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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | Contour integration in the peripheral field显示文摘 | Hess R F Steven C D | 1999 | Vision Research1999，39，5： | 1 |
| 4 | Floral dip:a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana显示文摘 | Steven J C Andrew F B | 1998 | Plant J1998，16，6： | 1 |
| 5 | Pericentral Hepatic Fibrosis and Intracellular Hyalin in Diabetes Mellitus显示文摘 | Kenneth R F alchuk Steven C | 1980 | Gastroente rology1980，78，： | 1 |
| 6 | Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons 显示文摘 | Song H J Stevens C F Gage F H | 2002 | Nat Neurosci2002，5，5： | 1 |
| 7 | Development of a vibrating cassava root harvester显示文摘 | Gupta C P Stevens W F Paul S C | 1999 | Agricultural Mechanization in Asia Africa and Latin America1999，30，1： | 1 |
| 8 | Potential beneficial metabolic interactions between tamoxifen and isoflavones via cytochrome P450-mediated pathways in female rat liver microsomes显示文摘 | Chen J Steven C H Joshua F A | 2004 | Pharm Res2004，21，11： | 1 |
| 9 | Acceleration of the discrete element method (DEM) on a reconfigurable co-processor 显示文摘 | BENJAMIN C S STEVEN F Q ANDREW H C C | 2004 | Computers and Structures2004，82，2021： | 1 |
| 10 | A Simple Method for Calibra- ting Force Plates and Force Treadmills Using an Instrumented Pole 显示文摘 | Steven H C Peter G A Daniel P F | 2009 | Gait and Posture2009，29，： | 1 |
| 11 | Inheritance of the waist-to-hip ratio in the national heart, lung, and blood institute family heart study 显示文摘 | FEITOSA M F BORECKI I STEVEN C | 2000 | Obesity Research2000，8，： | 1 |
| 12 | Astroglia induce neurogenesis from adult neural stem cells 显示文摘 | Song H Stevens C F Gage F H | 2002 | Nature2002，417，6884： | 1 |
| 13 | Solid nanoparticles that catalyze biofuel upgrade reactions at the water/oil interface 显示文摘 | STEVEN C JIMMY F MIN S | 2010 | Science2010，327，5961： | 1 |
| 14 | Decomposition and ignition of the high-nitrogen compound triamino-guanidinium azotetrazolate(TAGZT)显示文摘 | Bryce C T Arif N A Steven F S et al | 2006 | Propellants Explosives Pyrotechnics2006，31，3： | 1 |
| 15 | Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells显示文摘 | Miranda C L Aponso G L Stevens J F | 2000 | Cancer Lett2000，149，1： | 1 |
| 16 | Disaggregat- ing census data for population mapping using random for- ests with remotely-sensed and ancillary data显示文摘 | Stevens F R Gaughan A E Linard C | 2015 | PLoS ONE2015，10，10： | 1 |
| 17 | Mechanical strain increases force production and calcium sensitivity in culturet airway smooth muscle cells显示文摘 | Smith PG Roy C Steven F | 2000 | J Appl Physiol2000，89，5： | 1 |
| 18 | The carbon isotopic composition of atmospheric methane显示文摘 | Stevens C M Rust F E | 1982 | Journal of Geophysical Reasearch1982，87，： | 1 |
| 19 | Crystal size distribution in continuous crystallizer when growth rate is size-dependent 显示文摘 | Abegg C F Stevens J D Larson M A | 1968 | AIChE J1968，14，： | 1 |
| 20 | Prediction of repetitive firing behaviourfrom voltage clamp data on an isolated neurone soma 显示文摘 | Connor J A Stevens C F | 1971 | Physiol1971，213，1： | 1 |
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