|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Some characteristics and evolution of the internal soliton in the northern South China Sea显示文摘Based on the observational data of an internal soliton in the northern South China Sea (SCS) on June 14, 1998, the possible source of the internal soliton is analyzed, and some of its characteristic parameters such as phase speed, wave length, etc. are computed. Based on the analyses of the vertical modes of the internal wave, the characteristics of the wave-induced current during the propagation of the internal soliton are studied. A regularized long wave (RLW) equation numerical model considering effects of multi-fac-tors is employed, and the observed environmental parame-ters are used as the initial conditions to simulate the propa-gation and evolution of the internal soliton in the continental shelf of the northern SCS. | Cai, SQ Gan, ZJ Long, XM | 2002 | Chinese Science Bulletin2002，47，1： | 23 |
| 2 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 3 | Influence of splanchnic vascular infusion on the content of endotoxins in plasma and the translocation of intestinal bacteria in rats with acute hemorrhage necrosis pancreatitis显示文摘INTRODUCTIONThe main reason for the death of the patient with acutehemorrhage necrosis pancreatitis(AHNP)is pancreaticinfection and multi-organ failure caused by endotoxemiaand intestinal bacterial translocation.However,thepathogenesis of endotoxemia and intestinal | Qin RY Zou SQ Wu ZD Qiu FZ | 2000 | World Journal of Gastroenterology2000，6，4： | 15 |
| 4 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 5 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 6 | Bioactive asterosaponins from the starfish Culcita novaeguineae显示文摘 | Tang HF Yi YH Li L Sun P Zhang SQ Zhao YP | 2005 | 第二军医大学学报2005，26，8： | 5 |
| 7 | 基于原发肿瘤表观扩散系数直方图分析预测高级别浆液性卵巢癌患者铂类药物化疗敏感性显示文摘高级别浆液性卵巢癌(HGSOC)是最常见和最致命的卵巢癌组织学亚型,初始肿瘤细胞减灭术后进行一线铂类药物化疗是其标准的治疗方法,但其治疗后复发率高达75%。运用间隔6个月有无复发这一非常简单有效的方法对铂敏感及铂耐药患者进行分类,并能为后续的个体化治疗方案选择提供客观依据。弥散加权成像(DWI)可以利用表观扩散系数(ADC)检测细胞和细胞膜的完整性,以量化水分子在组织中的扩散程度,而基于ADC分析的直方图则可分析肿瘤的生物异质性。该研究通过治疗前阶段HGSOC原发病变全肿瘤区域和全实性肿瘤区域ADC直方图分析,对患者铂类药物的化疗反应予以预测。 | Lu J Li HM Cai SQ 毛咪咪(编译) | 2022 | 中华医学杂志2022，102，3： | 5 |
| 8 | 从美国刑事法律沿革思考我国司法精神病鉴定模式的转变显示文摘2008年4月3—6日笔者有幸参加了美国司法精神病学院在旧金山举行的第26届学术论坛。来自司法精神病学、犯罪心理学、法学界等领域的100余名代表参加了会议,32名专家、学者在会上做了丰富多彩的专题演讲。会议内容涉及司法精神病学的各个方面,其中有关司法精神病学专家证词的限制及局限性的重要讲座^[1],强调凡是刑事案件的司法精神病学鉴定的专家证言、证词,应当严格按照《联邦精神病辩护改革法》^[2](以下简称改革法)的有关规定撰写鉴定意见。在此,我们结合该改革法的内容及历史背景,对我国刑事案件司法精神病鉴定模式的转变谈一点体会。 | 高北陵 Li SQ | 2009 | 中华精神科杂志2009，42，1： | 5 |
| 9 | 恩替卡韦诱导的干扰素λ1对乙型肝炎肝硬化患者Ⅱ型固有淋巴细胞的抑制作用显示文摘[据Journal of Viral Hepatitis 2021年5月报道]题:恩替卡韦诱导的干扰素λ1对乙型肝炎肝硬化患者Ⅱ型固有淋巴细胞的抑制作用(作者Wang SQ等)已有研究证实,恩替卡韦在抗HBV过程中发挥着免疫调节作用。本研究旨在确定在HBV相关肝病进程中,恩替卡韦对非自然杀伤固有淋巴细胞(non-NK ILCs)的影响。 | 王思奇 蒋炜 WANG SQ SHEN Y LI J | 2021 | 临床肝胆病杂志2021，37，7： | 4 |
| 10 | 评定染色物匀染性的客观方法显示文摘一、导论染色不均匀在染整生产中一般是不能接受的,除非是石磨、酸洗或颜料染色的纺织品,因为它是依照流行趋势来寻求效果的。评定均匀发性(或不均匀性)的传统方法是通过目测或与类似的例如对同一批织物的样品比较,测定颜色的差异。这些方法多少带有主观性。我们试图应用分光光度技术,确定一个相对不均匀指数(RUI),以此来评定染色样品的不均匀程度。这一指数使我们有可能定量地表示均匀与不均匀度。二、相对不均匀指数(RUI) | CL Chong SQ Liang KW Yeung 洪瑞熔 | 1994 | 丝绸技术1994，2，2： | 4 |
