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| 1 | 影响体胚发生途径香蕉(Musa spp.,AAB Group)植株再生的因素显示文摘香蕉品种‘Agbagaba’和‘Orishele’的胚性细胞悬浮系(ECS)在液体培养基中分别预培养1和2周后,将其接种在RD1和M3培养基上,于光照或黑暗条件下进行体胚的再生。从沉积细胞体积(SCV) 为1 mL(1 mL SCV)的ECS获得的再生体胚数量因预培养时间、再生培养基的种类及培养条件的不同而异。植株的再生率及从1 mL SCV的ECS获得的再生植株数量也受上述体胚再生条件的间接影响。 | 徐春香 Bart PANIS Hannelore STROSSE Rony SWENNEN 李华平 肖火根 范怀忠 | 2004 | 植物生理学通讯2004，40，3： | 6 |
| 2 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 3 | Diapause induction in Daphnia requires two stimuli显示文摘 | STROSS P M HILL J C | 1965 | Science1965，150，： | 1 |
| 4 | Photoperiod control of winter diapause in the freshwater crustacean, Daphnia显示文摘 | STROSS P M HILL J C | 1968 | Biological Bulletin1968，134，： | 1 |
| 5 | Foxp3 ~ regulatory T cells protect the liver from immune damage and compro- mise virus control during acute, experimental hepatitis B virus infec- tion显示文摘 | Leonhard Stross Johannes Gunther Georg Gasteiger | 2012 | Hepatology2012，56，3： | 1 |
| 6 | Bottlenecks in the generation and maintenance of morphogenic banana cell suspensions and plant regen- emtionviasomatic embryogenesis therefrom显示文摘 | SCHOOFS H PANIS B STROSSE H | 1999 | Info Musa1999，8，2： | 1 |
| 7 | Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute, experimental hepatitis B virus infection 显示文摘 | Stross L Gtinther J Gasteiger G | 2012 | Hepatology2012，，： | 1 |
| 8 | Photoperiod control of winter diapause in the fresh -water crustacean Daphnia显示文摘 | | 1968 | B iol Bull Mar boil Lab Woods Hole1968，134，1： | 1 |
| 9 | Diapause induction in Daphnia requires two stimuli显示文摘 | Hill J C | 1965 | Science1965，150，3702： | 1 |
| 10 | Adventitious shoot formation is not inherent to micropropagation of banana as it is in maize显示文摘 | Strosse H Andre E S0~gi L | 2008 | Plant Cell Tiss Org Cult2008，95，： | 1 |
| 11 | Maintaining competency in advanced cardiac life support skills显示文摘 | STROSS J K | 1983 | JAMA1983，249，24： | 1 |
| 12 | Light and temperature requirements for diapause development and release in Daphnia显示文摘 | STROSS R G | 1966 | Ecology1966，47，： | 1 |
| 13 | Sucrose preculture to simplify cryopreservation of banana meristem cultures 显示文摘 | PANIS B STROSSE H HENDE S V D SWENNEN R | 2002 | Cryo-Letters2002，23，： | 1 |
| 14 | Short‐term feedback regulation of bile salt uptake by bile salts in rodent liver显示文摘 | Stefanie Mühlfeld Olga Domanova Thomas Berlage Claudia Stross Angelika Helmer Verena Keitel Dieter H?ussinger Ralf Kubitz | 2012 | Hepatology2012，，6： | 1 |
| 15 | Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute,experimental hepatitis B virus infection显示文摘 | Stross L Gunther J Gasteiger G | 2012 | Hepatology2012，56，： | 1 |
| 16 | The tyrosine 974 within the LIF-R-chain of the gpl30/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling 显示文摘 | Clahsen T Lehmann U Stross C | 2005 | Cell Signal2005，17，5： | 1 |
| 17 | Nutrient uptake kinetics in phytoplankton: a basis for niche separation 显示文摘 | Stross R G Pemriek S M | 1974 | J Hycol1974，10，2： | 1 |
| 18 | Light and temperature requirements for diapause development and release in Daphnia显示文摘 | STROSS R G | 1966 | Ecology1966，47，3： | 1 |
| 19 | Bottlenecks in the generation and maintenance of morphogenic banana cell suspensions and plant regeneration via somatic embryogenesis therefrom显示文摘 | SCHOOFS H PANIS B STROSSE H MAYO A LOPEZ J ROUX N DOLEZEL SWENNEN R | 1999 | InfoMusa1999，8，2： | 1 |
| 20 | Bottlenecks in the generation and maintenance of morphogenic banana cell suspensions and plant regeneration via somatic embryogenesis therefrom 显示文摘 | SCHOOFS H PANIS B STROSSE H | 1999 | InfoMusa1999，8，2： | 1 |
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