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| 1 | Disease Progression, Response to ACEI/ATRA Therapy and Influence of ACE Gene in IgA Nephritis显示文摘Various studies have shown that angiotensin-converting enzyme (ACE) gene insertion/deletion (ID) polymorphism may play a role in the progression to end stage renal failure (ESRF) in patients with IgA nephritis (IgAN). In this randomized controlled trial, patients were followed up for 5 years to determine their long-term renal outcome to ACEI/ATRA therapy and to ascertain if their ACE gene profile could play a role in determining their response to therapy. Seventy-five patients with IgAN were enlisted. Thirty-seven were on ACEI/ATRA therapy for 62 ± 5 months and thirty-eight were untreated and served as controls. All patients had their ACE gene ID polymorphism genotyped. Compared to controls, treated patients had lower serum creatinine (p < 0.001), lower proteinuria (p < 0.002) and fewer numbers progressing to ESRF (p < 0.002). Among patients with genotype II, there were less ESRF in the treatment group when compared to the untreated control group (p < 0.02). The advantage of therapy was not seen in patients with ID or DD genotypes. ACEI/ATRA therapy was found to be effective in retarding disease progression in IgAN with years to ESRF significantly extended in patients at all levels of renal function, including patients whose outcome were ESRF. Genotyping showed better response to therapy only for those with genotype II. The common mechanism is probably through lower levels of ACE, glomerular pressure and proteinuria resulting in reduced renal damage and retardation of progression to ESRF. | Keng-Thye Woo Yeow-Kok Lau Yi Zhao Fang-E Liu Hwee-Boon Tan Eng-Keng Tan Fook-Chong Stephanie Choong-Meng Chan Kok-Seng Wong | 2007 | Cellular & Molecular Immunology2007，4，3： | 7 |
| 2 | Inverse-designed spinodoid metamaterials显示文摘After a decade of periodic truss-,plate-,and shell-based architectures having dominated the design of metamaterials,we introduce the non-periodic class of spinodoid topologies.Inspired by natural self-assembly processes,spinodoid metamaterials are a close approximation of microstructures observed during spinodal phase separation.Their theoretical parametrization is so intriguingly simple that one can bypass costly phase-field simulations and obtain a rich and seamlessly tunable property space.Counterintuitively,breaking with the periodicity of classical metamaterials is the enabling factor to the large property space and the ability to introduce seamless functional grading.We introduce an efficient and robust machine learning technique for the inverse design of(meta-)materials which,when applied to spinodoid topologies,enables us to generate uniform and functionally graded cellular mechanical metamaterials with tailored direction-dependent(anisotropic)stiffness and density.We specifically present biomimetic artificial bone architectures that not only reproduce the properties of trabecular bone accurately but also even geometrically resemble natural bone. | Siddhant Kumar Stephanie Tan Li Zheng Dennis M.Kochmann | 2020 | npj Computational Materials2020，，1： | 1 |
| 3 | Role of spinal inhibitory mechanisms in whiplash injuries显示文摘 | Lo YL Tan YE Stephanie FC | 2006 | J Neurotrauma2006，24，6： | 1 |
| 4 | A Novel Long-Range PCR Sequencing Method for Genetic Analysis of the Entire PKD1 Gene显示文摘 | Ying-Cai Tan Alber Michaeel Jon Blumenfeld Stephanie Donahue Tom Parker Daniel Levine Hanna Rennert | 2012 | The Journal of Molecular Diagnostics2012，，4： | 1 |
| 5 | Spoofing protection for fin- gerprint scanner by fusing ridge and valley noise显示文摘 | Bozhao Tan Stephanie Schuckers | 2010 | Pattern Recognition2010，43，8： | 1 |
| 6 | A retrospective Aliskiren and Losartan study in non-diabetic chronic kidney disease显示文摘AIM: To assess the efficacy of combined Aliskiren and Losartan vs high dose Losartan and Aliskiren alone in chronic kidney disease(CKD).METHODS: This is a retrospective study of 143 patients with non-diabetic CKD comparing combined Aliskiren(150 mg/d) with Losartan(100 mg/d) therapyvs High dose Angiotensin receptor blockers(ARB)(Losartan 200 mg/d) and the third group Aliskiren(150 mg/d) alone. This study involved only patient medical records. Entry criteria included those patients who had been treated with the above drugs for at least 36 mo within the 5 years period; other criteria included proteinuria of 1 g or more and or CKD Stage 3 at the start of the 36 mo period. The study utilised primary renal end points of estimated Glomerular Filtration Rate(e GFR) < 15 m L/min or end stage renal failure. RESULTS: Patients treated with high dose ARB compared to the other two treatment groups had significantly less proteinuria at the end of 36 mo(P < 0.007). All 3 groups had significant reduction of proteinuria(P < 0.043, P < 0.001). Total urinary protein was significantly different between the 3 groups over the 3-year study period(P = 0.008), but not e GFR. The changes in e GFR from baseline to each year were not significantly different between the 3 therapeutic groups(P < 0.119). There were no significant differences in the systolic and diastolic blood pressure between the 3 drug groups throughout the 3 years. The incidence of hyperkalemia(> 5.5 mmol/L) was 14.2%(7/49) in the Combined Aliskiren and ARB group, 8.7%(4/46) in the Aliskiren alone group and 6.3%(3/48) in the High dose ARB group(P < 0.001). CONCLUSION: This study in non-diabetic CKD patients showed that Combination therapy with Aliskiren and ARB was effective but was not safe as it was associated with a high prevalence of hyperkalaemia. | Keng-Thye Woo Hui-Lin Choong Kok-Seng Wong Han-Kim Tan Marjorie Foo Fook-Chong Stephanie Evan JC Lee Vathsala Anantharaman Grace SL Lee Choong-Meng Chan | 2013 | World Journal of Nephrology2013，2，4： | 1 |
| 7 | ALLERDB database and integrated bioinformatic tools for assessment of allergenicity and allergic cross-reactivity显示文摘 | Zong Hong Zhang Stephanie C.C. Tan Judice L.Y. Koh András Falus Vladimir Brusic | 2007 | Cellular Immunology2007，，2： | 1 |
| 8 | Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases显示文摘Macrophages are dominant innate immune cells.They demonstrate remarkable het-erogeneity and plasticity that are essential for homeostasis and host defense.The heterogeneity of tissue macrophages is shaped by the ontogeny,tissue factors,and environmental signals,a pattern in a tissue-associated latitudinal manner.At the same time,macrophages have long been considered as mainly plastic cells.These cells respond to stimulation quickly and in a stimulus-specific way by utilizing a longitudinal cascaded activation,including coordination of signal trans-ducer,epigenetic elements,and transcription factors,conclusively determine the macrophage phenotypes and functions.With the development of cutting-edge technologies,such as fate-mapping,single-cell transcriptomics,ipsc platform,nanotherapeutic materials,etc.,our under-standing of macrophage biology and the roles in the pathogenesis of diseases is much advanced.This review summarizes recent progress on the latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases.The latitudinal regulation covers the tissue macrophage or-igins,tissue factors,and environmental signals,reflecting the macrophage heterogeneity.The lon-gitudinal regulation focuses on how multiple factors shape the phenotypes and functions of macrophage subsets to gain plasticity in inflammatory diseases(i.e.,inflammatory bowel disease).In addition,how to target macrophages as a potential therapeutic approach and cutting edge-technologies for tissue macrophage study are also discussed in this review. | XiaoYi He Stephanie Tan Zhong Shao Xiao Wang | 2022 | Genes & Diseases2022，9，5： | 0 |
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