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| 1 | Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver显示文摘Spontaneous bacterial peritonitis(SBP) is a frequent, life-threatening bacterial infection in patients with liver cirrhosis and ascites. Portal hypertension leads to increased bacterial translocation from the intestine. Failure to eliminate invading pathogens due to immune defects associated with advanced liver disease on the background of genetic predisposition may result in SBP. The efficacy of antibiotic treatment and prophylaxis has declined due to the spread of multi-resistant bacteria. Patients with nosocomial SBP and with prior antibiotictreatment are at a particularly high risk for infection with resistant bacteria. Therefore, it is important to adapt empirical treatment to these risk factors and to the local resistance profile. Rifaximin, an oral, nonabsorbable antibiotic, has been proposed to prevent SBP, but may be useful only in a subset of patients. Since novel antibiotic classes are lacking, we have to develop prophylactic strategies which do not induce bacterial resistance. Farnesoid X receptor agonists may be a candidate, but so far, clinical studies are not available. New diagnostic tests which can be carried out quickly at the patient's site and provide additional prognostic information would be helpful. Furthermore, we need tools to predict antibiotic resistance in order to tailor first-line antibiotic treatment of spontaneous bacterial peritonitis to the individual patient and to reduce mortality. | Philipp Lutz Hans Dieter Nischalke Christian P Strassburg Ulrich Spengler | 2015 | World Journal of Hepatology2015，7，3： | 12 |
| 2 | Hepatic encephalopathy before and neurological complications after liver transplantation have no impact on the employment status 1 year after transplantation显示文摘AIM To investigate the impact of hepatic encephalopathybefore orthotopic liver transplantation(OLT) and neurological complications after OLT on employment after OLT.METHODS One hundred and fourteen patients with chronic liver disease aged 18-60 years underwent neurological examination to identify neurological complications, neuropsychological tests comprising the PSE-SyndromeTest yielding the psychometric hepatic encephalopathy score, the critical flicker frequency and the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS), completed a questionnaire concerning their occupation and filled in the short form 36(SF-36) to assess health-related quality of life before OLT and 12 mo after OLT, if possible. Sixty-eight(59.6%) patients were recruited before OLT, while on the waiting list for OLT at Hannover Medical School [age: 48.7 ± 10.2 years, 45(66.2%) male], and 46(40.4%) patients were included directly after OLT. RESULTS Before OLT 43.0% of the patients were employed. The patients not employed before OLT were more often non-academics(employed: Academic/non-academic 16(34.0%)/31 vs not employed 10(17.6%)/52, P = 0.04), had more frequently a history of hepatic encephalopathy(HE)(yes/no; employed 15(30.6%)/34 vs not employed 32(49.2%)/33, P = 0.05) and achieved worse results in psychometric tests(RBANS sum score mean ± SD employed 472.1 ± 44.5 vs not employed 443.1 ± 56.7, P = 0.04) than those employed. Ten patients(18.2%), who were not employed before OLT, resumed work afterwards. The patients employed after OLT were younger [age median(range, min-max) employed 47(42, 18-60) vs not employed 50(31, 29-60), P = 0.01], achieved better results in the psychometric tests(RBANS sum score mean ± SD employed 490.7 ± 48.2 vs not employed 461.0 ± 54.5, P = 0.02) and had a