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| 1 | Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic(+3 oxidation state)methyltransferase-knockout mice显示文摘Arsenic methyltransferase(As3mt) catalyzes the conversion of inorganic arsenic(i As) to its methylated metabolites, including toxic methylarsonite(MAs~Ⅲ) and dimethylarsinite(DMAs~Ⅲ). Knockout(KO) of As3 mt was shown to reduce the capacity to methylate i As in mice. However, no data are available on the oxidation states of As species in tissues of these mice. Here, we compare the oxidation states of As species in tissues of male C57BL/6 As3mt-KO and wild-type(WT) mice exposed to arsenite(iA s~Ⅲ) in drinking water. WT mice were exposed to50 mg/L As and As3mt-KO mice that cannot tolerate 50 mg/L As were exposed to 0, 15, 20, 25 or30 mg/L As. iA s~Ⅲaccounted for 53% to 74% of total As in liver, pancreas, adipose, lung, heart, and kidney of As3mt-KO mice; tri- and pentavalent methylated arsenicals did not exceed 10% of total As. Tissues of WT mice retained iA s and methylated arsenicals: iA s~Ⅲ, MAs~Ⅲand DMAs~Ⅲ represented 55%‐68% of the total As in the liver, pancreas, and brain. High levels of methylated species, particularly MAs~Ⅲ, were found in the intestine of WT, but not As3mt-KO mice,suggesting that intestinal bacteria are not a major source of methylated As. Blood of WT mice contained significantly higher levels of As than blood of As3mt-KO mice. This study is the first to determine oxidation states of As species in tissues of As3mt-KO mice. Results will help to design studies using WT and As3mt-KO mice to examine the role of iA s methylation in adverse effects of iA s exposure. | Jenna M.Currier Christelle Douillet Zuzana Drobná Miroslav Styblo | 2016 | Journal of Environmental Sciences2016，28，11： | 8 |
| 2 | The cellular metabolism and systemic toxicity of arsenic 显示文摘 | Thomas DJ Styblo M Lin S | 2001 | Toxicol Appl Pharmacol2001，176，： | 1 |
| 3 | The cellular metabolism and systemic toxicity of arsenic 显示文摘 | Thomas D J Styblo M Lin S | 2001 | Toxicology and Applied Pharmacology2001，176，2： | 1 |
| 4 | The cellular metabolism and systemic toxicity of arsenic显示文摘 | Thomas D L Styblo M Lin S | 2001 | Toxicology and Applied Pharmacology2001，176，： | 1 |
| 5 | Differential effects of trivalent and pentavalent arsenicalson cell proliferation and cytokine secretion in normal human epidermal keratinocytes显示文摘 | Vega L Styblo M Patterson R | 2001 | Toxicol Appl Pharmaco2001，172，3： | 1 |
| 6 | Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells 显示文摘 | Styblo M Del Razo L M Vega L | 2000 | Ar- chives of Toxicology2000，74，6： | 1 |
| 7 | Methylated metabolites of arsenic trioxide are mord potent than arsehie trioxide as appoptotic but not differentiation inducers in leukemia and lymphom cells 显示文摘 | Chen G Q Zhou L Styblo M | 2003 | J Cancer Ras2003，63，8： | 1 |
| 8 | Sentinel node staging of early breast cancer using lymphoscintigraphy and the intraoperative gamma detecting probe 显示文摘 | Alazraki NP Styblo T Grant SF | 2001 | Radiol Clin North Am2001，39，5： | 1 |
| 9 | Elucidating the pathway for arsenic methylation显示文摘 | Thomas DJ Waters SB Styblo M | | 0，，03： | 1 |
| 10 | Local recurrence after skin-sparing mastectomy:tumor biology or surgical conservatism?显示文摘 | Carlson GW Styblo TM Lyles RH | 2003 | Ann Surg Oncol2003，10，2： | 1 |
| 11 | The cellular metabolism and systemic toxicity of arsenic显示文摘 | Thomas DJ Styblo M Lin S | 2001 | Toxicol Appl Pharmacol2001，176，： | 1 |
| 12 | Contacts of cases of active pulmonary tuberculosis显示文摘 | Grzybowski S Barnett GD Styblo K | 1975 | Bull Int Union Tuberc1975，50，1： | 1 |
| 13 | The role of biomethylation in toxicity and carcinogenicity of arsenic:a research update显示文摘 | Drobna z Jaspers I | 2002 | Environ Health Perspect2002，5，： | 1 |
| 14 | Metabolism of arsenic in primary cultures of human and rat hepatocytes显示文摘 | Styblo M Del Razo LM LeCluyse EL | 1999 | Chem Res Toxicol1999，12，7： | 1 |
| 15 | The cellular metabolism and systemic toxicity of arsenic 显示文摘 | ThomasDJ Styblo M Lin S | 2001 | Toxicol Appl Pharmacol2001，176，2： | 1 |
| 16 | The cellular metabolism and systemic toxicity of arsenic 显示文摘 | Thomas DJ Styblo M Lin S | 2001 | Toxicol Appl Pharmacol2001，176，2： | 1 |
| 17 | Determination of trivalent methylated arsenicals in biological matrices显示文摘 | Styblo M Callen WR | 2001 | Toxicol Appl Pharmacol2001，174，： | 1 |
| 18 | Tuberculosis in developing countries: Burden, intervention and cost 显示文摘 | Murray C J Styblo K Rouillon A | 1990 | Bull Int Union Tuberc Lung Dis1990，65，1： | 1 |
| 19 | Management algorithm and outcome evaluation of partial mastectomy defects treated using duetion or mastopexy techniques显示文摘 | Losken A Styblo TM Carlson GW et aI | 2007 | Ann Plast Surg2007，59，3： | 1 |
| 20 | The cellular metabolism and systemic toxicity of arsenic显示文摘 | Thomas DJ Styblo M Lin S | 2001 | Toxicol Appl Pharmacol2001，176，5： | 1 |
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