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| 1 | BH3-only proteins target BCL-xL/MCL-1,not BAX/BAK,to initiate apoptosis显示文摘It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins(BID,BIM,etc.)directly engage and allosterically activate effector proteins BAX/BAK.Here,through reconstitution of cells lacking all eight pro-apoptotic BH3-only proteins,we demonstrate that all BH3-only proteins primarily target the anti-apoptotic BCL-2 proteins BCL-xL/MCL-1,whose simultaneous suppression enables membrane-mediated spontaneous activation of BAX/BAK.BH3-only proteins*apoptotic activities correlate with affinities for BCL-xL/MCL1 instead of abilities to directly activate BAX/BAK.Further,BID and BIM do not distinguish BAX from BAK or accelerate BAX/BAK activation following inactivation of BCL-xL/MCL-1.Remarkably,death ligandinduced apoptosis in cells lacking BH3-only proteins and MCL-1 is fully restored by BID mutants capable of neutralizing BCL-xL,but not direct activation of BAX/BAK.Taken together,our findings provide a'Membrane-mediated Permissive'model,in which the BH3-only proteins only indirectly activate BAX/BAK by neutralizing the anti-apoptotic BCL-2 proteins,and thus allowing BAX/BAK to undergo unimpeded,spontaneous activation in the mitochondrial outer membrane milieu,leading to apoptosis initiation. | Kai Huang Katelyn L.O'Neill Jian Li Wei Zhou Na Han Xiaming Pang Wei Wu Lucas Struble Gloria Borgstahl Zhaorui Liu Liqiana Zhang Xu Luo | 2019 | Cell Research2019，29，11： | 16 |
| 2 | Estradiol regulation of astro- glia and apolipoprotein E:an important role in neuronal regenera- tion显示文摘 | Struble RG Nathan BP Cady C | 2007 | Exp Geronto12007，42，12： | 1 |
| 3 | Synthesis of an N-mesityl substituted chiral imidazolium salt for NHC-catalyzed reactions 显示文摘 | Struble J R Kaeobamrung J Bode J W | 2008 | Org Lett2008，10，5： | 1 |
| 4 | Acute coronary syndromes in older adults : a review of literature显示文摘 | Gillis NK Arslanian-Engoren C Struble LM | 2014 | J Emerg Nuts2014，40，3： | 1 |
| 5 | Mitochondrial respira tory inhibition and oxidative stress elevate beta secretase (BACE- 1) proteins and activity in vivo in the rat retina 显示文摘 | Xiong K Clough R W Struble R G | 2007 | Exp Brain Res2007，181，3： | 1 |
| 6 | Selective analysis of cell-free DNA in maternal blood for evaluation of fetal trisomy显示文摘 | Sparks A B Wang E T Struble C A | 2012 | Prenatal Diagnosis2012，32，1： | 1 |
| 7 | Acute Coronary Syndromes in Older Adults: A Review of Literature显示文摘 | Nicole K. Gillis Cynthia Arslanian-Engoren Laura M. Struble | 2014 | Journal of Emergency Nursing2014，，3： | 1 |
| 8 | Structural investigation of alkali silicate gels显示文摘 | HOU X KIRKPATRICK R J STRUBLE L J | 2005 | Journal of the America Ceramic Society2005，，88： | 1 |
| 9 | Human gene copy number spectra analysis in congenital heart malformations显示文摘 | Tomita-Mitchell A Mahnke DK Struble CA | 2012 | Physiol Genomics2012，44，： | 1 |
| 10 | Evidence for a symmetrical fluoronium ion in solution 显示文摘 | Struble M D Scerba M T Siegler M Lectka T | 2013 | Science2013，340，6128： | 1 |
| 11 | Formation of ASR gel and the roles of C-S-H and portlandite显示文摘 | HOU X STRUBLE L J KIRKPATRICK R J | 2004 | Cement and Concrete Research2004，，34： | 1 |
| 12 | Olfactory function in apoE knockout mice显示文摘 | Nathan B P Yost J Litherland M T Struble R G Switzer P V | 2004 | Behav Brain Res2004，150，12： | 1 |
| 13 | Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis 显示文摘 | Kuhar DT Henderson DK Struble KA | 2013 | Infect Control Hosp Epidemiol2013，34，9： | 1 |
| 14 | Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesions显示文摘 | Struble RG Beckman SL Fesser E | 2001 | Chem Senses2001，26，7： | 1 |
| 15 | Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma显示文摘 | Wang E Batey A Struble C | 2013 | Prenat Diagn2013，33，7： | 1 |
| 16 | Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and activity in vivo in the rat retina显示文摘 | Kun Xiong Huaibin Cai Xue-Gang Luo Robert G. Struble Richard W. Clough Xiao-Xin Yan | 2007 | Experimental Brain Research2007，，3： | 1 |
| 17 | Viscoelastic of Portland Cement Paste as a Function of Concentration 显示文摘 | STRUBLE L J SUN G K | 1995 | Advanced Cement Based Materials1995，2，2： | 1 |
| 18 | Autonomous driving in urban environments: Boss and the urban challenge 显示文摘 | URMSON C ANHALT J BAGNELL D BAKER C BITTNER R CLARK M N DOLAN J DUGGINS D GALATALI T GEYER C GITTLEMAN M HARBAUGH S HEBERT M HOWARD T M KOLSKI S KELLY A LIKHACHEV M MCNAUGHTON M MILLER N PETERSON K PILNICK B RAJKUMAR R RYBSKI P SALESKY B SEO Y W SINGH S SNIDER J STENTZ A WHITTAKER W WOLKOWICKI Z Z1GLAR J BAE H BROWN T DEMITRISH D LITKOUHI B NICKOLAOU J SADEKAR V ZHANG Wen-de STRUBLE J TAYLOR M DARMS M FERGUSON D | 2008 | Journal of Field Robotics2008，25，8： | 1 |
| 19 | Leveraging Java Applets:Toward Collaboration Transparency in Java显示文摘 | Struble Craig A Shaffer Clifford A | 1997 | IEEE Internet Computing1997，，1： | 1 |
| 20 | Intracranial hemor- rhage and liver-associated deaths associated with tipranavir/riton- avir: review of cases from the FDA's Adverse Event Reporting Sys- tem显示文摘 | Chan-Tack KM Struble KA Birnkrant DB | 2008 | AIDS Patient Care STDS2008，22，11： | 1 |
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