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| 1 | Preoperative high level of D-dimers predicts unresectability of pancreatic head cancer显示文摘AIM: To assess the value of D-dimer level in determining resectability of pancreatic cancer. METHODS: Preoperative prediction of pancreatic head cancer resectability remains inaccurate. The use of hemostatic factors may be of potential help, since D-dimers correlate with tumor stage. Single center clinical trial study comprised patients with potentially resectable pancreatic head tumor and without detectable venous thrombosis(n = 64). Resectability was defined as no evidence of nodal involvement, distant spread and no invasion of mesenteric vessels. Final decision of resectability was confirmed intraoperatively. Experienced pancreatic surgeon performed all surgeries. Following the dissection of hepatoduodenal ligament, samples of portal blood and bile were taken. Peripheral blood via central line and urine via Foley catheter were sampled. D-dimer levels were further measured.RESULTS: At laparotomy only 29(45.3%) tumors were found to be resectable. Our analysis showed higher by 57.5%(P < 0.001) mean D-dimer values in peripheral and 43.7%(P = 0.035) in portal blood of patients with unresectable pancreatic cancer. Significant differences were not observed when analyzing D-dimer levels in bile and urine. Peripheral D-dimer level correlated with pancreatic cancer resectability. When cut-off D-dimer value of 570.6 μg/L was used, the sensitivity for assessment of tumor unresectability was 82.8%. Furthermore, D-dimer level in peripheral blood of metastatic disease(n = 15) was significantly higher when compared to locally advanced(n = 20) pancreatic cancer(2470 vs 1168, P = 0.029). The area under ROC curve for this subgroup of patients was 0.87; for determination of unresectable disease when threshold of 769.8 μg/L was used, sensitivity and specificity was 86.6% and 80%, respectively.CONCLUSION: Patients with resectable pancreatic head cancer based on preoperative imaging studies and high D-dimer level may be considered unresectable due to occult hepatic metastases. These patients may benefit from diagnostic laparoscopy to avoid exploratory laparotomy. | Adam Durczynski Anna Kumor Piotr Hogendorf Dariusz Szymanski Piotr Grzelak Janusz Strzelczyk | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 2 | 拉科酰胺在癫痫持续状态中的应用--针对现有证据的系统评价显示文摘拉科酰胺(Lacosamide,LCM)的静脉制剂具有良好的耐受性和安全性,促使其在癫痫持续状态(Status Epilepticus,SE)中得到应用。本项系统评价的目的是确定和评估LCM在SE中的使用情况。在电子数据库中用联合检索方式对2008年—2016年10月的文献进行了系统检索,并使用标准化的评估表格从各项研究中将有关研究设计、方法框架、数据源、有效性和LCM引起的不良反应的信息进行提取并系统地报告。研究共评估了522次SE发作,其中包括486例成人和36例儿童及青少年发作,女性占51.7%。LCM的总体效力为57%。LCM对非惊厥性(57%,82/145)和全面痉挛性(61%,30/49,P=0.68)SE的效力相似,但对局灶运动性SE的总体有效率更高(92%,34/39,P<0.001)。而LCM在用药次序靠后时其疗效从100%下降到20%。治疗期间的主要不良反应是眩晕,视力异常,复视和共济失调。总体而言,LCM具有良好的耐受性,并且没有具临床意义的药物相互作用。现有数据表明LCM在SE中的使用是有前景的,有效率为57%。LCM的优势在于没有潜在的药物相互作用,并且在紧急情况需迅速增加剂量时可静脉使用。 | Adam Strzelczyk Johann Philipp Zollner Laurent M Willems 肖英凤 童馨 慕洁 Julie Jost Esther Paule Susanne Schubert-Bast Felix Rosenow Sebastian Bauer | 2018 | 癫痫杂志2018，4，5： | 2 |
| 3 | Ictal asystole in temporallobe epilepsy before and after pacemaker implantation 显示文摘 | Strzelczyk A Bauer S Knake S | 2008 | Epileptic Disord2008，10，： | 1 |
| 4 | Cada- veric study on static medial patellar stabilizers:the dynamiz- ing role of the vastus medialis obliquus on medial patel- lofemoral ligament显示文摘 | Panagiotopoulos E Strzelczyk P Herrmann M | 2006 | Knee Surg Sports Traumatol Arthro- sc2006，14，1： | 1 |
