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| 1 | Migration of bone marrow progenitor cells in the adult brain of rats and rabbits显示文摘Neurogenesis takes place in the adult mammalian brain in three areas:Subgranular zone of the dentate gyrus(DG);subventricular zone of the lateral ventricle;olfactory bulb.Different molecular markers can be used to characterizethe cells involved in adult neurogenesis.It has been recently suggested that a population of bone marrow(BM)progenitor cells may migrate to the brain and differentiate into neuronal lineage.To explore this hypothesis,we injected recombinant SV40-derived vectors into the BM and followed the potential migration of the transduced cells.Long-term BM-directed gene transfer using recombinant SV40-derived vectors leads to expression of the genes delivered to the BM firstly in circulating cells,then after several months in mature neurons and microglial cells,and thus without central nervous system(CNS)lesion.Most of transgene-expressing cells expressed NeuN,a marker of mature neurons.Thus,BM-derived cells may function as progenitors of CNS cells in adult animals.The mechanism by which the cells from the BM come to be neurons remains to be determined.Although the observed gradual increase in transgene-expressing neurons over 16mo suggests that the pathway involved differentiation of BM-resident cells into neurons,cell fusion as the principal route cannot be totally ruled out.Additional studies using similar viral vectors showed that BM-derived progenitor cells migrating in the CNS express markers of neuronal precursors or immature neurons.Transgene-positive cells were found in the subgranular zone of the DG of the hippocampus 16 mo after intramarrow injection of the vector.In addition to cells expressing markers of mature neurons,transgene-positive cells were also positive for nestin and doublecortin,molecules expressed by developing neuronal cells.These cells were actively proliferating,as shown by short term BrdU incorporation studies.Inducing seizures by using kainic acid increased the number of BM progenitor cells transduced by SV40vectors migrating to the hippocampus,and these cells were seen at earlier time points in the DG.We show that the cell membrane chemokine receptor,CCR5,and its ligands,enhance CNS inflammation and seizure activity in a model of neuronal excitotoxicity.SV40-based gene delivery of RNAi targeting CCR5 to the BM results in downregulating CCR5 in circulating cells,suggesting that CCR5 plays an important role in regulating traffic of BM-derived cells into the CNS,both in the basal state and in response to injury.Furthermore,reduction in CCR5 expression incirculating cells provides profound neuroprotection from excitotoxic neuronal injury,reduces neuroinflammation,and increases neuronal regeneration following this type of insult.These results suggest that BM-derived,transgeneexpressing,cells can migrate to the brain and that they become neurons,at least in part,by differentiating into neuron precursors and subsequently developing into mature neurons. | Donnahue Dennie Jean-Pierre Louboutin David S Strayer | 2016 | World Journal of Stem Cells2016，8，4： | 9 |
| 2 | How learning in an inverted classroom influences cooperation, innovation and task orientation显示文摘 | Jeremy Strayer | 2012 | Learning Environments Research2012，，2： | 5 |
| 3 | Analysis of the function of two circadian-regulated CONSTANS-LIKE genes显示文摘 | LEDGER S STRAYER C ASHTON F | 2001 | Plant J2001，26，1： | 1 |
| 4 | Performance characterization of video-shot-change detection methods 显示文摘 | Gargi U Kasturi R Strayer S H | 2000 | IEEE Transactions on Circuits and Systems for Video Technology2000，10，1： | 1 |
| 5 | Diabetes and risk of incident colorectal cancer in a prospective cohort of women显示文摘 | Flood A Strayer L Schairer C | 2010 | Cancer Causes Control2010，21，8： | 1 |
| 6 | The 70-gene signa- ture as a response predictor for neoadjuvant chemotherapy in breast cancer 显示文摘 | Strayer ME Glas AM Hannemann J | 2010 | Breast Cancer Res Treat2010，119，3： | 1 |
| 7 | Current status of gene therapy strategies to treat HIV/AIDS显示文摘 | STRAYER D S AKKINA R BUNNELL B A | 2005 | Mol Ther2005，11，6： | 1 |
| 8 | Understanding the long-term effects of speciesinvasions 显示文摘 | Strayer D L Eviner V T Jeschke J M | 2006 | Trends in Ecology & Evolution2006，21，11： | 1 |
| 9 | Pefformance characterization of video-shot-change detection Methods显示文摘 | Gargi U Kasturi R Strayer S H | 2000 | IEEE Transaction on Circuits and Systems for Video Technology2000，10，1： | 1 |
| 10 | Chiari I malformation:clinical presentation and management显示文摘 | Strayer A | 2001 | Neursci Nuts2001，33，2： | 1 |
| 11 | Cell phone-induced failures of visual attention during simulated driving显示文摘 | Strayer D L Drews F A Johnston W A | 2003 | Journal of Experimental Psychology: Applied2003，9，1： | 1 |
| 12 | How learning in an inverted classroom in-fluences cooperation, innovation and task orientation 显示文摘 | STRAYER J F | 2012 | Learning Environ Res2012，，15： | 1 |
| 13 | Oxygen,organic matter,and sediment granulometry as controls on hyporheic animal communities显示文摘 | Strayer D L May S E Nielsen P | 1997 | Arch Hydrobiology1997，140，： | 1 |
| 14 | Exercise capacity and immune function in male and female patients with chronic fatigue syndrome显示文摘 | Snell CR Vanness JM Strayer DR | 2005 | In Vivo2005，19，2： | 1 |
| 15 | Current status of gene therapy strategies to treat HIV/AIDS显示文摘 | Strayer D S Akkina R Bunnell B A | 2005 | Mol Ther2005，11，6： | 1 |
| 16 | American journal of physiology 显示文摘 | Strayer M Savani BC Gonzales LW et aL Human surfac- tant protein B promoter in transgenic mice: temporal spa- tial and stimulus-responsive regulation | 2002 | Lung Cell Mol Physiol2002，282，： | 1 |
| 17 | Individual differ- ences in working memory capacity predict action monitoring and the error-related negativity 显示文摘 | Miller AE Watson JM Strayer DL | 2012 | J Exp Psychol Learn Mem Cogn2012，38，3： | 1 |
| 18 | Sentinel node identification rate and nodal involvement in the EORTC 10981-22023 AMAROS trial显示文摘 | Strayer ME Meijnen P van Tienhoven G | 2010 | VeronAnn Surg Onco12010，17，7： | 1 |
| 19 | How learning in an inverted classroom influences cooperation, innovation and task orientation显示文摘 | Strayer J F | 2012 | Learning Environ Res2012，，15： | 1 |
| 20 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
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