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| 1 | Marking RNA:m^6A writers,readers,and functions in Arabidopsis显示文摘N^6-methyladenosine(m^6A)emerges as an important modification in eukaryotic mRNAs.m^6A has first been reported in 1974,and its functional significance in mammalian gene regulation and importance for proper development have been well established.An arsenal of writer,eraser,and reader proteins accomplish deposition,removal,and interpretation of the m^6A mark,resulting in dynamic function.This led to the concept of an epitranscriptome,the compendium of RNA species with chemical modification ofthe nucleobases in the cell,in analogy to the epigenome.While m^6A has long been known to also exist in plant mRNAs,proteins involved in m^6A metabolism have only recently been detected by mutant analysis,homology search,and mRNA interactome capture in the reference plant Arabidopsis thaliana.Dysregulation ofthe m^6A modification causes severe developmental abnormalities of leaves and roots and altered timing of reproductive development.Furthermore,m^6A modification affects viral infection.Here,we discuss recent progress in identifying m^6A sites transcriptome-wide,in identifying the molecular players involved in writing,removing,and reading the mark,and in assigning functions to this RNA modification in 4.thaliana.We highlight similarities and differences to m^6A modification in mammals and provide an outlook on important questions that remain to be addressed. | Marlene Reichel Tino Koster Dorothee Staiger | 2019 | Journal of Molecular Cell Biology2019，11，10： | 13 |
| 2 | A Processive Arabidopsis Formin Modulates Actin Filament Dynamics in Association with Profilin显示文摘Formins 是被含有为房间分割和房间极性重要的肌动朊细胞骨架组织和动力学的保存管理者。由哪个多样的 formins 在植物调整肌动朊动力学的机制仍然不好被理解。在 vitro 使用单个分子的成像技术,我们直接观察到 Arabidopsis thaliana formin 的 FH1-FH2 领域, AtFH14, processively 属于是的肌动朊细丝的有倒钩的目的一更暗淡并且在 90% 减缓他们的延伸率。FH1-FH2 的附件坚持是集中依赖者。由三倍颜色的全部的内部思考荧光显微镜学的使用,而且,我们发现了那 ABP29,有倒钩结束的盖住蛋白质,在细丝与 FH1-FH2 竞争有倒钩的结束,在它的绑定与 AtFH14 是互相独占的的地方。面对不同植物 profilin isoforms, FH1-FH2 从大约 10 ~ 42 次提高细丝延伸率。细丝扣环当 FH1-FH2 明确地被抛锚盖住幻灯片时,推进显示 AtFH14 在伸长上 processively 移动有倒钩的结束。在高集中, AtFH14 随机绑肌动朊细丝进反平行或平行的像锭子的结构;然而, FH1-FH2-mediated 捆变得面对植物 profilins 更薄、更长。这是从植物的 processive formin 的直接示范。我们的结果也在与 profilin 经由协会调整肌动朊动力学照亮 AtFH14 的分子的机制。 | Sha Zhang Chang Liu Jiaojiao Wang Zhanhong Ren Christopher J. Staiger Haiyun Ren | 2016 | Molecular Plant2016，9，6： | 5 |
| 3 | Magnesium and its alloys as orthopedic biomaterials: A review显示文摘 | Mark P. Staiger Alexis M. Pietak Jerawala Huadmai George Dias | 2005 | Biomaterials2005，，9： | 4 |
| 4 | Magnesium and its alloys as orthopedic biomaterials: A review显示文摘 | Mark P. Staiger Alexis M. Pietak Jerawala Huadmai George Dias | 2005 | Biomaterials2005，，9： | 4 |
| 5 | Assessing the corrosion of biodegradable magnesium implants: A critical review of current methodologies and their limitations显示文摘 | N.T. Kirkland N. Birbilis M.P. Staiger | 2011 | Acta Biomaterialia2011，，3： | 2 |
| 6 | 布赫液压比例阀和平衡阀的应用显示文摘起重机、挖掘机和高空工作平台等行走机械,液压元件将用户的指令转化为动作,液压泵、液压缸、液压马达、比例阀和平衡阀都在各自的位置上发挥着重要作用。 | Hans Staiger 彭京球 | 2010 | 工程机械与维修2010，，6： | 2 |
| 7 | Relationship of serum adiponectin and leptin concentrations with body fat distribution in human显示文摘 | Staiger H Tschritter O Machann J | 2003 | Obes Res2003，11，3： | 1 |
| 8 | Assessing the corrosion of biodegradable magnesium implants: A critical review of current methodologies and their limitations 显示文摘 | KIRKLAND N T BIRBILIS N STAIGER M P | 2012 | Acta Biomaterialia2012，8，3： | 1 |
| 9 | Migration of paradoxie embolus through a patent foramen ovale diagnosed by echocardiography: suc- cessful thrombolysis显示文摘 | Hust MH Staiger M Braun B | 1995 | Am Heart J1995，129，3： | 1 |
| 10 | Breast cancer measurements with magnetic resonance imaging, ultrasonography, and mammography 显示文摘 | Davis PL Staiger M J Harris KB | 1996 | Breast Cancer Res Treatment1996，37，1： | 1 |
| 11 | Alpha 2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans显示文摘 | Stefan N Hennige AM Staiger H | | 0，，04： | 1 |
| 12 | Association between hospital recognition for nursing excellence and outcomes of very low - birth - weight infants显示文摘 | Lake ET Staiger D Horbar J | 2012 | JAMA2012，307，16： | 1 |
| 13 | Magnesium and its alloys as orthopedic biomaterials: a review 显示文摘 | Staiger MP Pietak AM Huadmai J | 2006 | Biomatefials2006，27，9： | 1 |
| 14 | How hospital ownership affects access to care for the uninsured显示文摘 | Norton E C Staiger D O | 1994 | Rand Journal of Economics1994，25，1： | 1 |
| 15 | The actin cytoskeleton is a target of the self-incompatibility response in Papaver rhoeas显示文摘 | Staiger C J | 2003 | J Exp Bot2003，80，： | 1 |
| 16 | Multilateral Tariff Cooperation During The Formation of Free Trade Areas显示文摘 | Bagwell K Staiger R | 1997 | International Economic Review1997，38，2： | 1 |
| 17 | Variation in the FTO gene influences food intake but not energy ex- penditure 显示文摘 | HAUPT A THAMER C STAIGER H | 2009 | Experimental and Clinical Endocrinology & Diabetes2009，117，4： | 1 |
| 18 | A green fluorescent protein fusion to actin-binding domain 2 of Arabidopsis fimbrin highlights new features of a dynamic actin cytoskeleton in live plant cells显示文摘 | Sheahan M B Staiger C J Rose R J | 2004 | Plant Physiology2004，136，： | 1 |
| 19 | Magnesium and its alloys as orthopedic biomaterials: A review显示文摘 | Staiger M P Pietak A M Huadmai J | 2006 | Biomaterials2006，27，： | 1 |
| 20 | The NAIRU,Un-employment and Monetary Policy显示文摘 | Staiger D J.Stock M.Watson | | 0，，02： | 1 |
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