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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Effect of recombinant human osteogenic protein - 1 on healing of segmental defects in non-human primate显示文摘 | Stephen DC Michael WW Samantha LS | 1995 | J Bone Joint Surg (AM)1995，77，： | 1 |
| 3 | Epilepsy in elderly people 显示文摘 | Stephen LS Brodie MJ | 2000 | Lancet2000，355，9213： | 1 |
| 4 | Epilepsy in elderly people 显示文摘 | Stephen LS Brodie MJ | 2000 | Lancet2000，355，12： | 1 |
| 5 | Extracerebral cavernous hemangioma of the cavernous sinus: diagnosis with MR imaging and labeled red cellblood pool scintigraphy 显示文摘 | Giovanni CS Stephen LS Michae 1M | 2004 | Am J Neuroradiol2004，25，： | 1 |
| 6 | Identification,immu-nomodulatory activity and immunogenicity of the major helper T cell epitope on the K blood group antigen显示文摘 | Stephen J Cairns LS Pickford WJ | | 0，，23： | 1 |
| 7 | Effect of recombinant human osteogenie protein 1 on healing of segmental defects in non human primate 显示文摘 | Stephen DC Michael WW Samantha LS | 1995 | J Bone Joint Surg(Am)1995，77，5： | 1 |
| 8 | Plasma renin activity pre- dicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension显示文摘 | Stephen TT Gary LS Arlene BC | 2010 | Am J Hypertens2010，23，9： | 1 |
| 9 | Extracerebral cavernous hemangioma of the cavernous sinus:diagnosis with MR imaging and labeled red cellblood pool scintigraphy显示文摘 | GiovanniCS Stephen LS MichaelM | 2004 | Am JNeuroradiol2004，25，2： | 1 |
| 10 | Comparison of the safety of early enteral VS parenteral nutrition in mild acute pancreatitis显示文摘 | Stephen AM Lisa MG Harvy LS etal | 1997 | JPEN1997，21，1： | 1 |
| 11 | Neuropsychological effects of long-term exposure to or- ganophosphates in sheep dip 显示文摘 | Stephens R Spurgeon A Calvert IA Beach J Levy LS Berry H | 1995 | Lancet1995，345，8958： | 1 |
| 12 | Extracerebral cavernous hemangioma of the cavernous sinus: diagnosis with MR imaging and labeled red ceUblood pool scintigraphy 显示文摘 | Giovanni CS Stephen LS Michae IM | 2004 | Am J Neuroradiol2004，25，： | 1 |
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