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| 1 | Cellular and molecular mechanisms of intestinal fibrosis显示文摘Fibrosis is a chronic and progressive process characterized by an excessive accumulation of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue. Intestinal fibrosis may develop in several different enteropathies, including inflammatory bowel disease. It develops through complex cell, extracellular matrix, cytokine and growth factor interactions. Distinct cell types are involved in intestinal fibrosis, such as resident mesenchymal cells (fibroblasts, myofibroblasts and smooth muscle cells) but also ECM-producing cells derived from epithelial and endothelial cells (through a process termed epithelialand endothelial-mesenchymal transition), stellate cells, pericytes, local or bone marrow-derived stem cells. The most important soluble factors that regulate the activation of these cells include cytokines, chemokines, growth factors, components of the renin-angiotensin system, angiogenic factors, peroxisome proliferator-activated receptors, mammalian target of rapamycin, and products of oxidative stress. It soon becomes clear that although inflammation is responsible for triggering the onset of the fibrotic proc-ess, it only plays a minor role in the progression of this condition, as fibrosis may advance in a self-perpetuating fashion. Definition of the cellular and molecular mechanisms involved in intestinal fibrosis may provide the key to developing new therapeutic approaches. | Silvia Speca Ilaria Giusti Florian Rieder Giovanni Latella | 2012 | World Journal of Gastroenterology2012，18，28： | 32 |
| 2 | A randomized,wait-list controlled clinical trial:The effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients显示文摘 | Speca M Carlson LE Goodey E | 2000 | Psychosomat Med2000，62，5： | 1 |
| 3 | Mindfulness- based stress reduction in relation to quality of life, mood,symptoms of stress, and immune parameters in breast and prostate cancer outpatients 显示文摘 | Carlson LE Speca M Patel KD | 2003 | Psychosom Med2003，65，4： | 1 |
| 4 | Effects of straw mulch on growth and yield of durum wheat during transition to conservation agriculture in mediterranean environment 显示文摘 | STAGNARI F GALIENI A SPECA S | 2014 | Field Crops Research2014，167，5： | 1 |
| 5 | One year pre - post interven don follow up of psychologcalimmune, endocrine and blood pressure outcomes of mindfulness- based stress reduction (MB- SR) in breast and prostate cancer outpatients 显示文摘 | Carlson EE Speca M Faris P | 2007 | Brain Behavior and Immunity2007，21，8： | 1 |
| 6 | Coordination complexes of the N-oxides of aromatic diimines and diazines显示文摘 | Speca A N Chasan D E | 1976 | Coord Chem Rev1976，20，： | 1 |
| 7 | Mindfulness-based stress reduction in relation to quality of life,mood,symptoms of stress,and immune parameters in breast and prostate cancer outpatients显示文摘 | Carlson LE Speca M Patel KD | 2003 | Psychosom Med2003，65，4： | 1 |
| 8 | One year pre-post intervention follow-up of psychological,immune,endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients显示文摘 | Carlson LE Speca M Faris P | 2007 | Brain Behav Immun2007，21，8： | 1 |
| 9 | Combining an SSRI with an anticon-vulsant in depressed patients with dysphoric mood:an open study显示文摘 | Pasquini M Picardi A Speca A | | 0，，： | 1 |
| 10 | Ovarian factor infertility显示文摘 | Summaria V Speca S Mirk P | 1998 | Rays1998，23，： | 1 |
| 11 | Ovarian factor infertility 显示文摘 | SummariaV Speca S Mirk P | 1998 | Rays1998，23，4： | 1 |
| 12 | Ovarianfactorinfertility 显示文摘 | Summaria V Speca S MirkP | 1998 | Rays1998，23，4： | 1 |
| 13 | A randomized,wait-list controlled clinical trial:the effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients显示文摘 | Carlson LE Goodey E | 2000 | Sychosom Med2000，62，5： | 1 |
| 14 | Can we prevent, reduce or reverse intestinal fibrosis in IBD? 显示文摘 | LATELLA G SFERRA R SPECA S | 2013 | Eur Rev Med Pharmacol Sci2013，17，10： | 1 |
| 15 | Ovarian factor infertility 显示文摘 | Sum maria V Speca S Mirk P | 1998 | Rays1998，23，4： | 1 |
| 16 | Ovarian factor infertility显示文摘 | Summaria V Speca S Mirk P | 1998 | Rays1998，23，4： | 1 |
| 17 | Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cel s in vitro显示文摘 | Festuccia C Muzi P Gravina GL Millimaggi D Speca S Dolo V | 2007 | Int J Oncol2007，30，1： | 1 |
| 18 | Results of the 4th scientific workshop of the ECCO (I): Pathophysiology of intestinal fibrosis in IBD显示文摘 | Giovanni Latella Gerhard Rogler Giorgos Bamias Christine Breynaert Jon Florholmen Gianluca Pellino Shimon Reif Silvia Speca Ian C. Lawrance | 2014 | Journal of Crohn’s and Colitis2014，，： | 1 |
| 19 | Mindfulness-based stress reduc- tion in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients 显示文摘 | Carlson LE Speca M Pate1 KD | 2003 | Psychosom Med2003，65，4： | 1 |
| 20 | Mindfulness-based stress reduction in relation to quality of life,mood,symptoms of stress,and immune parameters in breast and prostate cancer outpatients显示文摘 | Carlson LE Speca M Patel KD | 2003 | Psychosom Med2003，65，4： | 1 |
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