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| 1 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 2 | Empathic Neural Responses are Modulated by the PerceivedFairness of Others 显示文摘 | Singer T Seymour B 0 ’ Doherty J P Stephan K E Dolan R J FrithC D | 2006 | Nature2006，，439： | 1 |
| 3 | Empathic Neural Responses are Modulated by the PerceivedFairness of Others 显示文摘 | Singer T Seymour B 0 ’ Doherty J P Stephan K E Dolan R J FrithC D | 2006 | Nature2006，，439： | 1 |
| 4 | Dissipation and transport of veterinary sulfonamide antibiotics after manure application to grassland in a small catchment显示文摘 | Krispin Stoob Heinz P Singer Stephan R Mueller | 2007 | Environmental Science and Technology2007，41，21： | 1 |
| 5 | Empathic Neural Responses are Modulated by the Perceived Fairness of Others显示文摘 | Singer T Seymour B O'Doherty J P Stephan K E Dolan R L Frith C D | 2006 | Nature2006，439，26： | 1 |
| 6 | Differential diagnosis of benign and malign pancreatic masses with 18F-fluordeoxyglucose-positron emission tomography recorded with a dual-head coincidence gamma camera显示文摘 | Elisabeth Singer Michael Gschwantler Dina Plattner Stephan Kriwanek Christian Armbruster Johann Schueller Hans Feichtinger Rudolf Roka Peter Moeschl Werner Weiss Alois Kroiss | 2007 | European Journal of Gastroenterology & Hepatology2007，，6： | 1 |
| 7 | 2006, CONSTANS and the CCAAT box binding complex share a function- ally important domain and interact to regulate flowering of Arabidopsis显示文摘 | Stephan Wenkel Turck F Singer K | 2006 | Plant Cell2006，18，11： | 1 |
| 8 | Dissipation and transport of veterinary sulfonamide antibiotics after manure application to grassland in a small catchment显示文摘 | Krispin Stoob Heinz P Singer Stephan R Mueller | 2007 | Environmental Science Technology2007，41，21： | 1 |
| 9 | Triclosan :occurrence and fate of a widely used biocide in the aquatic environment: field measurements in wastewater treatment plants,surface waters, and lake sediments 显示文摘 | Heinz Singer Stephan Muller Celine Tixier | 2002 | Environ Sci Techno12002，36，： | 1 |
| 10 | Empathic neural responses are modulated by the perceived fairness of others显示文摘 | Singer T Seymour B O'Doherty J.P Stephan K.E Dolan R.J & Frith C.D | | 0，，7075： | 1 |
| 11 | Source area effects on herbicide losses to surface waters—A case study in the Swiss Plateau显示文摘 | Luciana Gomides Freitas Heinz Singer Stephan R. Müller René P. Schwarzenbach Christian Stamm | 2008 | Agriculture Ecosystems and Environment2008，，3： | 1 |
| 12 | Empathic Neural Responses are Modulated by the Per-ceived Fairness of Others显示文摘 | Singer T Seymour B O?Doherty J P Stephan K E Dolan R J Frith C D | | 0，，7075： | 1 |
| 13 | Empathic neural responses are modulated by the perceived fairness of others显示文摘 | Singer T Seymour B O'Doherty J P Stephan K E Dolan R L Frith C D | 2006 | Nature2006，439，： | 1 |
| 14 | Beware of gastric tube in esophagectomy after gastric radiotherapy:A case report显示文摘BACKGROUND Gastric tube formation and pull-up is the most common technique of reconstruction following esophagectomy for esophageal cancer.If previous treatment with radiotherapy for gastric mucosa-associated lymphoid tissue(MALT)-lymphoma restricts suitability of the stomach for anastomosis to the esophagus is unknown.CASE SUMMARY A 57-year-old man underwent sequential chemotherapy and radiotherapy for gastric MALT-lymphoma seven years prior to diagnosis of esophageal adenocarcinoma.Esophagectomy without neoadjuvant treatment was recommended by the multidisciplinary tumor board due to early tumor stage[uT1(sm2)uN+cM0 according to TNM-classification of malignant tumors,8^(th) edition]without lymph node involvement.Minimal invasive esophageal resection with esophagogastrostomy was performed.Due to gastric tube necrosis with anastomotic leakage on the twelfth postoperative day,diverting resection with construction of a cervical salivary fistula was necessary.Rapid recovery facilitated colonic interposition without any complications six months afterwards.CONCLUSION This case report may represent the start for further investigation to know if it is reasonable to refrain from esophagogastrostomy in patients with a long interval between gastric radiotherapy and surgery. | Can Yurttas Doerte Wichmann Cihan Gani Malte N Bongers Stephan Singer Christian Thiel Alfred Koenigsrainer Karolin Thiel | 2022 | World Journal of Clinical Cases2022，10，17： | 0 |
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