|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Moving from control to elimination of schistosomiasis in sub-Saharan Africa:time to change and adapt strategies显示文摘Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing.In sub-Saharan Africa,for example,the landscape is becoming ever more heterogeneous as there are several species of Schistosoma that respond in different ways to ongoing preventive chemotherapy and the inter-sectoral interventions currently applied.The major focus of preventive chemotherapy is delivery of praziquantel by mass drug administration to those shown to be,or presumed to be,at-risk of infection and disease.In some countries,regional progress may be uneven but in certain locations there are very real prospects to transition from control into interruption of transmission,and ultimately elimination.To manage this transition requires reconsideration of some of the currently deployed diagnostic tools used in surveillance and downward realignment of existing prevalence thresholds to trigger mass treatment.A key challenge will be maintaining and if possible,expanding the current donation of praziquantel to currently overlooked groups,then judging when appropriate to move from mass drug administration to selective treatment.In so doing,this will ensure the health system is adapted,primed and shown to be cost-effective to respond to these changing disease dynamics as we move forward to 2020 targets and beyond. | Louis-Albert Tchuem Tchuente David Rollinson JRussell Stothard David Molyneux | 2017 | Infectious Diseases of Poverty2017，6，1： | 8 |
| 2 | Urogenital schistosomiasis and soiltransmitted helminthiasis(STH)in Cameroon:An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions显示文摘Background:The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously.To collect contemporary epidemiological information,a cross-sectional survey was undertaken inclusive of:signs and symptoms of disease,individual treatment histories,local water,sanitation and hygiene(WASH)-related factors and malacological surveillance,with molecular characterisation of specimens.Methods:At each lake,a community cross-sectional survey was undertaken using a combination of stool and urine parasitological sampling,and interview with pro-forma questionnaires.A total of 338 children and adults participated.Material from snail and parasite species were characterised by DNA methods.Results:Egg-patent prevalence of urogenital schistosomiasis was 8.7%at Barombi Mbo(all light-intensity infections)and 40.1%at Barombi Kotto(21.2%heavy-intensity infections).Intestinal schistosomiasis was absent.At Barombi Kotto,significantly more women reported signs and symptoms associated with female genital schistosomiasis.While there had been extensive recent improvement in WASH-related infrastructure at Barombi Mbo,water contact risk scores were higher among schistosomiasis-infected participants(P<0.001)and at Barombi Kotto in general(P<0.001).Across both lakes,mean prevalence of STH was very low(6.3%)evidencing an impressive decrease of 79.0%over the last decade;neither Strongyloides stercoralis nor Ascaris lumbricoides were found.A total of 29 freshwater sampling sites were inspected for snails,13 in Barombi Mbo and 16 in Barombi Kotto;water chemistry differed significantly(P<0.0001)between lakes for both mean pH(7.9 v.9.6)and mean conductivity(64.3μS v.202.1μS)respectively.Only two Bulinus camerunensis found on the central island of Barombi Kotto were observed to shed schistosome cercariae,but schistosome DNA was later detected in Bulinus sampled from both lakes as well as in Indoplanorbis exustus,an invasive species from Asia.Conclusions:STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto.This assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes,to evaluate future intensified interventions both in terms of gaining and sustaining control at Barombi Kotto or in moving towards local interruption of transmission of both diseases at Barombi Mbo. | Suzy J.Campbell J.Russell