higher health-related quality of life(SF 36 sum score mean ± SD employed 627.0 ± 138.1 vs not employed 433.7 ± 160.8; P < 0.001) compared to patients not employed after OLT. Employment before OLT(P < 0.001), age(P < 0.01) and SF-36 sum score 12 mo after OLT(P < 0.01) but not HE before OLT or neurological complications after OLT were independent predictors of the employment status after OLT.CONCLUSION HE before and neurological complications after OLT have no impact on the employment status 12 mo after OLT. Instead younger age and employment before OLT predict employment one year after OLT. | Henning Pflugrad Anita B Tryc Annemarie Goldbecker Christian P Strassburg Hannelore Barg-Hock Jürgen Klempnauer Karin Weissenborn | 2017 | World Journal of Hepatology2017，9，10： | 3 |
| 3 | Conservation of an alpha 2 domain within the telenseanworld, MHC class I from therainbow trout Oncorhynchus mykiss 显示文摘 | Hansen J D Strassburger P D Pasquier L | 1996 | Dev Comp lmmunol1996，20，： | 1 |
| 4 | Autoantibodies and autoantigens in autoimmune hepatitis显示文摘 | Strassburg C P Manns M P | 2002 | Semin Liver Dis2002，22，： | 1 |
| 5 | Ovarian function before and after salpingectomy in artificial reproductive technology patients 显示文摘 | Dar P Sachs GS Strassburger D | 2000 | Hum Reprod2000，15，1： | 1 |
| 6 | Ovarian function before and after salpingectomy in artificial reproductive technology pa- tients显示文摘 | Dar P Sachs GS Strassburger D | 2000 | Hum Reprod2000，15，1： | 1 |
| 7 | CdTe CdZnTe under high flux irradiation显示文摘 | Strassburg M Schroeter C Hackenschmied P | | 0，，： | 1 |
| 8 | Ovarian function before and after salpingectomy in artificial reproductive technology patients显示文摘 | Dar P Sachs GS Strassburger D | 2000 | Hum Reprod2000，15，1： | 1 |
| 9 | Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase:UGT2B7显示文摘 | Strassburg CP Barut A Obermayer-Straub P | 2001 | J Hepatol2001，34，6： | 1 |
| 10 | Portopulmonary hypertension and hepatopulmonary syndrome显示文摘 | Marius M Hoeper Michael J Krowka Christian P Strassburg | 2004 | The Lancet . 2004 (9419)2004，，9419： | 1 |
| 11 | Human UDP-glucuronosyhransferas- es: metabolism, expression, and disease 显示文摘 | Tukey R H Strassburg C P | 2000 | Annu Rev Phar- macol Toxicol2000，40，1： | 1 |
| 12 | Autoimmune hepatitis:clinical challenges显示文摘 | Manns M P Strassburg C P | | 0，，06： | 1 |
| 13 | Ovarian function before and after salpingectomy in artificial reproductive technology 显示文摘 | Dar P Sachs AS Strassburger D | 2000 | Hum Reprod2000，15，1： | 1 |
| 14 | A comparison of the structure and dynamics of avian pancreatic polypeptide hormone in solution and in the crystal显示文摘 | Kruger P Strassburger W Wollmer A | 1985 | Eur Biophys J1985，13，2： | 1 |
| 15 | Autoimmune hepatitis 显示文摘 | Obermayer - Straub P Strassburg CP Manns MP | 2000 | J Hepatol2000，32，1： | 1 |
| 16 | Portopulmonary hypertension and hepatopulmonary syndrome显示文摘 | Marius M Hoeper Michael J Krowka Christian P Strassburg | 2004 | The Lancet2004，，9419： | 1 |
| 17 | Description of an ectothermic TCR coreceptor, CD8, in rainbow trout 显示文摘 | Hansen J D Strassburger P | 2000 | Immunology2000，164，： | 1 |
| 18 | Target Proteins in human autoimmunity:cytochromes P450 and UDP-glucuronosyltransferases显示文摘 | Obermayer-Straub P Strassburg CP Manns MP | 2000 | Can J Gastroenterol2000，14，5： | 1 |
| 19 | Human UDP-glucuronosyltransferas- es : metabolism, expression, and disease显示文摘 | Tukey R H Strassburg C P | 2000 | Annu Rev Pharma- col2000，40，1： | 1 |
| 20 | Autoimmune hepatitis:clinical challenges显示文摘 | Manns M P Strassburg C P | 2001 | Gastroenterology2001，120，6： | 1 |
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