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| 1 | Serum cytokine profile in patients with hepatitis B e antigen-negative chronic active hepatitis B and inactive hepatitis B virus carriers显示文摘An insufficient cellular immune response seems to be critical for the immunopathogenesis of chronic hepatitis B virus infection.We have previously demonstrated no differences of T-lymphocyte subsets in blood between inactive hepatitis B s antigen(HBsAg) carriers and patients with HBeAg-negative chronic active hepatitis B.This study investigated the peripheral blood cytokine profile in patients with HBeAg-negative chronic active hepatitis B infection(Group A,n = 21) and inactive HBsAg carriers(Group B,n = 13).Serum cytokines [interferon(IFN)-γ,tumor necrosis factor-α,interleukin(IL)-1b,IL-4,IL-12,IL-10,IL-2,IL-5,IL-8] were analyzed by using flow cytometry.Patients with chronic active disease presented with significantly decreased levels of IFN-γ and IL-10 compared to inac-tive carriers(P = 0.048 and P = 0.008,respectively).In HBeAg-negative chronic active hepatitis B patients,a significant negative correlation of IFN-γ levels with serum hepatitis B viral load was noted(P = 0.021).In conclusion,patients with HBeAg-negative chronic active hepatitis B and HBsAg inactive carriers display a different cytokine profile.Decreased Th1 response observed in patients with chronic active hepatitis B could be implicated in the persistence of virus replication and ongoing progression of liver disease. | Dimitra Dimitropoulou Marina Karakantza Georgios L Theodorou Lydia Leonidou Stelios F Assimakopoulos Athanasia Mouzaki Charalambos A Gogos | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 13 |
| 2 | Optimal and robust control for linear state-delay systems显示文摘 | MICHAEL B JESUS R G LEONID F | 2007 | Journal of the Franklin Institute2007，344，6： | 1 |
| 3 | Optical Closure for the Remote Sensing Reflectance based on Accurate Radiative Transfer Approxi mations:The Case of Changjiang( Yangtze)River Estuary and Its Adjacent Coastal Area, China显示文摘 | Leonid G S Shen F | 2014 | International Journal of Remote Sensing2014，5，12： | 1 |
| 4 | Analysis design of integral sliding manifolds for sYstems with unmatched perturbations 显示文摘 | Fernando C Leonid F | 2006 | IEEE Transactions on Automatic Control2006，51，5： | 1 |
| 5 | Analysis and design of integral sliding manifolda for systems with unmatched perturbations显示文摘 | Fernando C Leonid F | 2006 | IEEE Trans on Automatic Control2006，51，5： | 1 |
| 6 | Nonlinear total variation based noise removal algorithms显示文摘 | LEONID I R STANLEY O EMAD F | 1992 | Physica D: Nonlinear Phenomena1992，60，1： | 1 |
| 7 | Efficiencies of master,replica,and multilayer gratings for the soft-X-ray-extreme-ultraviolet range:modeling based on the modified integral method and comparisons with measurements显示文摘 | Leonid I Goray John F Seely | 2002 | Applied Optics2002，41，7： | 1 |
| 8 | Nonlinear total variation based noise removal algor'thms显示文摘 | LEONID 1 R STANLEY O EMAD F | 1992 | Physica D Noolin for Ploc- nomena1992，60，4： | 1 |
| 9 | Solid state synthesis of NiAl-Nb composites from fine lemental powders 显示文摘 | Leonid F Irena G | 1998 | Materials Science and Engineering1998，244，： | 1 |
| 10 | Statistical significance of protein structure prediction by threading显示文摘 | LEONID A M ALEXEY V F EUGENE I S | 2000 | PNAS2000，97，： | 1 |
| 11 | Analysis and design of integral sliding manifolds for systems with unmatched perturba- tions显示文摘 | Fernando C Leonid F | 2006 | IEEE Transactions on Automatic Control2006，51，5： | 1 |
| 12 | Analysis and design integral sliding manifolds for systems with uncertained perturbations显示文摘 | Fernando C Leonid F | 2006 | IEEE Transactions on Au- tomatic Control2006，51，5： | 1 |
| 13 | Structure and mechanics of the tarsal chain in the hornet, vespa crabro (hymenoptera: vespidae) : implications on the attachment mechanism 显示文摘 | LEONID F STANISLAV G | 2004 | Arthropod Structure & Development2004，33，1： | 1 |
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