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| 1 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 2 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 3 | Enhanced removal of organic matter and ammaniacal-nitrogen in a column experiment of tidal flow constructed wetland system 显示文摘 | Sun G Z Zhao Y Q Stephen Allen | 2005 | Journal of Biotechnology2005，115，2： | 1 |
| 4 | Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123显示文摘 | Stephen L Hempel Garry R Buettner Yunxia Q O’Malley Duane A Wessels Dawn M Flaherty | 1999 | Free Radical Biology and Medicine1999，，1： | 1 |
| 5 | Enhanced removal of organic matter and ammoniacal-nitrogen in a column experiment of tidal flow constructed wetland system 显示文摘 | SUN G Z ZI-IAO Y Q STEPHEN ALLEN | 2005 | Journal of Biotechnology2005，，： | 1 |
| 6 | From micro- to nanofabrication with soft materials显示文摘 | STEPHEN R Q AXEL S | 2000 | Science2000，290，24： | 1 |
| 7 | Enhanced removal of organic matter and ammoniacal-nitrogen in a column experiment of tidal flow constructed wetland system 显示文摘 | SUN G Z ZHAO Y Q STEPHEN A | 2005 | Journal of Biotechnology2005，115，2： | 1 |
| 8 | Duality-based algo- rithms for total variation regularized image restoration 显示文摘 | Zhu M Q Wright Stephen J Chan Tony F | 2010 | Com- putational Optimization and Applications2010，47，3： | 1 |
| 9 | Accuracy of drug infusion pump under computer control显示文摘 | STEPHEN B C TIMOTHY J Q JAMES R J | 1992 | IEEE Transactions on Biomedical Engineering1992，39，9： | 1 |
| 10 | 显示文摘 | William J Koros Stephen J Miller | 2003 | Journal of Membrane Science2003，，211： | 1 |
| 11 | Do starting and ending effects in fixed-price group-buying differ?显示文摘 | Zhou G Xu K Q Stephen S Y | 2013 | Electronic Commerce Research and Applications2013，12，2： | 1 |
| 12 | Thermoelectric properties of pressed bismuth nanoparticles显示文摘 | STEPHEN R H YU Q MICHAEL T | 2008 | Superlattices Microstruct2008，43，： | 1 |
| 13 | An air-soil layer coupled scheme for computing surface heat fluxes显示文摘 | XU Q ZHOU B B STEPHEN D | 1999 | Journal of Applied Meteorology1999，38，2： | 1 |
| 14 | Detection of wood decay in blue gum and elm:an evaluation of the resitograph and the portable drill显示文摘 | Laurence R C Stephen L Q | 1999 | Jounal of Arboriculture1999，25，6： | 1 |
| 15 | Cigarettes sold in China: design, emissions and metals显示文摘 | O'Connor R J Li Q Stephens W E | 2010 | Tobacco Control2010，19，： | 1 |
| 16 | Social and geographic distance in HIV risk显示文摘 | Richard Rothenberg Stephen Q Muth | 2005 | Sexually Transmitted Diseases2005，32，8： | 1 |
| 17 | Recurring patterns of total organic carbon and source rock quality within a sequence stratigraphic framework显示文摘 | Stephen Creaney and Passey Q R | 1993 | AAPG Bulletin1993，77，3： | 1 |
| 18 | Cigarettes sold in China:design,emissions and metals显示文摘 | RICHARD J O LI Q STEPHENS W E | 2010 | Tobacco Control2010，19，2： | 1 |
| 19 | Integration of inventory and transportation decisions in a logistics system 显示文摘 | Zhao Q H Chen S Stephen C H | 2010 | Transportation Research Part E2010，46，6： | 1 |
| 20 | Summertime heat island intensities in three high-rise housing quarters in inner-city Shanghai China: Building layout, density and greenery 显示文摘 | Feng Y Stephen S Y L Feng Q | 2010 | Building and Environment2010，45，： | 1 |
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