| 11 | Synthesis and Characterization of Nanocrystalline Ni-Ti and Ni-Cr Powders by Mechanical Alloying显示文摘Nanocrystalline powders in the Ni-Ti and Ni-Cr systems were prepared by mechanical alloying (MA) of elemental crystalline powders in an inert atmosphere. The microstructure of the mechanically alloyed powders were characterized by XRD and TEM. The ball-milling process results in a drastic decrease of the crystallite size to the nanometer scale. X-ray diffraction analysis reveals that in the Ni-Cr system, no diffraction peaks from NiCr compound were observed even after 20 h of ball milling; while the lattice parameter of Ni increased with the milling time. In the Ni-Ti system, amorphous alloy was formed. Crystalline intermetallic compounds were obtained by post heat treatment of the amorphous alloy.The crystallization temperature of the amorphous NiTi alloy was obtained be DSC measurement. | Chen, SQ Zhou, YC Li, YY He, SH | 1997 | Journal of Materials Science & Technology1997，13，2： | 2 |
| 12 | Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN显示文摘AIM To investigate the pathogenic effect ofSEB and D-GalN on liver and the protection ofcyclosporin A, the relationship between hepaticapoptosis and necrosis and the possiblemechanism of acute hepatic necrosis.METHODS After staphylococcal enterotoxin B(SEB ) mixed with D--galactosamine (D-GaiN )were injected intraperitoneally into Balb/c miceand those previously treated with cyclosporin A,blood samples were collected and livers wereisolated at 2, 6, 12 and 24 h. Patterns othepatocellular death were studiedmorphologically and biochemically, circulatingcytokines (TNF-a, IFN--y ) and mice mortalitywithin 24h was assessed.RESU’LTS The SEB could induce the typicalapoptotic changes of hepatocytes, the D-GaiNcould induce hepatocytes apoptosis anddegeneration at the same time, and the micehaving received the SEB + D-GaiN injectionsdeveloped apoptosis at 2 and 6 h, but after 12 hhepatocytes were characterized by severein jury, whereas all the examinations in thecyclosporin A treated mice were normal.CONCLUSION Hepatic cell apoptosis might berelated to necrosis, and massive hepatocyteapoptosis is likely the initiating step of acutehepatic necrosis in mice. The effects induced bySEB and D--GaiN on hepatocytes might bemediated by T cells, and could be prevented bycyclosporin A. | Yin, T Tong, SQ Xie, YC Lu, DY | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 13 | Changes in the rheological properties of blood vessel tissue remodeling in the course of development of diabetes显示文摘 | LIU SQ FUNG YC | 1992 | Biorheology1992，29，56： | 2 |
| 14 | Functional anatomy of a dsRNA trigger : differential requirement for the two trigger strands in RNA interference显示文摘 | Parrish S Fleenor J Xu SQ | 2000 | Mol Cell2000，6，5： | 1 |
| 15 | Dialysis Access Related Infcetions显示文摘 | Lew SQ Kaveh K | 2000 | ASAIO J2000，46，6： | 1 |
| 16 | Bioluminescent method for detecting telomerase activity显示文摘 | Xu SQ He M Yu HP | 2002 | Clin Chem2002，48，： | 1 |
| 17 | Characterization of GMP-17 , a granule membrane protein that moves to the plasma membrane of natural Killer cells following target cell recognition 显示文摘 | Medley QG Kedersha NS Brien SQ etal | 1996 | Proc Natl Acad SciUSA1996，93，： | 1 |
| 18 | Treatment of spinal cord injury with co-grafts of genetically modified Schwann cells and fetal spinal cord cell suspension in the rat显示文摘 | Feng SQ Kong XH Guo SF | 2005 | Neurotox Res2005，7，12： | 1 |
| 19 | Hypertension prevalence and status ofawareness,treatment and control in China显示文摘 | Tao SQ Wu XG Duan XF | 1995 | China Med J1995，，108： | 1 |
| 20 | Metformin reverses fatty liver disease in obese,leptin-deficient mice显示文摘 | Lin HZ Yang SQ Chuckaree C | 2000 | Nat Med2000，6，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员