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136篇 您的检索式:作者名="Spraul"
    题名 作者 年代 出处 被引量
1基于HPLC-DAD-SPE-CryoNMR-MS技术的代谢物快速定性和结构确定(英文)显示文摘快速定性并有效地确定代谢物结构是代谢组学、植物化学和天然药物发现等研究的重要内容.本文以迷迭香的两种溶剂提取物(氯仿/甲醇=3/1和50%含水甲醇)作为模型样品,通过分析其中的一些化学成分,展现了HPLC-DAD-SPE-CryoNMR-MS无缝联仪技术在确定代谢物结构方面的应用潜力.基于高效液相色谱、紫外吸收、核磁共振波谱及质谱数据,具有代表性的6个迷迭香代谢物的结构得到了确定,它们分别为1个酚类二萜(鼠尾草酚)、2个酚酸(迷迭香酸和咖啡酸)、2个黄酮(6-甲氧基木樨草素-7-葡萄糖苷和高车前甙)和1个香豆酸(顺-4-香豆酸葡萄糖苷).该技术使分析型HPLC柱所分离的组分可以获得高质量同核及异核二维核磁共振波谱,从而能够更加便捷地确定微量成分的结构.这些研究结果不仅提供了上述6种代谢物详细的谱学数据,而且证实HPLC-DAD-SPE-CryoNMR-MS技术是天然产物以及其他复杂体系结构分析的重要工具,即使同一色谱峰中含有浓度相差一个数量级的多个代谢物时,该方法依然有效.肖超妮 刘红兵 戴惠 曾麗鸿 Manfred Spraul 王玉兰 唐惠儒 2009波谱学杂志2009,26,1:5
2750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma显示文摘Nicholson JK Foxall PJ Spraul M Farrant RD Lindon JC 1995Anal Chem1995,67,5:2
3Insulin resistance and in- sulin secretory dysfunction as precursors of noninsulind- edependent diabetes mellitus 显示文摘Lillioja S Mott D Spraul M 1993N Eng J Med1993,329,27:1
4A high resolution ^1H magic angle spinning NMR study of high-Mr subunit of wheatglutenin显示文摘Alberti E Humpfer E Spraul M 2001Biopolymers2001,58,1:1
5750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma显示文摘NICHOLSON J K FOXALL P J SPRAUL M 1995Anal Chem1995,67,5:1
6Risk factors for retinal occlusive disease显示文摘Lang GE Spraul CE 1997Klin Monatsbl Augenheilkd1997,211,4:1
7Risk factors for retinal occlusive disease显示文摘Land GE Spraul CE 1997Klin Monatsbl Augenheilkd1997,211,4:1
8750 MHz IH and 1H-13C NMR spectroscopy of human blood plasma显示文摘Nicholson J K Foxall P J Spraul M 1995Anal Chem1995,67,5:1
9Effect of octreotide combined with growth factors on proliferation of RPE cells in vitro显示文摘Amann J Kaven C Spraul CW 2000Ophthalmologe2000,97,11:1
10Prospective randomized con- trolled studsy of Hydrofiber dressing containing ionic silver or calci- um alginate dressings in non-ischaemic diabetic foot ulcers显示文摘Jude EB Apelqvist J Spraul M 2007Dia- bet Med2007,24,3:1
11750 MHz ^1 H NMR spectroscopy characterization of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease 显示文摘Holmes E Foxall PJD Spraul M 1997J Phannaceut Biomed1997,15,11:1
12Liver diseases related to MDR3 (ABCB4) gene deficiency 显示文摘Gonzales E Davit- Spraul A Baussan C 2009Front Biosci2009,14,:1
13Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus 显示文摘Lillioja S Mott DM Spraul M 1993N Engl J Med1993,329,27:1
14Prospective randomized controlled study of Hydrofiber dressing containing ionic silver or calcium alginate dressings in non-ischaemic diabetic foot ulcers显示文摘Jude EB Apelqvist J Spraul M 0,,:1
15Ultrasound biomicroscopy in iris lesions 显示文摘Buchwald HJ Spraul CW Wagner P 1999Ophthalmology1999,96,2:1
16Vitreous hemorrhage显示文摘Spraul CW Grossniklaus HE 0,,:1
17750 MHz 1H and 1H - 13C NMR spectroscopy of human blood plasma显示文摘Nicholson JK Foxall PJ Spraul M 1995Anal Chem1995,67,:1
18Biomarkers of oxidative stress: an analytical approach 显示文摘Therond P Bonnefont Rousselot D Davit Spraul A 2000Curr Opin Clin Nutr Metab Care2000,3,5:1
19Insulin resistance and insulin secretory dysfunction as precursors of non-insulindependent diabetes mellitus:prospective studies of Pima Indians显示文摘Lillioja S Mott DM Spraul M 1993N Engl J Med1993,329,27:1
20In-the-bag dislocation of a hydrophilic acrylic intraocular lens显示文摘Hesse Y Spraul CW Bruckner KA 2003J Cataract Refract Surg2003,29,4:1
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