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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry显示文摘 | Michel Y Haller Stephan R Müller Christa S McArdell Alfredo C Alder Marc J.-F Suter | 2002 | Journal of Chromatography A2002，，1： | 2 |
| 3 | High donor FOXP3- positive regulatory T-cell ( Treg ) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT 显示文摘 | Katayoun R Stephan M Mojgan A | 2006 | Blood2006，108，： | 1 |
| 4 | Dexmedetomidine versus propo- foL/ midazolam for long-term sedation during mechanical ventilation 显示文摘 | Esko R lkka P Stephan M | 2009 | Intens Care Med2009，35，： | 1 |
| 5 | Concentrations and mass fluxes of chloroacetic acids and trifluoroacetic acid in rain and natural waters in Switzerland显示文摘 | MICHEAL B STEPHAN R M ADRIAN W | 2000 | Environ Sci Technol2000，34，： | 1 |
| 6 | Anti -CD20 - and B -cell re- ceptor - mediated apoptosis : evidence for shared intracellular signaling pathways 显示文摘 | Stephan M Anke R Kurt BB | 2000 | Cancer Research2000，60，24： | 1 |
| 7 | Novel placental and nonplacental serum markers in ectopic versus normal intrauterine pregnancy显示文摘 | Michael D M Luigi R Stephan S | 2004 | Fertil Steril2004，81，4： | 1 |
| 8 | Bacterial contamination of femoral head allografts from living donors显示文摘 | Stephan B W Vehmeyer Arnoud R M Slooff Rolf M Bloem Pieter L C Petit | 2002 | Acta Orthopaedica2002，，： | 1 |
| 9 | A bearingless method for induction machines显示文摘 | Salazar A O Stephan R M | 1993 | IEEE Transactions on Magnetics1993，29，6： | 1 |
| 10 | A general approach for DC apparent resistivity evaluation on arbitrarily shaped 3D structures显示文摘 | LAURENT M STEPHANE R SERGIO P L | 2006 | Journal of Applied Geophysics2006，，60： | 1 |
| 11 | An efficient controller for an adjustable speed induction-motor drive显示文摘 | GARCIA G O LUIS J C STEPHAN R M | 1994 | IEEE Transactions on Industrial Electronics1994，41，5： | 1 |
| 12 | Large-distance and long-time properties of a randomly stirred fluid 显示文摘 | NELSON D R STEPHAN M J | 1977 | Phys Rev1977，16，： | 1 |
| 13 | Nitrite toxicity arising from the use of urea as a fertilizer显示文摘 | COURT M N STEPHAN R C WAID J S | 1962 | Nature1962，194，： | 1 |
| 14 | Clinical imp lications of apoptosis in ischemic myocardium显示文摘 | SCARABELLI T M KNIGHT R STEPHANOU A | 2006 | Curt Probl Cardiol2006，31，3： | 1 |
| 15 | Acetobacter Diazotrophicus Sp.Nov.,a Nitrogen-Fixing acetic acid bacterium associated with sugarcane显示文摘 | GILLIS M K KERSTERS B HOSTE D JANSSENS R M KOPPENSTED M P STEPHAN K R S TEIXEIRA J DOBERENINER J DE LEY | | 0，，： | 1 |
| 16 | Donor-Substitu- ted 1, 3, 5-Triazines as Host Materials for Blue Phosphorescent Organic Light-Emitting Diodes 显示文摘 | Michael M R Stephan H Enrico D C | 2010 | Chem Mater2010，22，7： | 1 |
| 17 | Antibacterial activity of de-contamination treatments for pig carcasses 显示文摘 | Loretz M Stephan R Zweifel C | 2011 | Food Control2011，22，8： | 1 |
| 18 | A high normal TSH is associat- ed with the metabolic syndrome 显示文摘 | Stephan R Weickert MO Ayman M | 2010 | Clin Endocrinol2010，72，5： | 1 |
| 19 | Clinical implications ofapoptosis in ischemic myocardium 显示文摘 | Scarabellt T M Knight R Stephanou A | 2006 | Curr Probl Cardiol2006，31，： | 1 |
| 20 | Value of electronbeam computed tomography for the noninvasive detection of high-grade coronary-artery stenoses and occlusions 显示文摘 | Stephan A Werner M Dieter R | 1998 | N Engl J Med1998，339，27： | 1 |
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