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| 1 | Secretion of immunoregulatory cytokines by mesenchymal stem cells显示文摘According to the minimal criteria of the International Society of Cellular Therapy, mesenchymal stem cells(MSCs) are a population of undifferentiated cells defined by their ability to adhere to plastic surfaces when cultured under standard conditions, express a certain panel of phenotypic markers and can differentiate into osteogenic, chondrogenic and adipogenic lineages when cultured in specific inducing media. In parallel with their major role as undifferentiated cell reserves, MSCs have immunomodulatory functions which are exerted by direct cell-to-cell contacts, secretion of cytokines and/or by a combination of both mechanisms. There are no convincing data about a principal difference in the profile of cytokines secreted by MSCs isolated from different tissue sources, although some papers report some quantitative but not qualitative differences in cytokine secretion. The present review focuses on the basic cytokines secreted by MSCs as described in the literature by which the MSCs exert immunodulatory effects. It should be pointed out that MSCs themselves are objects of cytokine regulation. Hypothetical mechanisms by which the MSCs exert their immunoregulatory effects are also discussed in this review. These mechanisms may either influence the target immune cells directly or indirectly by affecting the activities of predominantly dendritic cells. Chemokines are also discussed as participants in this process by recruiting cells of the immune systems and thus making them targets of immunosuppression. This review aims to present and discuss the published data and the personal experience of the authors regarding cytokines secreted by MSCs and their effects on the cells of the immune system. | Dobroslav Kyurkchiev Ivan Bochev Ekaterina Ivanova-Todorova Milena Mourdjeva Tsvetelina Oreshkova Kalina Belemezova Stanimir Kyurkchiev | 2014 | World Journal of Stem Cells2014，6，5： | 20 |
| 2 | Torrential flood prevention in the Kolubara river basin显示文摘One of the most vulnerable parts to natural hazards in Serbia is Kolubara river basin. In the past, during the period from 1929 to 2013, 121 torrential flood events in the Kolubara river basin were recorded which show that this territory is extremely vulnerable to the torrential floods. The extreme event which occurred in May 2014 causing the catastrophic material damages and casualties was the latest and historical flood. The analysis of natural conditions in the Kolubara basin uniformly showed that this area is predisposed to a greater number of torrential floods due to its geomorphological, hydrological and land use properties. Torrential floods are closely related to the intensity and spatial distribution of erosive processes in the upper part of the Kolubara basin. The estimation of soil erosion potential is generally achieved by Erosion Potential Model(EPM). For the purposes of determining the degree of torrential properties in various water streams in the Kolubara basin, the calculation ofsusceptibility to torrential floods was assessed by Flash Flood Potential Index(FFPI). More than half of the basin area(57.2%) is located within the category of very weak and weak erosion(Z_(sr) = 0.35), but the category of medium erosion is geospatially very common. Such a distribution of medium erosion category provides conditions for generating, i.e. production of sediment which would boost torrential properties of water streams. After the classification of the obtained FFPI values it was determined that 25% of the Kolubara basin is very susceptible to torrents and this data should be seriously taken into consideration. Based on the analyses, the best and most successful manner of defence is prevention which consists of the integrated river basin management system(integrated torrent control system) so that technical works in hydrographic networks of torrents and biological and biotechnical works on the slope of the basin would be the best solution. Permanent control of erosive and torrential processes in the river basin will be not only important for flood control but it can also protect the existing and future water reservoirs and retentions fromsiltation with erosion sediment which is of great significance to the water management, agriculture, energy sector, and the entire society. | KOSTADINOV Stanimir DRAGI?EVI? Slavoljub STEFANOVI? Tomislav NOVKOVI? Ivan PETROVI? M.Ana | 2017 | Journal of Mountain Science2017，14，11： | 2 |
