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| 1 | Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study显示文摘BACKGROUND Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder. Dysregulation of the gut–brain axis plays a central role in the pathophysiology of IBS. It is increasingly clear that the microbiome plays a key role in the development and normal functioning of the gut–brain axis.AIM To facilitate the identification of specific areas of focus that may be of relevance to future research. This study represents a bibliometric analysis of the literature pertaining to the microbiome in IBS to understand the development of this field.METHODS The data used in our bibliometric analysis were retrieved from the Scopus database. The terms related to IBS and microbiome were searched in titles or abstracts within the period of 2000–2019. VOSviewer software was used for data visualization.RESULTS A total of 13055 documents related to IBS were retrieved at the global level. There were 1872 scientific publications focused on the microbiome in IBS. There was a strong positive correlation between publication productivity related to IBS in all fields and productivity related to the microbiome in IBS(r = 0.951, P < 0.001). The United States was the most prolific country with 449(24%) publications, followed by the United Kingdom(n = 176, 9.4%), China(n = 154, 8.2%), and Italy(n = 151, 8.1%). The h-index for all retrieved publications related to the microbiome in IBS was 138. The hot topics were stratified into four clusters:(1) The gut–brain axis related to IBS;(2) Clinical trials related to IBS and the microbiome;(3) Drugmediated manipulation of the gut microbiome;and(4) The role of the altered composition of intestinal microbiota in IBS prevention.CONCLUSION This is the first study to evaluate and quantify global research productivity pertaining to the microbiome in IBS. The number of publications regarding the gut microbiota in IBS has continuously grown since 2013. This finding suggests that the future outlook for interventions targeting the gut microbiota in IBS remains promising. | Sa'ed H Zyoud Simon Smale W Stephen Waring Waleed Sweileh Samah W Al-Jabi | 2021 | World Journal of Gastroenterology2021，27，13： | 2 |
| 2 | Assessment of the multiple-biomarker app roach for diagnosis of myocardial infarction in patients presenting with symptoms suggestive of acute coronary syndrome显示文摘 | Fred SA Stephen WS Lesly AP | 2009 | Clin Chem2009，55，： | 1 |
| 3 | Chemotherapy-related hepatotoxicity causing imaging findings resembling cirrhosis显示文摘 | Schreiner SA Gorman B Stephens DH | 1998 | Mayo Clin Proc1998，73，： | 1 |
| 4 | Co-stimulation and modulation of the ensuing immune response 显示文摘 | Howard C J Hope JC Stephens SA | 2002 | Vet Immunol Immunopathol2002，87，34： | 1 |
| 5 | Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury显示文摘 | Stephen A Back SA Luo NL | 2001 | Neuroscience2001，21，： | 1 |
| 6 | Symptoms of acute cor- onary syndrome in women with diabetes:An integrative review of the literature显示文摘 | Stephen SA Darney BG Rosenfeld AG | 2008 | Heart Lung2008，37，： | 1 |
| 7 | Costimulation and modulation of the ensuing immune response 显示文摘 | Howard C J Hope JC Stephens SA | 2002 | Vet Immunol Immunopathol2002，87，34： | 1 |
| 8 | New Gene Variants Associated with the Risk of Chronic HBV Infection显示文摘Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to HBV.Here we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of HBV.The first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence coverage.Adapters,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome hg19.In the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first stage.Although there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined analysis.One association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection. | Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova Stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng | 2020 | Virologica Sinica2020，35，4： | 1 |
| 9 | Facial nerve tumors and progressive facial palsy 显示文摘 | SCHEECK SA LEFF HI STEPHENS JW | 1960 | Arch Neurology1960，2，4： | 1 |
| 10 | A microtubule - binding domain in dynactin in- creases dynein processivity by skating along microtubules 显示文摘 | TL Culver Hanlon SA Lex AD Stephens | 2006 | Nature cell2006，，2： | 1 |
| 11 | Fatigue in older adults with stable heart failure显示文摘 | Stephen SA | 2008 | Heart Lung2008，37，1： | 1 |
| 12 | Co-stimulation and moclulation of the ensuing immune response 显示文摘 | Howard CJ Hope JC Stephens SA | 2002 | Vet Immunol Immunopathol2002，87，34： | 1 |
| 13 | A review of allochthonous organic matter dynamics and metabolism in streams 显示文摘 | Tank JL Rosi-Marshall EJ Griffiths NA Entrekin SA Stephen ML | 2010 | N Am Benthol Soc2010，29，1： | 1 |
| 14 | Labeling and distribution of linear peptides identified using in vivo phage display selection for tumors显示文摘 | Mirzadeh Saed Hurst Gregory B | 2000 | Nucl Med Biol2000，27，8： | 1 |
| 15 | Robot-assisted laparoscopic ureterolysis:case report and literature review of the minimally invasive surgical approach显示文摘 | Seixas-Mikelus SA Marshall SJ Stephens DD | | 0，，： | 1 |
| 16 | Development of an anti-Salmonella typhi Vi ELISA:assessment of immunocompetence in healthy donors显示文摘 | Ferry BL Misbah SA Stephens P | 2004 | Clin Exp Immunol2004，136，2： | 1 |
| 17 | Relationship be- tween polysomnographic sleep architecture and behavior in medieation-fi'ee children with TS, ADHD, TS and ADHD, and controls 显示文摘 | Stephens RJ Chung SA Jovanovic D | 2013 | J Dev Behav Pediatr2013，34，9： | 1 |
| 18 | Assessment of the multiple-biomarker approach for diagnosis of myocardial infarction in patients presenting with symptoms suggestive of acute coronary syndrome显示文摘 | Fred SA Stephen WS Lesly AP | | 0，，01： | 1 |
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