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| 1 | Fecal stream diversion and mucosal cytokine levels in collagenous colitis:A case report显示文摘In this case report, we examined the levels of cytokines expressed before and during fecal stream diversion and after intestinal continuity was restored in a patient with collagenous colitis. We report the case of a46-year-old woman with chronic, active collagenous colitis who either failed to achieve clinical remission or experienced adverse effects with the following drugs:loperamide, cholestyramine, budesonide, methotrexate and adalimumab. Due to the intractable nature of the disease and because the patient was having up to 15 watery bowel movements per day, she underwent a temporary ileostomy. Colonic biopsies were analyzed for mucosal cytokine protein levels before and during fecal stream diversion and after intestinal continuity was restored. Mucosal protein levels of interleukin(IL)-1β,IL-2, IL-6, IL-12, IL-17 A, IL-23, TNF, IFN-γ, IL-4, IL-5,IL-10 and IL-13 were all higher during active disease and decreased to non-detectable or considerably lower levels during fecal stream diversion. One month after the restoration of bowel continuity, when the patient experienced a relapse of symptoms, IL-2, IL-23 and IL-21 levels were again increased. Our results indicate that fecal stream diversion in this patient suppressed the levels of all cytokines analyzed in colonic biopsies. With the recurrence of clinical symptoms and histological changes after bowel reconstruction,the levels of primarily proinflammatory cytokines increased. Our findings support the hypothesis that a luminal factor triggers the inflammation observed in collagenous colitis. | Niki Daferera Ashok Kumar Kumawat Elisabeth Hultgren-Honquist Simone Ignatova Magnus Strom Andreas Münch | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 2 | PCR amplification of alleles at the D1SS0 Locus: Comparison of a Finish and a North American Caucasian population sample, and forensic caseworke evalution 显示文摘 | Sajantila A Budowle B Strom M | 1992 | Am J Hum Genet1992，50，： | 1 |
| 3 | Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy显示文摘 | Strom C C Aplin M Ploug T | 2005 | FEBS J2005，272，11： | 1 |
| 4 | Effect of mannanase and lipase on the properties of colloidal wood extractives and their interaction with mecharical pulp fines 显示文摘 | Rundlof M Efiksson M Strom H | 2002 | Cellulose2002，9，2： | 1 |
| 5 | standard for the management of ductal carcinoma in situ of the breast(DCIS) 显示文摘 | Morrow M Strom EA Bassett LW | 2002 | CA Cancer J Clin2002，52，5： | 1 |
| 6 | Standard for breast conservation therapy in the management of invasive breast carcinoma显示文摘 | Morrow M Strom E A Bassett L W | 2005 | CA Cancer J Clin2005，52，5： | 1 |
| 7 | Corrosion resistance of zinc-magnesium coated steel 显示文摘 | Hosking N C Strom M A Shipway P H | 2007 | Crossion Science2007，49，： | 1 |
| 8 | Corrosion resistance of zinc- magnesium coated steel 显示文摘 | Hosking N C Strom M A Shipway P H | 2007 | Corrosion Science2007，49，9： | 1 |
| 9 | Epidemiology and pathogenesis of Vibrio vulnificus显示文摘 | STROM M S PARANJPYE R N | 2000 | Microbes and Infection2000，2，： | 1 |
| 10 | The hofmeister effect and the behavior of water at interfaces显示文摘 | LeRudulier D Strom A R Dandekar A M | 1984 | Molecularbiology osmoregulation Science1984，224，4653： | 1 |
| 11 | Length of incubation for enumerating nitrifying bacteria present in various environments 显示文摘 | MATULEWICH V A STROM P F FINSTEIN M S | 1975 | Appl Microbiol1975，29，2： | 1 |
| 12 | A real-PCR assay for the rapid determination of 16S rRNA genotype in Vibrio vulnificus 显示文摘 | Vickery M C Nilsson W B Strom M S | 2007 | J Microbiol Methods2007，68，2： | 1 |
| 13 | Opportunities to reduce health inequalities by 'Health in All Policies' in the Neth- erlands: an explorative study on the national level 显示文摘 | Strom I Aarts M Harting J | 2011 | Health Policy2011，103，23： | 1 |
| 14 | Allogeneic stem cells, clinical transplantation and the origins of regenerative medicine 显示文摘 | Strom TB Field LJ Ruediger M | 2002 | Curr Opin Immunol2002，14，： | 1 |
| 15 | Does Greenlight HPS(TM) laser photoseleetive vaporization prostatectomy affect sexual function? 显示文摘 | SPALIVIERO M STROM K H GU X | 2010 | J Endourol2010，24，12： | 1 |
| 16 | The Spreading of Silicone Oil Droplets on a Surface with Parallel Shaped Grooves 显示文摘 | GERDES S CAZABAT A M STROM G | 1997 | Langmuir1997，13，26： | 1 |
| 17 | Length of incubation for enumerating nitrifying bacteria present in various environments显示文摘 | Strom P F Finstein M S | 1975 | Appl Microbiol1975，29，： | 1 |
| 18 | Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia con- genita and hypogonadotropic hypogonadism显示文摘 | Muscatelli F Strom T M Walker A P | 1994 | Nature1994，372，： | 1 |
| 19 | Intermediate outcomes of Green- Light HPSTM laser photoseleetivc vaporization prostatectomy for symptom- atic benign prostatic hyperplasia显示文摘 | Gu X Strom K Spaliviero M | 2011 | J Endourol2011，25，6： | 1 |
| 20 | Effect of mannanase and lipase on the properties of colloidal wood extracrives and their interaction with mechanical pulp fines显示文摘 | Rundlof M Eriksson M Strom H | 2002 | Cellulose2002，9，2： | 1 |
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