| 3 | The effectiveness of Regulation FD显示文摘 | Andreas Gintschel Stanimir Markov | 2004 | Journal of Accounting and Economics2004，，3： | 1 |
| 4 | Loss function assumptions in rational expectations tests on financial analysts' earnings forecasts显示文摘 | Sudipta Basu Stanimir Markov | 2004 | Journal of Accounting and Economics2004，38，： | 1 |
| 5 | Inducing Compliance' in WTO Dispute Settlement显示文摘 | David Palmeter Stanimir Alexandrov | 2007 | The Political economy of International Trade law2007，，4： | 1 |
| 6 | Effect of Progesterone on Human Mesenchymal Stem Cells显示文摘 | Dobroslav S. Kyurkchiev Ekaterina Ivanova-Todorova Stanimir D. Kyurkchiev | 2011 | Vitamins and Hormones2011，，： | 1 |
| 7 | High effciency adenovirus-mediated gene transfer to human dendritic cells显示文摘 | Allan B D Stanimir V P | 1998 | Blood1998，91，2： | 1 |
| 8 | FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis显示文摘 | Soren Hayrabedyan Stanimir Kyurkchiev Ivan Kehayov | 2005 | Journal of Reproductive Immunology2005，67，12： | 1 |
| 9 | Dynamic meniscus profile method for determination of the dynamic contactangle in the Wilhelmy geometry显示文摘 | Stanimir D Iliev Nina C Pesheva | 2011 | Colloids Surf A:Physicochem Eng Aspects2011，385，13： | 1 |
| 10 | Loss function assumptions in rational expectations tests on financial analysts’ earnings forecasts显示文摘 | Sudipta Basu Stanimir Markov | 2004 | Journal of Accounting and Economics2004，，： | 1 |
| 11 | Using antifibrinolytics to tackle neuroinflammation显示文摘Plasmin is generally known as a promotor of inflammation.Recent advancement suggests that it has a complex role as immunity modulator.Pharmacological inhibition of plasmin production and activity has been proven to improve neurological outcomes in traumatic brain injury and subarachnoid hemorrhage,most probably by preventing re-bleeding.The immune-modulatory properties of antifibrinolytics,however,suggest that they probably have effects unrelated to fibrinolysis inhibition,which are currently not adequately harnessed.The present work aims to give an account of the existing data regarding antifibrinolytics as agents influencing neuroinflammation.Preclinical and clinical studies on the possible influence of antifibrinolytics on neuroinflammation are scarce.However,the emerging evidence suggests that inhibition of plasmin(ogen)activity can ameliorate neuroinflammation to some extent.This data demonstrate that plasmin(ogen)is not exclusively involved in fibrinolysis,but also has other substrates and can precipitate in inflammatory processes.Investigation on the role of plasmin as the factor for the development of neuroinflammation shows the significant potential of antifibrinolytics as pharmacotherapy of neuroinflammationm,which is worthy of further exploration. | Stanimir Atsev Nikola Tomov | 2020 | Neural Regeneration Research2020，15，12： | 1 |
| 12 | Prognostic factors and outcome in women with uterine sarcoma显示文摘 | Denschlag D Masoud I Stanimir G | 2007 | Eur J Surg Oncol2007，33，1： | 1 |
| 13 | The Effectiveness of Regulation FD, 显示文摘 | Andreas Gintschel Stanimir Markov | 2004 | Journal of Accounting and Economics2004，，37： | 1 |
| 14 | Endoglin (CD105) and S100A13 as markers of active angiogenesis in endometriosis显示文摘 | Soren H Stanimir K Ivan K | 2005 | Reproductive Biology2005，5，1： | 1 |
| 15 | Prognostic factors and outcome in women with uterine sarcoma 显示文摘 | Denschlag D Masoud I Stanimir G | 2007 | Eur J Surg Oncol2007，33，1： | 1 |
| 16 | FGF-1 and S100A13 Possibly Contribute to Angiogenesis in an Dometriosis显示文摘 | Soren H Stanimir K Ivan K | 2005 | J Reprod Immunol2005，67，12： | 1 |
| 17 | Resonant contactless energy transfer with improved efficiency显示文摘 | STANIMIR V SENIOR M | 2009 | IEEE Transactions on Power Elec- tronics2009，24，3： | 1 |
| 18 | Endoglin (cdl05) and S100A13 as mark ers of active angiogenesis in endometriosis显示文摘 | Soren H Stanimir K Ivan K | 2005 | Reprod Biol2005，5，1： | 1 |
| 19 | Conditioned Medium from Adipose Tissue-Derived Mesenchymal Stem Cells Induces CD4+FOXP3+ Cells and Increases IL-10 Secretion显示文摘 | Ekaterina Ivanova-Todorova Ivan Bochev Rumen Dimitrov Kalina Belemezova Milena Mourdjeva Stanimir Kyurkchiev Plamen Kinov Iskra Altankova Dobroslav Kyurkchiev Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 1 |
| 20 | Leiomyomatosis peritonealis disseminata with features of carcinomatosis on laparoscopy , a case report显示文摘 | Al-Talib A AI-Farsi AR Stanimir G | 2009 | Sultan Qahoos Univ MedJ2009，9，3： | 1 |
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