摘 | Yu M Emerson SU Cote P | 1998 | Hepatology1998，27，5： | 1 |
| 14 | Actuat显示文摘 | Wei B Y Hsu M C Su P G Lin H M Wu R J Lai H J Sensor | 2004 | B2004，101，： | 1 |
| 15 | Production of monoclonal antibodies using recombinant baculovirus displaying gp64-fusion proteins 显示文摘 | Lindley K M Su J L Hodges P K | 2000 | J Immunol Methods2000，234，12： | 1 |
| 16 | The effect of varicoc- electomy on serum testosteroneleve|s in infertile men with varico- celes显示文摘 | SU L M GOLDSTEIN M SCHLEGEL P N | 1995 | JUrol1995，154，5： | 1 |
| 17 | Purification of single walled carbon nanotubes synthesized by the catalytic decomposition of hydrocarbons显示文摘 | F LI H M CHENG Y T XING P H TAN G SU | 2000 | Carbon2000，38，： | 1 |
| 18 | An interactive method for dynamicintuitionistic fuzzy multi-attribute group decision making显示文摘 | Su Z X Chen M Y Xia G P | 2011 | ExpertSystems with Applications2011，38，15： | 1 |
| 19 | Changes in glucocorticoid and mineralcocrticoid receptors of liver and kidney cytosols after pathological stress and its regulation in rats显示文摘 | Liu D H Su Y P Cheng T M | 2002 | Critical Care Medicine2002，30，3： | 1 |
| 20 | Study on metal ion affinities to oxygen delignified hardwood kraft pulp by a column chromatographic method 显示文摘 | Sodo M Su P Granholm K | 2007 | Nord Pulp & Paper Research Journal2007，22，4： | 1 |
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