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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Temporal patterns of radiographic infiltration in severely traumatized patients with and without adult respiratory distress syndrome显示文摘 | Johnson KS Bishop MH Stephen CM | 1994 | J Trauma1994，36，5： | 1 |
| 3 | Neurodevelopmental impairment:predictors of its impact on the families of extremely low birth weight infants at 18 months显示文摘 | Stephens BE Bann CM Poole WK | | 0，，： | 1 |
| 4 | Cranioplasty compli- cations following wartime decompressive craniectomy 显示文摘 | Stephens FL Mossop CM Bell RS | 2010 | Neurosurg Focus2010，28，5： | 1 |
| 5 | Food safety hazards associated with consumption of raw milk显示文摘 | Stephen PO Kathryn JB Steven CM | 2009 | Food- borne Pathogens and Disease2009，6，7： | 1 |
| 6 | Temporal patterns of radiographic in severely traumatized patients with and without adult respiratory distress syndryme 显示文摘 | Johnson KS Bbhop MH Stephen CM | 1994 | Trauma1994，36，： | 1 |
| 7 | Early Intervention in Low Birth Weight Premature Infants:Results at 18 Years of Age for the Infant Health and Development Program显示文摘 | Marie CM Jeanne BG Stephen L | 2006 | Pediatrics2006，117，3： | 1 |
| 8 | Temporal patterns of radiographic infiltration in severely traumatized patients with and without adult respiratory distress syndrome显示文摘 | Johnson KS Bishop Stephen CM | 1994 | J Trauma1994，36，： | 1 |
| 9 | Mismatch repair protein expression 1049 endometrial carcinomas, association With body mass index,and other clinicopathologic variables 显示文摘 | Joehlin-Price AS Perrino CM stephens J | 2014 | Gynecol Oncol2014，133，1： | 1 |
| 10 | Temporal patterns of radiographic infiltration in severely traumatized patients with and without adult respiratory distress syndrome显示文摘 | Johnson KS Bishop Stephen CM | 1994 | J Trauma1994，36，5： | 1 |
| 11 | Acute fructose administration improves Oral glucose tolerance in adults with type 2 diabetes显示文摘 | Mary CM Stephen ND Stephanie LM | 2001 | Diabetes Care2001，24，11： | 1 |
| 12 | Unique microRNA molecular profiles in tung cancer diagnosis and prognosis显示文摘 | Yanaihara N Caplen N Bowman E Seike M Kumamoto K Yi M Stephens RM Okamoto A Yokota J Tanaka T Calin GA Liu CG Croce CM Harris CC | 2006 | Cancer Cell2006，9，3： | 1 |
| 13 | Cranioplasty complications following wartime decompressive craniectomy 显示文摘 | Stephens FL Mossop CM Bell RS | 2010 | Neurosurg Focus2010，28，5： | 1 |
| 14 | Temporal patterns of radiographic infiltration in severely traumatized patients with and without adult respiratory distress syndrome显示文摘 | Johnson KS Bishop Stephen CM | 1994 | J Trauma1994，36，5： | 1 |
| 15 | Effect of two intensive sta-tin regimens on progression of coronary disease 显示文摘 | Stephen JN Ballantyne CM Barter PJ | 2011 | N Engl J Med2011，365，22： | 1 |
| 16 | Temporal pattems of radiographic infiltration in severely traumatized patients with and without adult respiratory distress syndrome显示文摘 | Johnson KS Bishop MH Stephen CM | 1994 | J Trauma1994，36，5： | 1 |
| 17 | Impact of hypertension and apolipoprotein E4 on poststroke cognition in subjects>75 years of age显示文摘 | Rowan E Morris CM Stephens S | 2005 | Stroke2005，36，： | 1 |
| 18 | Differential effect of environmental adversity by gender: Rutter's index of adversity in a group of boys and girls with and without ADHD显示文摘 | Joseph B Stephen VF Michael CM | 2002 | Am J Psychiatry2002，158，： | 1 |
| 19 | Targeting the unfolded protein response,XBP1,and the NLRP3 inflammasome in fibrosis and cancer显示文摘 | Overley-Adamson B Artlett CM Stephens C | 2014 | Cancer Biol Ther2014，15，4： | 1 |
| 20 | Usefulness of QRS duration in the absence of bundle branch block as an early predictor of survival in non-ST elevation acute myocardial infarction显示文摘 | Emmanouil SB Nikolaos CM Stephen LK | 2002 | Am J Cardiol2002，89，： | 1 |
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