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| 1 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 2 | Risk management of renal biopsy:1387 cases over 30 years in a single centre显示文摘 | Canavese C Marengo M | 2007 | Eur J Clin Invest2007，37，12： | 1 |
| 3 | Pregnancy in kidney transplantation: satisfactory outcomes and harsh realities 显示文摘 | Stratta P Canavese C Giacchino F | 2003 | J Nephrol2003，16，6： | 1 |
| 4 | The case for oxygen free radicals in the pathogenesis of ischemic acute renal failure显示文摘 | CANAVESE C STRATTA P VERCELLONE A | 1988 | Nephron1988，49，： | 1 |
| 5 | Risk management of renal bi- opsy:1387 cases over 30 years in a single centre 显示文摘 | Stratta P Canavese C Marengo M | 2007 | Eur J Clin In- vest2007，37，12： | 1 |
| 6 | Pregnancy in patients with kid- ney disease显示文摘 | Stratta P Canavese C Quaglia M | 2006 | J Nephrol2006，19，2： | 1 |
| 7 | Risk management of renal biopsy: 1387 cases over 30 years in a single centre显示文摘 | Stratta P Canavese C Marengo M | 2007 | Eur J Clin Invest2007，37，12： | 1 |
| 8 | Malignancy after kidney transplantation: results of 400 patients from a single center 显示文摘 | Stratta P Morellini V Musetti C | 2008 | Clin Transplant2008，22，4： | 1 |
| 9 | Oxygen free radicals in nephrology显示文摘 | Canavese C Stratta P | 1987 | Int J Art Organs1987，10，： | 1 |
| 10 | Think of oxalate when using ascorbate supplementation to optimize iron therapy in dialysis patients显示文摘 | Canavese C Marangella M Stratta P | 2008 | Nephrol Dial Transplant2008，23，4： | 1 |
| 11 | Medullary sponge kidney 显示文摘 | Stratta P Canavese C Lazzarich E | 2006 | Am J Kidney Dis2006，48，6： | 1 |
| 12 | New trends of an old disease : the acute post infectious glomerulonephritis at the beginning of the new millenium显示文摘 | Stratta P Musetti C Barreca A | 2014 | J Nephrol2014，27，3： | 1 |
| 13 | Pregnancy in kidney transplantation:satisfactory outcomes and harsh realities显示文摘 | Stratta P Canavese C Giacchino F | | 0，，06： | 1 |
| 14 | Pregnancy in kidney transplantation: satisfactory outcomes and harsh realities 显示文摘 | Stratta P Canavese C Giacchino F | 2003 | J Nephrol2003，16，： | 1 |
| 15 | Resilience and cop- ing in trauma spectrum symptoms prediction:A structural equation modeling approach 显示文摘 | Stratta R Capanna C | 2015 | Personality and individual difference2015，77，： | 1 |
| 16 | Risk management of renal bi- opsy:1387 cases over 30 years in a single centre 显示文摘 | Stratta P Canavese C Marengo M | 2007 | Eur J Clin In- vest2007，37，12： | 1 |
| 17 | Pregnancy in kidney transplantation:satisfactory outcomes and harsh realities显示文摘 | Canavese C Giacchino F | 2003 | J Nephrol2003，16，6： | 1 |
| 18 | Thromboelastogram monitoring in the perioperative period of hepatectomy for adult living liver donation显示文摘 | Cerutti E Stratta C Romagnoli R | 2004 | Liver Transpl2004，10，2： | 1 |
| 19 | Angiotensin I-Converting enzyme genotype significantly affects progression of IgA glomerulonephritis in an Italian population显示文摘 | Stratta P Canavese C Ciccone G | 1999 | Am J Kidney Dis1999，33，6： | 1 |
| 20 | Drug-induced erythropoiesis and outcome: should we give up the haemoglobin target approach and return to the ratio between erythropoiesis-stimulating agents and haemoglobin?显示文摘 | Canavese C Salomone M Stratta P | 2012 | Nephrol Dial Transplant2012，27，1： | 1 |
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