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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases 显示文摘 | Tlaskalova-Hogenova H Stepankova R Hudcovic T | 2004 | Immunol Lett2004，93，： | 1 |
| 3 | Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering 显示文摘 | Prokop Z Sato Y Brezovsky J Mozga T Chaloupkova R Koudelakova T Jerabek P Stepankova V Natsume R van Leeuwen JGE Janssen DB Florian J Nagata Y Senda T Damborsky J | 2010 | Angew Chem Int Ed2010，49，： | 1 |
| 4 | Vitamin A deficiency leads to severe functional disturbance of the intestinal epithelium enzymes associated with diarrhoea and increased bacterial translocation in gnotobiotic rats显示文摘 | KOZAKOVA H HANSON L A STEPANKOVA R | 2003 | Microbes Infect2003，5，5： | 1 |
| 5 | Difference in development of lymphocyte subpopulations from Cut-Associated Lymphatic Tissue (GALT) of germfree and conventional rats:effect of aging显示文摘 | Stepankova R Sinkora J Hudcovic T | 1998 | Folia Microbiol1998，43，5： | 1 |
| 6 | Woody plants and stands in the health-resort park Brusno, evaluated for quality and quantity显示文摘 | Feriancova L Stepankova R | 2006 | Folia Oecologica2006，33，1： | 1 |
| 7 | Difference indevelopment of lymphocyte subpopulations from Gut-AssociatedLymphatic Tissue (GALT) of germfree and conventional rats:effect of aging显示文摘 | STEPANKOVA R SINKORA J HUDCOVIC T | 1998 | Folia Microbiol1998，43，5： | 1 |
| 8 | Commensal bacteria ( normal microflora) , mucosal immunity and chronic inflammatory and autoimmune diseases 显示文摘 | Tlaskalova-Hogenova H Stepankova R Hudcovic T | 2004 | Immunol Lett2004，93，23： | 1 |
| 9 | Commensal bacteria (normal micmflora), mucosal immunity and chronic inflammatory and autoimmtme diseases显示文摘 | Tlaskalova-Hogenova H Stepankova R Hudcovic T | 2004 | Immunol Lett2004，93，： | 1 |
| 10 | Commensal bacteria (normal microflora), mucosal immunity and chronicin flammatory and autoimmnne diseases显示文摘 | Tlaskalova-Hogenova H Stepankova R Hudcovic T | 2004 | Immunology Letters2004，93，23： | 1 |
| 11 | Absence of microbiota(germfree conditions)accelerates the atherosclerosis in Apo E-deficient mice fed standard low cholesterol diet显示文摘 | Stepankova R Tonar Z Bartova J | 2010 | J Atheroscler Thromb2010，17，8： | 1 |
| 12 | Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4 + T cells显示文摘 | STEPANKOVA R POWRIE F KOFRONOVA O | 2007 | Inflammat Bowel Dis2007，13，10： | 1 |
| 13 | Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases显示文摘 | Tlaskalova-Hogenova H Stepankova R Hudcovic T | 2004 | Immunol Lett2004，93，23： | 1 |
| 14 | Commensal bacteria (normal microflora),mucosal immunity and chronic inflammatory autoimmune diseases显示文摘 | Tlaskalova-Hogenova H Stepankova R Hudcovic T | 2004 | Immunol Lett2004，93，23： | 1 |
| 15 | Commen-sal bacteria (normal microflora) , mucosal immunity and chronic in-flammatory and autoimmune diseases 显示文摘 | TLASKALOVA-HOGENOVA H STEPANKOVA R HUDCOVIC T et al | 2004 | Imm unol Lett2004，93，23： | 1 |
| 16 | Absence of microbiota(germ-free conditions)accelerates the atherosclerosis in apoE-deficient mice fed standard low cholesterol diet显示文摘 | Stepankova R Tonar Z Bartova J Nedorost L Rossman P Poledne R | | 0，，08： | 1 |
| 17 | Effects of mi- croflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse显示文摘 | Williams AM Probert CS Stepankova R | 2006 | Immunology2006，119，4： | 1 |
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