Stothard Faye O’Halloran Deborah Sankey Timothy Durant Dieudonne Eloundou Ombede Gwladys Djomkam Chuinteu Bonnie LWebster Lucas Cunningham EJames LaCourse Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 3 | Intestinal schistosomiasis in Uganda at high altitude(>1400 m):malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs显示文摘Background:Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission is thought unlikely.To assess altitudinal boundaries and at-risk populations,conjoint malacological and epidemiological surveys were undertaken on Mount Elgon(1139 m-3937 m),in Fort Portal crater lakes and in the Rwenzori Mountains(1123 m-4050 m).Methods:Seventy freshwater habitats[Mount Elgon(37),Fort Portal crater lakes(23),Rwenzori Mountains(8)and Lake Albert(2)]were inspected for Biomphalaria species.Water temperature,pH and conductivity were recorded.A parasitological examination of 756 schoolchildren[Mount Elgon(300),Fort Portal crater lakes(456)]by faecal microscopy of duplicate Kato-Katz smears from two consecutive stool samples was bolstered by antigen(urine-CCA dipstick)and antibody(SEA-ELISA)diagnostic assays.Results:Biomphalaria spp.was found up to 1951 m on Mount Elgon and 1567 m in the Fort Portal crater lakes.Although no snail from Mount Elgon shed cercariae,molecular analysis judged 7.1%of snails sampled at altitudes above 1400 m as having DNA of Schistosoma mansoni;in Fort Portal crater lakes three snails shed schistosome cercariae.Prevalence of intestinal schistosomiasis as measured in schoolchildren by Kato-Katz(Mount Elgon=5.3%v.Fort Portal crater lakes=10.7%),CCA urine-dipsticks(18.3%v.34.4%)and SEA-ELISA(42.3%v.63.7%)showed negative associations with increasing altitude with some evidence of infection up to 2000 m.Conclusions:Contrary to expectations,these surveys clearly show that natural transmission of intestinal schistosomiasis occurs above 1400 m,possibly extending up to 2000 m.Using spatial epidemiological predictions,this now places some extra six million people at-risk,denoting an expansion of preventive chemotherapy needs in Uganda. | Michelle CStanton Moses Adriko Moses Arinaitwe Alison Howell Juliet Davies Gillian Allison EJames LaCourse Edridah Muheki Narcis BKabatereine J.Russell Stothard | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 4 | Towards interruption of schistosomiasis transmission in sub-Saharan Africa:developing an appropriate environmental surveillance framework to guide and to support‘end game’interventions显示文摘Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa,particularly common in rural populations living in impoverished conditions.With the scale-up of preventive chemotherapy,national campaigns will transition from morbidity-to transmission-focused interventions thus formal investigation of actual or expected declines in environmental transmission is needed as‘end game’scenarios arise.Surprisingly,there are no international or national guidelines to do so in sub-Saharan Africa.Our article therefore provides an introduction to key practicalities and pitfalls in the development of an appropriate environmental surveillance framework.In this context,we discuss how strategies need to be adapted and tailored to the local level to better guide and support future interventions through this transition.As detection of egg-patent infection in people becomes rare,careful sampling of schistosome larvae in freshwater and in aquatic snails with robust species-specific DNA assays will be required.Appropriate metrics,derived from observed prevalence(s)as compared with predetermined thresholds,could each provide a clearer insight into contamination-and exposure-related dynamics.Application could be twofold,first to certify areas currently free from schistosomiasis transmission or second to red-flag recalcitrant locations where extra effort or alternative interventions are needed. | J.Russell Stothard Suzy J.Campbell Mike Y.Osei-Atweneboana Timothy Durant Michelle C.Stanton Nana-Kwadwo Biritwum David Rollinson Dieudonne