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| 1 | Small intestinal bacterial overgrowth syndrome显示文摘Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO).SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of SIBO using glucose or lactulose. Therapy for SIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO. | Jan Bures Jiri Cyrany Darina Kohoutova Miroslav Frstl Stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，24： | 52 |
| 2 | An experimental study of two-phase flow in slightly inclline pipes-I flow patterns显示文摘 | Kokal S L Stanislav J F | 1989 | Chemical Engineering Science1989，44，3： | 1 |
| 3 | Interpretation of thermal well falloff testing 显示文摘 | STANISLAV J F EASWARAN C V KOKAL S L | 1989 | SPE Formation Evaluation1989，4，2： | 1 |
| 4 | Using virtual communities in tourism research显示文摘 | Steven F Illum Stanislav H Ivanov Yating Liang | 2010 | Tourism Management2010，31，3： | 1 |
| 5 | Architecture and enablers for optimized radio resource usage in heterogeneous wireless access networks显示文摘 | Soodesh B Hiroshi H Stanislav F | 2009 | IEEE Communications Magazine2009，47，1： | 1 |
| 6 | Investigation of crack propagation scatter in a gear tooth's root显示文摘 | Stanislav P Janez K Jo(z)e F | 2008 | Engineering Fracture Mechanics2008，75，5： | 1 |
| 7 | An experimental study of two-phase flow in slightly inclined pipes Ⅰ 显示文摘 | KOKAL S L STANISLAV J F | 1989 | Chemical Engineering Science1989，44，3： | 1 |
| 8 | Synthesis and stabilization of nano-sized titanium dioxide显示文摘 | Zinfer R Ismagilov L T Tsikoza N V Shikina V F Zarytova V V Zinoviev Stanislav N Zagrebelnyi | 2009 | Russian Chemical Reviews2009，，9： | 1 |
| 9 | Using virtual communities in tourism research显示文摘 | Steven F Ilium Stanislav H Ivanov Yating Liang | 2010 | Tourism Management2010，31，： | 1 |
| 10 | An analysis of two-phase flow in inclined pipes with zero net liquid production显示文摘 | Stanislav J F | 1986 | J Can Pet Tech1986，25，6： | 1 |
| 11 | Structures in the cell-wall that enable hygroscopic morement of wheat awns 显示文摘 | Rivka E Stanislav G Peter F | 2008 | Journal of Structural Biology2008，16，4： | 1 |
| 12 | An experimental study of two- phase flow in slightly inclined pipes-I 显示文摘 | Kokal S L Stanislav J F | 1989 | Chemical Engineering Science1989，44，3： | 1 |
| 13 | Numerical methods for determining stress intensity factors vs crack depth in gear tooth roots 显示文摘 | STANISLAV P TREVOR K H JASE F | 1997 | International Journal of Fatigue1997，19，10： | 1 |
| 14 | An experimental study of two phase flow in slightly in clined pipes- liquid holdup and pressure drop 显示文摘 | KOKAL S L STANISLAV J F | 1989 | Chemical Engineering Science1989，44，3： | 1 |
| 15 | German population data of three tetrameric short tandem repeat lociD3S1744, D12S1090 and D18S849 显示文摘 | Christina S Thomas L Stanislav F | 1998 | Forensic Science International1998，91，： | 1 |
| 16 | Structure and mechanics of the tarsal chain in the hornet, vespa crabro (hymenoptera: vespidae) : implications on the attachment mechanism 显示文摘 | LEONID F STANISLAV G | 2004 | Arthropod Structure & Development2004，33，1： | 1 |
| 17 | Bacteriocinogeny in experimental pigs treated with indomethacin and Escherichia coli Nissle显示文摘AIM:To evaluate bacteriocinogeny in short-term highdose indomethacin administration with or without probiotic Escherichia coli Nissle 1917(EcN) in experimental pigs.METHODS:Twenty-four pigs entered the study:Group A(controls),Group B(probiotics alone),Group C(indomethacin alone) and Group D(probiotics and indomethacin).EcN(3.5 × 1010 bacteria/d for 14 d) and/or indomethacin(15 mg/kg per day for 10 d) were administrated orally.Anal smears before and smears from the small and large intestine were taken from all animals.Bacteriocin production was determined with 6 different indicator strains;all strains were polymerase chain reaction tested for the presence of 29 individual bacteriocinencoding determinants.RESULTS:The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria(parallel genotypes A,B1,B2 and D found).In total,637 bacterial strains were tested,mostly Escherichia coli(E.coli).There was a higher incidence of non-E.coli strains among samples taken from the jejunum and ileum compared to that of the colon and rectum indicating predominance of E.coli strains in the large intestine.Bacteriocinogeny was found in 24/77(31%) before and in 155/560(28%) isolated bacteria at the end of the study.Altogether,13 individual bacteriocin types(out of 29 tested) were identified among investigated strains.Incidence of four E.coli genotypes was equally distributed in all groups of E.coli strains,with majority of genotype A(ranging from 81% to 88%).The following types of bacteriocins were most commonly revealed:colicins Ia/Ib(44%),microcin V(18%),colicin E1(16%) and microcin H47(6%).There was a difference in bacteriocinogeny between control group A(52/149,35%) and groups with treatment at the end of the study:B:31/122(25%,P = 0.120);C:43/155(28%,P = 0.222);D:29/134(22%,P = 0.020).There was a significantly lower prevalence of colicin Ib,microcins H47 and V(probiotics group,P < 0.001),colicin E1 and microcin H47(indomethacin group,P < 0.001) and microcins H47 and V(probiotics and indomethacin group,P = 0.025) compared to controls.Escherichia fergusonii(E.fergusonii) was identified in 6 animals(6/11 isolates from the rectum).One strain was non-colicinogenic,while all other strains of E.fergusonii solely produced colicin E1.All animals started and remained methanogenic despite the fact that EcN is a substantial hydrogen producer.There was an increase in breath methane(after the treatment) in 5/6 pigs from the indomethacin group(C).CONCLUSION:EcN did not exert long-term liveability in the porcine intestine.All experimental pigs remained methanogenic.Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny. | Jan Bures David Smajs Jaroslav Kvetina Miroslav Frstl Jan Smarda Darina Kohoutova Martin Kunes Jiri Cyrany Ilja Tacheci Stanislav Rejchrt Jirina Lesna Viktor Vorisek Marcela Kopacova | 2011 | World Journal of Gastroenterology2011，17，5： | 0 |
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