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| 1 | Current global trends in the incidence of pediatric-onset inflammatory bowel disease显示文摘AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts. | Josef Sykora Renta Pomahacov Marcela Kreslová Dominika Cvalínová Premysl Stych Jan Schwarz | 2018 | World Journal of Gastroenterology2018，24，25： | 27 |
| 2 | Multinational, Placebo-Controlled, Randomized Trial of the Effects of Alendronate on Bone Density and Fracture Risk in Postmenopausal Women with Low Bone Mass: Results of the FOSIT Study显示文摘 | H. A. P. Pols D. Felsenberg D. A. Hanley J. ?tepán M. Mu?oz-Torres T. J. Wilkin G. Qin-sheng A. M. Galich K. Vandormael A. J. Yates B. Stych | 1999 | Osteoporosis International1999，，5： | 1 |
| 3 | C-peptide reduces high-glucose- induced apoptosis of endothelial cells and decreases NAD(P)H-Oxidase reactive oxygen species generation in human aortic endothelial cells显示文摘 | Cifarelli Y Geng X Styche A | 2011 | Diabetologia2011，54，10： | 1 |
| 4 | Modulation of redox bal-ance leaves murine diabetogenic THl T cells 'LAG-3-ingM behind 显示文摘 | Delmastro MM Styche AJ Trucco MM | 2012 | Diabetes2012，61，7： | 1 |
| 5 | Pyrosequencing-based strategies for improved allele typing of human leukocyte antigen loci显示文摘 | Ringquist S Styche A Rudert WA | 2007 | Methods Mol Biol2007，373，： | 1 |
| 6 | HLA class Ⅱ DRB high resolution genotyping by Pyrosequencing:comparison of group specific PCR and Pyrosequencing primers显示文摘 | Ringquist S Alexander AM Styche A | 2004 | Hum Immunol2004，65，2： | 1 |
| 7 | Evaluation of different recruitment and randomization methods in a trial of general practitioner-led interventions to increase physical activity:a randomized controlled feasibility study with factorial design显示文摘 | Fiona C Warren Kate Stych Margaret Thorogood | 2014 | Trials2014，，15： | 1 |
| 8 | C-peptide reduces highglucoseinduced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells显示文摘 | Cifarelli V Geng X Styche A | 2011 | Diabetologia2011，54，10： | 1 |
| 9 | HLA class II DRB high resolution genotyping by pyrosequencing: Comparison of group specific PCR and pyrosequencing primers 显示文摘 | Ringquist S Alexander AM Styche A | 2003 | Hum Immunol2003，65，2： | 1 |
| 10 | HLA classⅡ DRB high resolution genotyping by pyrosequencing:comparison of group specific PCR and pyrosequencing primers显示文摘 | ALEXANDER A M STYCHE A | 2004 | HumImmunol2004，65，2： | 1 |
| 11 | HLA class Ⅱ DRB high resolution genotyping by pyrosequencing:comparison of group specific PCR and pyrosequencing primers显示文摘 | RINGQUIST S ALEXANDER AM STYCHE A | 2003 | Hum immunol2003，65，2： | 1 |
| 12 | C-peptide reduces high- glucose-induced apoptosis of endothelial cells and decreases NAD(P) H-oxidase reactive oxygen species generation in hu- man aortic endothelial cells 显示文摘 | Cifarelli V Geng X Styche A | 2011 | Diabetologia2011，54，10： | 1 |
| 13 | Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and βcell regeneration in a TID model显示文摘以前,我们建立了在的一个模型自体同源的 β 的生理地足够的功能;房间在非肥胖的糖尿病患者(点头) 被恢复在由显示他们的多糖症的发作以后的老鼠 hemopoietic 怪物。这些老鼠被称为 antea 糖尿病。在当前的学习,我们探讨了 T 的角色规章(Treg ) 在调停的机制的房间在 antea 糖尿病的点头模型的 euglycemia 的恢复。在这研究产生的数据证明 Treg 房间的数字在 unmanipulated 点头鼠标被减少,与在胰腺的淋巴节点(PLN ) 检测的最深刻的缺乏。在 PLN 的 Treg 房间的损害保留与涉及他们的 trafficking 的 chemokines 的局部地损害的侧面相关,与在 SDF-1 观察的最突出的减少。autoimmunity 的改善和在 antea 糖尿病的老鼠观察的 euglycemia 的恢复在 PLN 与 Treg 房间人口的恢复被联系。这些数据显示 SDF-1/CXCR4 轴的功能和在 PLN 的 Treg 房间的保留在 diabetogenesis 并且在 autoimmunity 和 β 的改善有一个潜在的角色;在 antea 糖尿病的模型的房间新生。我们在 antea 糖尿病的老鼠模型表明了 β 的那终生的恢复;房间在 PLN 与 Treg 房间人口的正规化有强壮的关联。这发现为测试为类型 1 糖尿病(T1D ) 作为一条治疗学的途径在 PLN 支持 Treg 房间的累积的 immunomodulatory 政体提供新机会。 | Benjamin K Nti Janet L Markman Suzanne Bertera Alexis J Styche Robert J Lakomy Vladimir M Subbotin Massimo Trucco Tatiana D Zorina | 2012 | Cellular & Molecular Immunology2012，9，6： | 0 |
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