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您的检索式：作者名="Steve Caplan"
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| 1 | Important relationships between Rab and MICAL proteins in endocytic trafficking显示文摘The internalization of essential nutrients,lipids and receptors is a crucial process for all eukaryotic cells.Accordingly,endocytosis is highly conserved across cell types and species.Once internalized,small cargocontaining vesicles fuse with early endosomes(also known as sorting endosomes),where they undergo segregation to distinct membrane regions and are sorted and transported on through the endocytic pathway.Although the mechanisms that regulate this sorting are still poorly understood,some receptors are directed to late endosomes and lysosomes for degradation,whereas other receptors are recycled back to the plasma membrane;either directly or through recycling endosomes.The Rab family of small GTP-binding proteins plays crucial roles in regulating these trafficking pathways.Rabs cycle from inactive GDP-bound cytoplasmic proteins to active GTP-bound membraneassociated proteins,as a consequence of the activity of multiple specific GTPase-activating proteins(GAPs) and GTP exchange factors(GEFs).Once bound to GTP,Rabs interact with a multitude of effector proteins that carry out Rab-specific functions.Recent studies have shown that some of these effectors are also interaction partners for the C-terminal Eps15 homology(EHD) proteins,which are also intimately involved in endocytic regulation.A particularly interesting example of common Rab-EHD interaction partners is the MICALlike protein,MICAL-L1.MICAL-L1 and its homolog,MICAL-L2,belong to the larger MICAL family of proteins,and both have been directly implicated in regulating endocytic recycling of cell surface receptors and junctional proteins,as well as controlling cytoskeletal rearrangement and neurite outgrowth.In this review,we summarize the functional roles of MICAL and Rab proteins,and focus on the significance of their interactions and the implications for endocytic transport. | Juliati Rahajeng Sai Srinivas Panapakkam Giridharan Naava Naslavsky Steve Caplan | 2010 | World Journal of Biological Chemistry2010，1，8： | 2 |
| 2 | Diffusion- and Perfusion-Weighted MRI Patterns in Borderzone Infarcts显示文摘 | Claudia J. Chaves Brian Silver Gottfried Schlaug John Dashe Louis R. Caplan Steve Warach | 2000 | Stroke: Journal of the American Heart Association2000，，5： | 1 |
| 3 | Diffusion- and Perfusion-Weighted MRI Patterns in Borderzone Infarcts显示文摘 | Claudia J. Chaves Brian Silver Gottfried Schlaug John Dashe Louis R. Caplan Steve Warach | 2000 | Stroke: Journal of the American Heart Association2000，，5： | 1 |
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