| 5 | The usefulness of determining the serum concentrations of vascular endothelial growth factor (VEGF) and its soluble receptor type 2 (sVEGF-2) in the differential diagnosis of adrenal incidentalomas显示文摘 | Foltyn W Strzelczyk J Marek B | 2012 | Endokrynol Pol2012，63，： | 1 |
| 6 | Cadaveric study on static medial patellar stabilizers:the dynamizing role of the vastus medialis obliquus on medial patellofemoral ligament 显示文摘 | Panagiotopoulos E Strzelczyk P Herrmann M | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，1： | 1 |
| 7 | Cadaveric study on static medial patellar stabilizers: the dynamizing role of the vastus medialis obliquus on medial patell of emoralligament显示文摘 | Panagi E Strzelczyk P Herrmann M | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，1： | 1 |
| 8 | Cadaveric study on static medial patellar stabilizers: the dynamizing role of the vastus medialis obliquus on medial patellofemoral ligament显示文摘 | Elias Panagiotopoulos Piotr Strzelczyk Martin Herrmann Giles Scuderi | 2006 | Knee Surgery Sports Traumatology Arthroscopy2006，，1： | 1 |
| 9 | Methylation of the MGMT and p16 genes in sporadic colorectal carcinoma and corresponding normal colonic mucosa显示文摘 | Krakowczyk L Strzelczyk JK Adamek B | 2008 | Med Sci Monit2008，14，10： | 1 |
| 10 | Post-anesthesia recovery after infusion of propofol with remifentanil or alfentanil or fentanyl in morbidly obese patients显示文摘 | GASZYNSKI TM STRZELCZYK JM GASZYNSKI WP | 2004 | Obes Surg2004，14，4： | 1 |
| 11 | Renal disease and hypertension in non-insulin-dependent diabetes mellitus显示文摘 | Ismail N Becker B Strzelczyk P | 1999 | Kidney Int1999，55，1： | 1 |
| 12 | Cadaveric study on static medial patellar stabilizers: the dynamizing role of the vastus medialis obliquus on medial patellofemoral ligament 显示文摘 | Panagiotopoulos E Strzelczyk P Herrmann M | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，1： | 1 |
| 13 | Cadaveric study on static medial patellar stabilizers:the dynamizing role of the vastus medialis obliquus on medial patellofemoral ligament显示文摘 | Panagiotopoulos E Strzelczyk P Herrmann M | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，1： | 1 |
| 14 | Effect of IL-lbeta,TNF-alpha and IL-4 on complement regulatory protein mRNA expression in human articular chondrocytes显示文摘 | HYC A OSIECKA -IWAN A STRZELCZYK p | 2003 | Int J Mol Med2003，11，1： | 1 |
| 15 | Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease 显示文摘 | OSADNIK T STRZELCZYK J HAWRANEK M | 2013 | BMC Cardiovasc Disord2013，10，13： | 1 |
| 16 | Gas-solid chromatographic separation of hydrogen isotopes: a comparison between two palladium bearing materials-alumina and kieselguhr显示文摘 | STRZELCZYK F LETERQ D WILHELM A M | 1998 | Journal of Chromatography A1998，822，2： | 1 |
| 17 | Prognostic factors in the operative and palliative treatment of pancreatic cancer显示文摘 | Talar-Wojnarowska R Gasiorowska A Strzelczyk J | 2003 | Neoplasma2003，50，5： | 1 |
| 18 | Production of auxins and gibberellin-like substances by mycorrhizal fungi,bacteria and actinomycetes isolated from soil and the mycorrhizosphere of pine显示文摘 | Strzelczyk E Pokojska-Burdzeij A | 1984 | Plant Soil1984，81，： | 1 |
| 19 | Gas-solid Chromatographic Separation of Hydrogen Isotopes: a Comparison Between Two Palladium Bearing Materials-alumina and Kieselguhr显示文摘 | STRZELCZYK F LETERQ D WILHELM AM | 1998 | J Chromatogr:A1998，822，： | 1 |
| 20 | Gastric bypass surgery in severely obese type 1 diabetic pa- tients显示文摘 | Czupryniak L Strzelczyk J Cypryk K | 2004 | Diabetes Care2004，27，： | 1 |
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