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| 1 | 光动力疗法治疗尿道尖锐湿疣的临床研究显示文摘目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗尿道尖锐湿疣的最适ALA浓度和最佳敷药时间。方法将60例尿道尖锐湿疣患者分为0.5%、1%、3%、5%和10%ALA五组,分别在敷药1、3、5、7h时取材,进行原位定量原卟啉Ⅸ检测、常规组织病理检查和杂交捕获试验检测高危型、低危型HPV DNA。结果经不同浓度和时间的ALA湿敷后,皮损局部的表皮内均有不同程度的原卟啉Ⅸ砖红色荧光,荧光基本上分布于表皮全层,而真皮几乎见不到原卟啉Ⅸ荧光。原位定量原卟啉Ⅸ荧光强度在敷药3h时已经明显升高,在5h时到达最高峰,7h时再次下降为3h时的水平。随着ALA浓度的增高,其组织中原卟啉Ⅸ的荧光强度逐渐增高。经统计学分析,5%和10%ALA组原卟啉Ⅸ荧光强度显著高于其他组(P<0.05)。HPV DNA杂交捕获试验结果显示,尿道尖锐湿疣患者的临床标本中低危型HPV DNA 100% (60/60)阳性,18.3%(11/60)病例同时检测出高危型HPV DNA。结论ALA-PDT治疗尿道尖锐湿疣的最佳ALA浓度为5%或10%,最佳敷药时间为3-5h。 | 王秀丽 王宏伟 过明霞 Herbert Stepp Reinhold Baumgartner | 2006 | 中华皮肤科杂志2006，39，12： | 43 |
| 2 | Effects of Different Levels of Water Stress on Leaf Water Potential,Stomatal Resistance,Protein and Chlorophyll Content and Certain Anti-oxidative Enzymes in Tomato Plants显示文摘一个温室实验被执行以便调查叶水位(PSI_W ) 上的应力,有气孔的抵抗(r_s ) ,蛋白质内容和叶绿素(迟) 番茄满足的水的不同层次的效果(Lycopersicon 可食用的瓮米尔。cv.Nikita ) 。水应力被增加聚乙二醇导致(木钉 6 000 ) 到到还原剂的营养液渗透的潜力(PSI_s ) 。我们调查了抗氧化剂酶的行为,例如过氧化氢酶(猫) 和超级氧化物 dismutase (草皮) ,在水应力的发展期间。Moderateand 严重的水应力(即 PSI_S=-0.51 和 -1.22 MPa,分别地) 在都对待的 PSI_Wfor 引起了减少(强调水) 与控制植物相比种,与减小,更多为严重地强调的植物正在被读。另外, r_s 被导致的水压力和减少显著地在叶可溶性蛋白质影响,迟内容被观察。而 CATactivity 仍然保持不变,草皮活动与不着重的植物相比在强调水的植物被增加。当为在水下面的植物的一个抗氧化剂保护者系统强调条件,这些结果显示草皮的可能的角色。而且,当为检测的一个另外的屏蔽标准在植物浇应力,它建议使用这酶的可能性。 | Hatem Zgalla Kathy Steppe Raoul Lemeur | 2006 | Journal of Integrative Plant Biology2006，48，6： | 22 |
| 3 | 5-氨基酮戊酸光动力疗法治疗寻常痤疮临床应用研究显示文摘目的探索5-氨基酮戊酸光动力疗法(ALA—PDT)治疗寻常痤疮的ALA最适浓度和最佳敷药时间。方法将30例中、重度寻常痤疮患者随机分为两组,第一组15例,给以10%ALA乳膏外敷,分别在不同时间点(1、2、3、4、5h)和不同皮损进行原卟啉IX(PpIX)荧光光动力诊断和皮损组织PpIX荧光采集与定量分析;第二组15例,在每例患者的右侧面颊、左侧面颊、前额的痤疮皮损上分别给以3%、5%、10%ALA乳膏外敷3h后进行PpIX荧光光动力诊断和荧光定量研究;同时对该组患者不同部位采用不同浓度ALA—PDT的疗效和不良反应进行临床研究。结果第一组痤疮患者经10%ALA乳膏外敷,暗室环境下采用激发光源照射皮损后发现,炎性丘疹、脓疱和囊肿均显示PpIX强砖红色荧光;粉刺、炎性丘疹、脓疱和囊肿的PpIX荧光强度分别为1.3、4.3,5.1和5.8校准单位,PpIX荧光强度随着皮损严重程度的增加而增强;同时,随着外敷时间的延长,PpIX荧光强度逐渐增强,敷药3h、4h、5h时PpIX荧光强度明显高于1h和2h(P〈0.05)。第二组患者不同部位采用3%、5%、10%ALA封包3h,其相同皮损内PpIX荧光强度差异无统计学意义(P〉0.05);分别以3%、5%、10%ALA乳膏外涂于15例患者右侧面颊、左侧面颊、前额部位,经过两次ALA—PDT治疗后,痊愈5例、显效6例,总有效率为73%;每例患者的不同部位皮损之间,疗效改善情况无明显差异。副作用表现为轻至中度的红斑、肿胀,严重时少许渗出,仅2例出现暂时陛色素沉着,所有病例均未出现溃疡和瘢痕等严重不良反应。结论ALA—PDT适用于以炎性丘疹、脓疱和囊肿为主要表现的寻常痤疮治疗,宜采用3%ALA浓度和3h敷药时间。 | 王秀丽 王宏伟 苏丽娜 张玲琳 过明霞 Herbert Stepp | 2009 | 中华皮肤科杂志2009，42，8： | 16 |
| 4 | 罗东(台湾)土—结构相互作用大比例模型试验的启示(Ⅰ)显示文摘地震反应预测结果评估——逐个方法评估评估地震反应结果的基本方法,是将结构预先选定点上的阻尼比为5%的加速度反应谱与其记录反应谱进行对比。虽然报告提到了好几个点的反应。 | A. H. Hadjian W. S. Tseng C. Y. Chang D. Anderson N. C. Tsai Y. K. Tang H. T. Tang J. C. Stepp 谢君斐 | 1993 | 世界地震工程1993，9，3： | 9 |