R.Eloundou Ombede Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 5 | Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar显示文摘School-aged children(SAC)have a considerable burden of intestinal schistosomiasis in Madagascar yet its burden in pre-school aged children(PSAC)is currently overlooked.To assess the at-risk status of PSAC,we undertook a pilot epidemiological survey in June 2019 examining children(n=89),aged 2-4-years of balanced gender,in six remote villages in Marolambo District,Madagascar.Diagnosis included use of urine-circulating cathodic antigen(CCA)dipsticks and coproscopy of stool with duplicate Kato-Katz(K-K)thick smears. | Caitlin Sheehy Heather Lawson Emmanuel H.Andriamasy Hannah J.Russell Alice Reid Gina U.Raderalazasoa Graham Dodge Robbie Kornitschky James M.StJPenney Tahiry N.Ranaivoson Antsa Andria niaina Jenny S.Emmanoela Amaya L.Bustinduy JRussell Stothard Louis Andrianjaka Stephen A.Spencer | 2021 | Infectious Diseases of Poverty2021，10，3： | 2 |
| 6 | Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis显示文摘 | Stothard KJ Tennant PW Bell R | 2009 | JAMA2009，301，6： | 1 |
| 7 | Fluorescent oligonucleotide probes for clinical and environmental detection of Acanthamoeba and the T4 18S rRNA gene sequence type显示文摘 | Stothard DR Hay J Schroeder-Diedrich JM | 1999 | Journal of Clinical Microbiology1999，37，8： | 1 |
| 8 | Use of circu- lating cathodic antigen (CCA) dipsticks for detection of intestinal and urinary schistosomiasis 显示文摘 | Stothard JR Kabatereine NB Tukahebwa EM | 2006 | Acta Trop2006，97，2： | 1 |
| 9 | A comparison of phonological skills in chil- dren with reading comprehension difficulties and children with de- coding difficulties 显示文摘 | Stothard SE Hulme C | 1995 | Child Psychol Psychiatry1995，36，3： | 1 |
| 10 | An evaluation of random amplified polymorphic DNA(RAPD) for identification and phylogeny of freshwater snails of the genus Bulinus (Gastropoda,Planorbidae)显示文摘 | Stothard J R | 1996 | J Moll Stud1996，，62： | 1 |
| 11 | Maternal overweight and obesity and the risk of congenital anomalies:a systematic review and meta-analysis显示文摘 | Stothard KJ Tennant PW Bell R | | 0，，06： | 1 |
| 12 | Comparison of continuous-wave optical parametric oscillators based on periodically poled LiNbO3 and periodically poled RbTiOAsO4 pumped internal to a high-power Nd∶YVO4laser显示文摘 | STOTHARD D J M FORTIN P Y CARLETON A | 2003 | J Opt Soc Am B2003，20，10： | 1 |
| 13 | The Sequence Manipulation Suite:JavaScript programs for analyzing and formatting protein and DNA sequences显示文摘 | Stothard P | 2000 | Biotechniques2000，28，： | 1 |
| 14 | Rho and Rac but not Cdc42 regulate endothelial cell permeability显示文摘 | Wojciak Stothard B Potempa S Eichholtz T | 2001 | J Cell Sci2001，114，7： | 1 |
| 15 | Continuous-wave,pump-enhanced optical parametric oscillator based on periodically poled RbTiOAsO4显示文摘 | LINDSAY I D STOTHARD D J M RAE C F | 2003 | Opt Express2003，11，2： | 1 |
| 16 | Molecu lar epidemiology of Schistosoma mansoni in Uganda: DNA barcoding reveals substantial genetic diversity within Lake Albert and Lake Victoria populations显示文摘 | STOTHARD J R WEBSTER B L WEBER T | 2009 | ParasitoZogy2009，136，18： | 1 |
| 17 | The evolutionary history of the genus Acantharrtoeba and the identification of eight new 18S rRNA gene sequence types显示文摘 | Stothard DR Schroeder-Diedrich JM Awwad MH et ol | 1988 | J Eukaryot Microbiol1988，45，1： | 1 |
| 18 | Maternal overweight and obesity and the risk of congenital anomalies:A systematic review and meta-analysis显示文摘 | Stothard KJ Tennant PW Bell R | 2009 | JAMA2009，301，6： | 1 |
| 19 | Recurrent carpal tunnel syndrome-analysis of the impact of patient personality in al- tering functional outcome following a vascularised hy- pothenar fat pad flap surgery显示文摘 | Karthik K Nanda R Stothard J | 2012 | J Hand Microsurg2012，4，1： | 1 |
| 20 | A systematic review of the treatment of acute fractures of the scaphoid显示文摘 | Symes TH Stothard J | 2011 | J Hand Surg Eur Vol2011，36，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员