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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | N-acetylcysteine treats intravenous amiodarone induced liver injury显示文摘We report a case of intravenous(IV) amiodarone drug induced liver injury(DILI).The patient received IV N-acetylcysteine(NAC) which resulted in a rapid improvement in liver enzymes.While the specific mechanisms for the pathogenesis of IV amiodaroneDILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality.Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases. | Matthew L Mudalel Kartikeya P Dave James P Hummel Steven F Solga | 2015 | World Journal of Gastroenterology2015，21，9： | 5 |
| 3 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 4 | Soil moisture: A central and unifying theme in physical geography显示文摘 | Legates David R Mahmood Rezaul Levia Delphis F DeLiberty Tracy L Quiring Steven M Houser Chris Nelson Frederick E | 2011 | Progress in Physical Geography2011，，1： | 2 |
| 5 | Heavy metal assessment for surface sediments fromthree areas of the Portuguese continental shelf 显示文摘 | Mil-Homens M Stevens R L Abrantes F | 2006 | Continental Shelf Research2006，26，10： | 1 |
| 6 | Prenylfavonoids from Humulus lupulus 显示文摘 | Stevens J F Ivancic M Hsu V L | 1997 | Phytochemistry1997，44，8： | 1 |
| 7 | Heavy metal assessment for surface sediments from three areas of the Portuguese continental shelf 显示文摘 | Mil-Homens M Stevens R L Abrantesa F | 2006 | Continental Shelf Research2006，26，： | 1 |
| 8 | Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK During Apoptosis in Renal Epithelial Cells显示文摘 | van de WATER B NAGELKERKE J F STEVENS J L | 1999 | J Biol Chem1999，274，13： | 1 |
| 9 | Influence of alcohol on the processing of emotional facial expressions in individuals with social phobia显示文摘 | Stevens S Rist F Gerlach A L | 2009 | British Journal of Clinical Psychology2009，48，2： | 1 |
| 10 | Screening two Lycopersicon peruvianum collections for resistance to Tomato spotted wilt virus 显示文摘 | Gerdillo L F Stevens M R Millard M A | 2008 | Plant Disease2008，92，： | 1 |
| 11 | Identification of isoflavonesin the roots of pueraria lobata显示文摘 | Rong Haojing Stevens J F Deinzeretal M L | 1998 | Planta Medica1998，64，： | 1 |
| 12 | Effect of stacking sequence on micro-cracking in a cryogenically cycled carbon/ bismaleimide composite 显示文摘 | Bethel V T Mark B F Steven L D | 2003 | Composites: Part A2003，34，7： | 1 |
| 13 | Identification of isoflavones in the roots of Pueraria lobata 显示文摘 | Haojing Rong Jan F Stevens Max L Deinzer | 1998 | Planta Med1998，64，： | 1 |
| 14 | Deterrents extracted from the leaves of Ginkgo biloba:effects on feeding and contact chemoreceptors显示文摘 | Yang F S Evans K A Stevens L H | 1990 | Entomol exp appl1990，54，： | 1 |
| 15 | Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells显示文摘 | Miranda C L Aponso G L Stevens J F | 2000 | Cancer Lett2000，149，1： | 1 |
| 16 | Prenylflavonoids from Humulus luPulus显示文摘 | Jan F Stevens Monika Ivancic Victor L Hsu | 1997 | Phytochemistry1997，44，8： | 1 |
| 17 | Copyright Protection for the Electronic Distribution of Text Documents显示文摘 | Jack T B Steven L Nicholas F M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 18 | Modu-lation of macrophage and B cell function by glycosaminoglycans显示文摘 | WRENSHALL L E STEVENS R B CERRA F B | 1999 | J Leukoc Biol1999，66，3： | 1 |
| 19 | Chemistry and biology of hop flavonoids显示文摘 | Jan F Stevens Cristobal L Miranda Donald R Buhler | 1998 | J Am Soc Brew Chem1998，，56： | 1 |
| 20 | Heavy metal assessment for surface sediments from three areas of the Portuguese continental shelf显示文摘 | Mil-Homensa M Stevens R L Abrantes F Cato I | 2006 | Continental Shelf Research2006，26，： | 1 |
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