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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease显示文摘To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease.In this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease.The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion.Although no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra.Furthermore,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia nigra.Hence,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.The study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014. | Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon | 2021 | Neural Regeneration Research2021，16，6： | 3 |
| 3 | The physiology of brain histamine显示文摘 | Brown RE Stevens DR Haas HL | 2001 | Prog Neurobiol2001，63，6： | 1 |
| 4 | Relationship between symptoms and health-related quality of life in patients treated for hypertension 显示文摘 | Steven RE Pharm D Brent CW | 2004 | Pharmacotherapy2004，24，3： | 1 |
| 5 | Chemilum inescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease显示文摘 | Simmonds NJ Allen RE Stevens TR | 1992 | Gastroenterology1992，103，1： | 1 |
| 6 | The physiology of brain histamine显示文摘 | Brown RE Stevens DR Haas HL | 2001 | Prog Neurobio2001，63，6： | 1 |
| 7 | Studies on prostate cancer: effects of castration on advanced carcinoma of the prostate gland显示文摘 | Stevens RE Hodges CV | 1941 | Arch Surg1941，43，3： | 1 |
| 8 | The physiology of brain histamine 显示文摘 | Brown RE Stevens DR Haas HL | 2001 | Prog Neurobiol2001，63，5： | 1 |
| 9 | The physiology of brain histamine显示文摘 | Brown RE Stevens DR Haas HL | 2001 | Prog Neurobiol2001，63，： | 1 |
| 10 | Detection of hyperacute primary intraparenchymal hemorrhage by magnetic resonance imaging显示文摘 | Mahesh RP Robert RE Steven W | 1996 | Stroke1996，27，12： | 1 |
| 11 | Bioavailability study of a 1 200 mg miconazole nitrate vaginal ovule in healthy female adults显示文摘 | Stevens RE Konsil J Verrill SS | 2002 | J Clin Pharmacol2002，42，1： | 1 |
| 12 | Relationship between symptoms and health - related quality of life in patients treated for hypertension 显示文摘 | Steven RE Plarm D Brent CW | 2004 | Pharmacotherapy2004，24，3： | 1 |
| 13 | The structural basis of phenylketonuria显示文摘 | Erlandsen H Stevens Re | 1999 | Mol C eaet Metab1999，68，2： | 1 |
| 14 | Studies on prostatic cancer II :the effect of castration on advanced carcinoma of the prostate gland显示文摘 | Huggins C Stevens RE JrHodges CV | 1941 | Arch Surg1941，43，2： | 1 |
| 15 | Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism 显示文摘 | Narayanan B Stevens MC Jiantonio RE et aL | 2013 | J Stud Alcohol Drugs2013，74，2： | 1 |
| 16 | Studies on advanced carcinomaof the prostate gland显示文摘 | Huggis C Stevens RE Hodges CV | 1941 | Arch Surg1941，43，： | 1 |
| 17 | The physiology of brain histamine显示文摘 | Brown RE Stevens DR Haas HL | 2001 | Progress in Neurobiology2001，63，6： | 1 |
| 18 | Lung tumorigenicity of benzene oxide, benzene dihydrodiols and benzene dioepoxides in the BLU:Ha newborn mouse assay显示文摘 | Busby WF Jr Wang JS Stevens EK Padykula RE Aleksejczyk RA Berchtold GA | 1990 | Carcinogenesis1990，11，9： | 1 |
| 19 | Bioavailability study of a 1200mg miconazole nitrate vaginal ovule in Healthy Female Adults 显示文摘 | Stevens RE Konsil J Verrill SS | 2002 | J Chin Phannacol2002，42，1： | 1 |
| 20 | A comparison of staging systems for nasopharyngeal carcinoma显示文摘 | Cooper JS Cohen R Stevens RE | 1998 | Cancer1998，83，2： | 1 |
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