| 5 | Photosynthetic, Physiological and Biochemical Responses of Tomato Plants to Polyethylene Glycol-Induced Water Deficit显示文摘Polyethylene glycol (PEG 6000)-induced water deficit causes physiological as well as biochemical changes in plants. The present study reports on the results of such changes in hydroponically grown tomato plants (Lycopersicon esculentum Mill. cv. Nikita). Plants were subjected to moderate and severe levels of water stress (i.e. water potentials in the nutrient solution of-0.51 and -1.22 MPa, respectively).Water stress markedly affected the parameters of gas exchange. Net photosynthetic rate (Pn) decreased with the induction of water stress. Accordingly, a decrease in the transpiration rate (E) was observed. The ratio of both (Pn/E) resulted in a decrease in water use efficiency. One of the possible reasons for the reduction in Pn is structural damage to the thylakoids, which affects the photosynthetic transport of electrons. This was indicated by an increase in non-photochemical quenching and a reduction in the quantum yield of photosystem Ⅱ. Furthermore, a decrease in both leaf water potential and leaf osmotic potential was observed, which resulted in a significant osmotic adjustment during stress conditions. Analysis of the physiological responses was complemented with a study on changes in proline content. In stressed plants, a 10-fold increase in proline content was detected compared with control plants. It is clear that water stress tolerance is the result of a cumulative action of various physiological and biochemical processes, all of which were affected by PEG 6000-induced water stress. | Hatem ZGALLAI Kathy STEPPE Raoul LEMEUR | 2005 | Journal of Integrative Plant Biology2005，47，12： | 6 |
| 6 | Monolithic LC method applied to fesoterodine fumarate low dose extended-release tablets:Dissolution and release kinetics显示文摘A dissolution test for fesoterodine low dose extended-release tablets using liquid chromatographic(LC) method equipped with a C18 monolithic column was developed and validated. LC system was operated isocratically at controlled temperature(40 1C) using a mobile phase of acetonitrile:methanol:0.03 M ammonium acetate(p H 3.8)(30:15:55, v/v/v), run at a flow rate of 1.5 m L/min and detected at 208 nm. The best dissolution conditions for this formulation were achieved using a USP apparatus 2(paddle) at 100 rpm and 900 m L of phosphate buffer at p H 6.8 as the dissolution medium.Validation parameters such as the specificity, linearity, accuracy, precision, and robustness were evaluated according to international guidelines, giving results within the acceptable range. The kinetic parameters of drug release were also investigated using model-dependent methods and the dissolution profiles were best described by the Higuchi model. The validated dissolution test can be applied for quality control of this formulation. | Maximiliano S.Sangoi Vítor Todeschini Martin Steppe | 2015 | Journal of Pharmaceutical Analysis2015，5，2： | 2 |
