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| 1 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 2 | Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?显示文摘减少的 cavernosal 在肾通过端对端的吻合在接受者移植 revascularized 到内部肠骨的动脉以后,动脉的流入被假设了是可勃起的机能障碍的可能的原因,在外部肠骨的动脉建议那 end-to-side 吻合更好。学习是有希望地由评估在可勃起的功能,荷尔蒙侧面和阴茎血流动上评估外部肠骨的动脉的使用的效果的这的目的在 end-to-side 前后在 22 个接受者的一个连续系列在阴茎颜色 Doppler 超声参数变化外部肠骨的动脉移植。可勃起的功能可勃起的函数(IIEF-EF ) 领域 20 的吝啬的国际索引显著地减少了 3 个月在以后移植(18.09 ± 6.33 对 22.50 ± 7.09, P=0.01 ) 。在山峰的减小收缩速度(PSV ) 为到方面的多孔的动脉 homolateral 是重要的移植(42.60 ± 18.77 对 52.01 ± 19.91, P=0.01 ) 。吝啬的手术后的目的心脏舒张的速度(EDV ) 没与外科手术前的价值(P=0.74 ) 显著地不同。没有统计差别在睾丸激素或催乳激素的浆液层次被发现。在外部肠骨的动脉吻合的肾接枝生产了重要(P=0.01 ) 在在在正常阀值上面留下了的 homolateral cavernosal 动脉的动脉的流入的减小。这些 haemodynamic 是否变化,能解释要证明的手术后的可勃起的功能遗体变得更坏。 | Paolo Gontero Marco Oderda Claudia Filippini Francesco Fontana Elisa Lazzarich Piero Stratta Ernesto Turello Alessandro Tizzani Bruno Frea | 2012 | Asian Journal of Andrology2012，14，4： | 2 |
| 3 | Liver bioengineering:Current status and future perspectives显示文摘The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes.There are two general pathways to liver bioengineering and regeneration.The first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in vivo.This strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human origin.Liver bioengineering has potential for transplantation and for toxicity testing during preclinical drug development.The second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell pathways.In fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver volume.Infusion of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine strategies.As well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate. | Christopher Booth Tom Soker Pedro Baptista Christina L Ross Shay Soker Umar Farooq Robert J Stratta Giuseppe Orlando | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 4 | Impact of the metabolic syndrome on long-term outcomes in simultaneous kidney-pancreas transplantation显示文摘 | Rogers J Stratta RJ Lo A | 2005 | Transplant Proc2005，37，8： | 1 |
| 5 | Decision-making impairment in schizophrenia : relationships with positivesymptomatology 显示文摘 | STRUGLIA F STRATTA P GIANFEUCE D | 2011 | Neurosci Lett2011，502，2： | 1 |
| 6 | Idiopthic membranous nephropathy:management strategies显示文摘 | Quaglia M Stratta P | | 0，，10： | 1 |
| 7 | Vascular complications after orthotopic liver transplantation显示文摘 | Langnas AN Marujo WC Stratta RJ | 1991 | Am J Surg1991，161，： | 1 |
| 8 | Risk management of renal biopsy:1387 cases over 30 years in a single centre显示文摘 | Canavese C Marengo M | 2007 | Eur J Clin Invest2007，37，12： | 1 |
| 9 | Syndrome of multiple bowel perforations in liver transplant recipients 显示文摘 | Marujo WC Stratta RJ Langnas AN | 1991 | Am J Surg1991，162，6： | 1 |
| 10 | Successful reuse of portal-enteric technique in pancreas retransplantation 显示文摘 | Reddy KS Shokouh-Amiri H Stratta RJ | 2000 | Transplantation2000，69，11： | 1 |
| 11 | Vascular complications after orthotopic liver transplantation显示文摘 | Langnas AN Marujo W Stratta RJ | 1991 | AmJ Surg1991，161，1： | 1 |
| 12 | Regenerativemedicine and organ transplantation:past,present,andfuture显示文摘 | Orlando G Wood KJ Stratta RJ | 2011 | Transplantation2011，91，12： | 1 |
| 13 | Early diagnosis and treatment of pancreas allograft rejection 显示文摘 | Stratta RJ Sollinger HW Perlman SB | 1988 | Transplant Int1988，1，1： | 1 |
| 14 | Pregnancy in kidney transplantation: satisfactory outcomes and harsh realities 显示文摘 | Stratta P Canavese C Giacchino F | 2003 | J Nephrol2003，16，6： | 1 |
| 15 | Tower of Hanoi and WCST performance in schizophrenia: Problem--solving capacity and clini- cal correlates显示文摘 | Bustini M Stratta P Daneluzzo E | 1999 | J Psychiatr Res1999，33，3： | 1 |
| 16 | Vascular complication after orthotopic transplantation显示文摘 | Marujo W Stratta RT | 1991 | Am J Surg1991，161，1： | 1 |
| 17 | Is Wisconsin Card Sorting Test performance related to ' working memory' capacity7 显示文摘 | Stratta P Daneluzzo E Prosperini P | 1997 | Schizophr Res1997，27，： | 1 |
| 18 | Successful unin- tentional ABO-incompatible renal transplantation: Blood group A1B donor into an A2B recipient显示文摘 | Fadeyi EA Stratta R J Farney AC | 2014 | Am J Clin Pathol2014，141，5： | 1 |
| 19 | Role of surveillance biopsies in monitoring recipients of pancreas alone transplants显示文摘 | Stratta RJ Lo A | 2001 | Transplant Proc2001，33，12： | 1 |
| 20 | Vascular complications after orthotopic liver transplantation显示文摘 | Langnas AN Marujo WC Stratta RJ | 1991 | Am J Surg1991，161，2： | 1 |
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