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| 1 | Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study显示文摘AIM To evaluate the ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize the intestinal environment of healthy subjects and modify the gut microbiota composition.METHODS Twenty healthy Italian volunteers, eight males and twelve females, participated in the study. Ten subjects took a sachet containing 4 × 109 colony-forming units(CFU) of Bifidobacterium longum BB536 and 109 CFU of Lactobacillus rhamnosus HN001, 30 min before breakfast(pre-prandial administration), while ten subjects took a sachet of probiotic product 30 min after breakfast(post-prandial administration). The ability ofLactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize human gut microbiota was assessed by means of quantitative real-time PCR, while changes in gut microbiota composition were detected by using Ion Torrent Personal Genome Machine.RESULTS Immediately after 1-mo of probiotic administration, B. longum BB536 and L. rhamnosus HN001 load was increased in the majority of subjects in both preprandial and post-prandial groups. This increase was found also 1 mo after the end of probiotic oral intake in both groups, if compared to samples collected before probiotic consumption. At phyla level a significant decrease in Firmicutes abundance was detected immediately after 1-mo of B. longum BB536 and L. rhamnosus HN001 oral intake. This reduction persisted up to 1 mo after the end of probiotic oral intake together with a significant decrease of Proteobacteria abundance if compared to samples collected before probiotic administration. Whereas, at species level, a higher abundance of Blautia producta, Blautia wexlerae and Haemophilus ducrey was observed, together with a reduction of Holdemania filiformis, Escherichia vulneris, Gemmiger formicilis and Streptococcus sinensis abundance. In addition, during follow-up period we observed a further reduction in Escherichia vulneris and Gemmiger formicilis, together with a decrease in Roseburia faecis and Ruminococcus gnavus abundance. Conversely, the abundance of Akkermansia muciniphila was increased if compared to samples collected at the beginning of the experimental time course CONCLUSION B. longum BB536 and L. rhamnosus HN001 showed the ability to modulate the gut microbiota composition, leading to a significant reduction of potentially harmful bacteria and an increase of beneficial ones. Further studies are needed to better understand the specific mechanisms involved in gut microbiota modulation. | Marco Toscano Roberta De Grandi Laura Stronati Elena De Vecchi Lorenzo Drago | 2017 | World Journal of Gastroenterology2017，23，15： | 14 |
| 2 | Prevention of nosocomial infections in neonatal intensive care units 显示文摘 | Manzoni P De Luca D Stronati M | 2013 | AmJPerinatol2013，30，2： | 1 |
| 3 | Congenital cytomegalovirus infection: treatment, sequelae and follow-up 显示文摘 | Lombardi G Garofoli F Stronati M | 2010 | J Matern Fetal Neonatal Med2010，23，3： | 1 |
| 4 | Obstetric risk factors for periventricular leukomalacia among preterm infants 显示文摘 | Spinillo A Capuzzo E Stronati M Ometto A De Santolo A Acciano S | 1998 | Br J Obstet Gynaecol1998，105，8： | 1 |
| 5 | Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma 显示文摘 | STRONATI L GENSABELLA G LAMBERIT C | 2002 | Cancer2002，92，： | 1 |
| 6 | Breastfeeding and cy-tomegalovirus infections显示文摘 | Stronati M Lombardi G Di Comite A | 2007 | J Chemother2007，19，2： | 1 |
| 7 | Strategies for the prevention of hospitalacquired infections in the neonatal intensive care unit显示文摘 | Borghesi A Stronati M | 2008 | J Hosp Infect2008，68，4： | 1 |
| 8 | Congenital cytomegalovirus infection: treatment, sequelae and follow-up显示文摘 | Lombardi G Garofoli F Stronati M | 2010 | J Matern Fetal Neonatal Med2010，23，3： | 1 |
| 9 | Congential cytomegalovirus infection显示文摘 | Lombardi G Stronati M | 2005 | Minerva Pediatr2005，57，3： | 1 |
| 10 | Evaluation of Genotoxic Effect of Low Level 50 Hz Magnetic Fields on Human Blood Cells Using Different Cytogenetic Assays 显示文摘 | Testa A Cordelli Stronati L | 2004 | Bioelectromagnetics2004，25，： | 1 |
| 11 | Bi-directional activation of inflammation and coagulation in septic neonates显示文摘 | Antonio Del Vecchio Mauro Stronati Caterina Franco Robert D. Christensen | 2014 | Early Human Development2014，，： | 1 |
| 12 | Human colostrum T lymphocytes and their effector cytokines actively aid the development of the newborn immune system 显示文摘 | Ciardelli L Garofoli F -Stronati M | 2008 | lnt J Immunopathol Pharmacol2008，21，4： | 1 |
| 13 | Early morbidity and neurodevelopmental outcome in low-birth weight infants born after third trimester bleeding显示文摘 | Spinillo A Fazzi E Stronati M | 1994 | Am J Perinatal1994，11，2： | 1 |
| 14 | Anomalies in sperm chromatin packaging: implications fnr assisted reproduction techniques显示文摘 | Tarozzi N Nadalini M Stronati A | 2009 | Reprod Biomed Online2009，18，4： | 1 |
| 15 | Early morbidity and neurodevelopmental outcome in low-birth weight infants 10om after third trimester bleeding显示文摘 | Spinillo A Fazzi E Stronati M | 1994 | Am J Perinatal1994，11，2： | 1 |
| 16 | Congenital cytomegalovirus infection:treatment,sequelae and follow-up显示文摘 | Lombardi G Garofoli F Stronati M | | 0，，3： | 1 |
| 17 | Fecal HMGB1 is a novel marker of intestinal mucosal inflammation in pediatric inflammatory bowel disease显示文摘 | Vitali R Stronati L Negroni A | | 0，，11： | 1 |
| 18 | Strategies for the prevention of hospital - acquired infections in the neonatal intensive care unit 显示文摘 | Borghesi A Stronati M | 2005 | J Hosp Infect2005，68，4： | 1 |
| 19 | Bi-directional activation of inflammation and coagulation in septic neonates显示文摘 | Del Vecchio A Stronati M Franco C | 2014 | Early Hum Dev2014，90，3： | 1 |
| 20 | Breastfeeding and cytomegalovirus infections 显示文摘 | Stronati M Lombardi G Di Comite A | 2007 | J Chemother2007，19，2： | 1 |
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