| 7 | Perforin gene defects in familial hemophagocytic lymphohisticeytosis 显示文摘 | Stepp S E Dufourcq-Lagelouse R Le Deist F | 1999 | Science1999，286，： | 1 |
| 8 | Fluorescence cystoscopy following intravesical instillation of 5-aminolevulinic acid:a new procedure with high sensitivity for detection of hardly visible urothelial neoplasias显示文摘 | Kriegmair M Stepp H Steinbach P | 1995 | Urol Int1995，55，4： | 1 |
| 9 | Fluorescenceguided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins:a prospective study in 52 consecutive patients 显示文摘 | Stummer W Novotny A Stepp H | 2000 | J Neurosurg2000，93，： | 1 |
| 10 | Photodynamic Diagnosis in Urology: State-of-the-Art 显示文摘 | Dieter Jocham Herbert Stepp Raphaela Waidelich | 2007 | European Urology2007，，6： | 1 |
| 11 | Perforin gene defects in familial hemophagocytic lymphohistiocytosis显示文摘 | Stepp S E | 1999 | Science1999，286，： | 1 |
| 12 | Oedema formation in experimental photo-irradiation therapy of brain tumours using 5-ALA显示文摘 | Ito S Rachinger W Stepp H | 2005 | Acta Neurochir2005，147，1： | 1 |
| 13 | Effects of nitro- gen deficiency on leaf photosynthesis, carbohydrate sta- tus and biomass production in two olive cultivars ' Mes- ki' and ' Koroneiki' 显示文摘 | Boussadia O Steppe K Zgallai H | 2010 | Scientia Horticuhurae2010，123，： | 1 |
| 14 | The integrin family of cell surface receptors显示文摘 | De Simone DW Stepp MA Patel RS | 1987 | Biochem Soc Trans1987，15，5： | 1 |
| 15 | Fluorescence-guided re- section of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients显示文摘 | Stummer W Novotny A Stepp H | 2000 | J Neurosurg2000，93，6： | 1 |
| 16 | Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate显示文摘 | Soergel P Wang X Stepp H | 2008 | Lasers Surg Med2008，40，： | 1 |
| 17 | Learning from observation:Conceptual clustering 显示文摘 | MICHAISKI R S STEPP R E | 1983 | Machine Learning:An artificial Intelligence Approaches1983，，： | 1 |
| 18 | Stem respiration and carbon dioxide efflux of young Populus deltoides trees in relation to temper- ature and xylem carbon dioxide concentration 显示文摘 | Saveyn A Steppe K McGuire M A | 2008 | Oecologia2008，154，4： | 1 |
| 19 | Use of X-ray computed Microto- mography for Non-invasive Determination of Wood Anatomical Characteristics显示文摘 | Steppe K Cnudde V Girard C | 2004 | Journal of Structural Biology2004，148，1： | 1 |
| 20 | Comparisons of EEG sleep-specific spectral values between healthy full-term and preterm infants at comparable postconceptional ages显示文摘 | Scher MS Sun M Steppe DA | 1994 | Sleep1994，，： | 1 |
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